prostaglandin G2

Three steps

• CHEBI:16857Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC7A5extracellular space, cytosolOne of 4 routes

• (R)-lactaldehydeReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

  Catalysed by SLCO2A1, GLO1, GLOD4, ADH1C and 6 moreextracellular space, cytosol

• L-isoleucineReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC7A5extracellular space, cytosolOne of 4 routes

• CHEBI:17203Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC7A5extracellular space, cytosolOne of 3 routes

• dehydroascorbic acidReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DBHextracellular space, cytosolOne of 19 routes

• estroneReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. Estrone 3-sulfate sulfohydrolase

  Catalysed by SLCO1B1, STSextracellular space, cytosolOne of 3 routes

• propanoateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• 5'-deoxyadenosineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 moreOne of 4 routes

• sulfiteReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. Sulfide:glutathione,quinone oxidoreductase
  3. Persulfide dioxygenase

  Catalysed by SLCO2A1, SQOR, ETHE1extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Lecithin Retinol Acyltransferase

  Catalysed by PTGS1, PTGS2, RETSAT, LRATcytosol

• all-trans-retinyl hexadecanoateReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA

  Catalysed by PTGS1, PTGS2, RETSAT, DGAT1 and 4 moreOne of 2 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. aryl sulfotransferase (PAPS)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 2 moreextracellular space, cytosol

• 3,3',5'-triiodo-L-thyronine sulfateReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodo-L-thyronine sulfate + iodide + A + H(+) = L-thyroxine sulfate + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• 3,3'-diiodo-L-thyronineReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 2 moreextracellular space, cytosolOne of 5 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine sulfate + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 moreOne of 2 routes

• N-acetylserotoninReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. acetyl-CoA:aralkylamine N-acetyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AANATextracellular space, cytosol

• CHEBI:17724Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. Formation of Homocystine
  3. Trimethylaminoacetate:L-homosysteine S-methyltransferase

  Catalysed by SLCO2A1, BHMT, BHMT2extracellular space, cytosolOne of 2 routes

• glycine betaineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. choline + A = betaine aldehyde + AH2
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by PTGS1, PTGS2, CHDH, ALDH7A1cytosolOne of 4 routes

• urateReach from here →
  1. prostaglandin-endoperoxide synthase (prostaglandin G2)
  2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
  3. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)

  Catalysed by PTGS1, PTGS2, SLCO2A1, SLC22A12 and 1 moreendoplasmic reticulum, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-hydroxy-L-tryptophanReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. 5-hydroxy-L-tryptophan + H(+) = serotonin + CO2

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DDCextracellular space, cytosol

• prostaglandin F1Reach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of prostaglandin E1 (cytosol to extracellular)
  3. prostaglandin E1 + NADPH + H(+) = prostaglandin F1 + NADP(+)

  Catalysed by SLCO1B1, DHRS1extracellular space, cytosol

• CHEBI:17895Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC7A5extracellular space, cytosolOne of 4 routes

• all-trans-retinalReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol: NADP+ oxidoreductase

  Catalysed by PTGS1, PTGS2, RETSAT, DHRS3 and 5 morecytosolOne of 6 routes

• butanoateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of estrone 3-sulfate (cytosol to extracellular)
  3. butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

  Catalysed by SLCO1B1, SLC22A9extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:18019Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC7A6extracellular space, cytosolOne of 2 routes

• a diacylglycerolReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol

  Catalysed by PTGS1, PTGS2, RETSAT, PNPLA4 and 1 more

• L-glutamineReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by SLCO2A1, SLC3A2, SLC7A5, SLC7A10extracellular space, cytosolOne of 4 routes

• (R)-3,4-dihydroxymandelaldehydeReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. (R)-noradrenaline + O2 + H2O = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, MAOA and 1 moreextracellular space, cytosol

• CHEBI:18183Reach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)
  3. gamma-glutamylcyclotransferase ((5-L-glutamyl)-L-amino acid)

  Catalysed by SLCO2A1, GGT1, GGT5, GGTLC2 and 5 moreextracellular space, cytosol

• (R)-normetanephrineReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:catechol O-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, COMT and 1 moreextracellular space, cytosol

• 3',5'-diiodo-L-thyronineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. (R)-malate + A = oxaloacetate + AH2
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by PTGS1, PTGS2, D2HGDH, AGXT2

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. formaldehyde to 5,10-methylene-THF conversion

  Catalysed by PTGS1, PTGS2, KDM1A, KDM1Bcytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. Formation of Homocystine
  3. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase

  Catalysed by SLCO2A1, MTRextracellular space, cytosolOne of 4 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of GSH and prostaglandin G2 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLCO2A1, CARS2extracellular space, cytosol

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A6 and 3 moreextracellular space, cytosol

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by SLCO1B1, UGT2B7, UGT1A1, UGT1A4extracellular space, cytosol

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A1 and 1 moreextracellular space, cytosol

• (S)-lactoyl-AMPReach from here →
  1. prostaglandin-endoperoxide synthase (prostaglandin G2)
  2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

  Catalysed by PTGS1, PTGS2, SLCO2A1, AARS1 and 1 moreendoplasmic reticulum, inner side of the membrane, outer side of the membrane

• (S)-lactoyl-CoAReach from here →
  1. prostaglandin-endoperoxide synthase (prostaglandin G2)
  2. prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)
  3. (S)-lactate + ATP + CoA = (S)-lactoyl-CoA + AMP + diphosphate

  Catalysed by PTGS1, PTGS2, SLCO2A1, ACSS2endoplasmic reticulum, inner side of the membrane, outer side of the membrane

• 3-iodothyronamineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 2 moreOne of 2 routes

• 3-iodo-L-thyronineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 2 moreOne of 2 routes

• 3'-iodo-L-thyronineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 2 moreOne of 2 routes

• serotonin O-sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. transport of prostaglandin G2 (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3extracellular space, cytosolOne of 2 routes

• L-thyronineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• thyronamineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 1 more

• 3'-iodothyronamineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 2 moreOne of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. prostaglandin G2 + AH2 = prostaglandin H2 + A + H2O
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by PTGS1, PTGS2, AIFM1, PYROXD1 and 2 moreOne of 2 routes