chenodeoxycholoyl-CoA

Three steps

• arsenic triglutathioneReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by BAAT, ABCC4, AS3MTinner side of the membrane, outer side of the membraneOne of 3 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by BAAT, ABCC4, MGST3inner side of the membrane, outer side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX1, GPX4inner side of the membrane, outer side of the membrane

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, GPX4inner side of the membrane, outer side of the membrane

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by BAAT, ABCC4, GSTP1inner side of the membrane, outer side of the membrane

• deoxycholateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. chenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = cholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. cytochrome P450 (cholate)

  Catalysed by ACOT8, BAAT, CYP8B1, CYP7A1cytosolOne of 2 routes

• a quinolReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by BAAT, ABCC4, SQORinner side of the membrane, outer side of the membrane

• 5(S)-HETEReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 9 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of LTD4 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• L-ascorbic acidReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by BAAT, ABCC4, CLIC1, GSTO1 and 1 moreinner side of the membrane, outer side of the membrane

• glycocholateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. solute carrier organic anion transporter (glycocholate)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes

• hydrogen sulfideReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by BAAT, ABCC4, TSTD1inner side of the membrane, outer side of the membrane

• an alcoholReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, CP, PRDX6inner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of arachidonate (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• serotoninReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of serotonin (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• taurocholateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 5 routes

• glycochenodeoxycholic acidReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. chenodeoxycholate:CoA ligase (AMP-forming)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by ACOT8, BAAT, SLC27A5cytosol, peroxisomeOne of 2 routes

• glycolithocholic acidReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• D-glucoseReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + a di-trans,poly-cis-dolichyl phosphate + H(+)
  3. beta-D-glucosyl-(1->3)-O-chenodeoxycholate + H2O = chenodeoxycholate + D-glucose

  Catalysed by ACOT8, BAAT, GBA2

• tert-butanolReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

  Catalysed by BAAT, ABCC4, CLIC2, GPX1 and 3 moreinner side of the membrane, outer side of the membrane

• gamma-Glu-AlaReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. gamma-glutamyltransferase (alanine)

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 6 moreextracellular space, cytosol

• 3,3',5-triiodo-L-thyronineReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• choloyl-CoAReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. chenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = cholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
  3. cholate + ATP + CoA = choloyl-CoA + AMP + diphosphate

  Catalysed by ACOT8, BAAT, CYP8B1, SLC27A5

• prostaglandin E1Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. Glutathione: 15-HPETE oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 9 moreextracellular space, cytosolOne of 2 routes

• leukotriene A4Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of leukotriene A4 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 4 routes

• (R)-S-lactoylglutathioneReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 2 moreextracellular space, cytosolOne of 3 routes

• S-formylglutathioneReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. alcohol dehydrogenase (formaldehyde)

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 6 moreextracellular space, cytosolOne of 2 routes

• dehydroepiandrosterone 3-sulfateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 2 routes

• leukotriene C4Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of leukotriene C4 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 7 routes

• glutathione disulfideReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 9 moreextracellular space, cytosolOne of 35 routes

• taurolithocholate 3-sulfateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• 5-oxo-L-prolineReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. glutathione = L-cysteinylglycine + 5-oxo-L-proline

  Catalysed by BAAT, ABCC4, CHAC2, CHAC1inner side of the membrane, outer side of the membrane

• histamineReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of histamine (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-thyroxineReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• S-sulfanylglutathioneReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. Sulfide:glutathione,quinone oxidoreductase

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 1 moreextracellular space, cytosol, mitochondrial matrixOne of 5 routes

• dopamineReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of dopamine (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholate 3-sulfateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• estrone 3-sulfateReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of estrone 3-sulfate (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3 and 1 moreextracellular space, cytosolOne of 2 routes

• prostaglandin E2Reach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• L-cysteinylglycineReach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (GSH)
  3. glutathione gamma-glutamylaminopeptidase

  Catalysed by BAAT, SLCO1A2, SLC7A9, SLCO1B3 and 6 moreextracellular space, cytosolOne of 6 routes

• ubiquinol-10Reach from here →
  1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
  2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10

  Catalysed by BAAT, ABCC4, SQORinner side of the membrane, outer side of the membrane

• (R)-noradrenalineReach from here →
  1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
  2. solute carrier organic anion transporter (chenodiol)
  3. transport of noradrenaline (cytosol to extracellular)

  Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes