chenodeoxycholoyl-CoA

1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)

Catalysed by ACOT8, BAAT

1. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

Catalysed by BAAT

1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)

Catalysed by BAAT

1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
2. Chenodeoxycholic acid 6alpha-hydroxylase

Catalysed by ACOT8, BAAT, CYP3A4cytosol

1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
2. solute carrier organic anion transporter (chenodiol)

Catalysed by ACOT8, BAAT, SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

1. chenodeoxycholoyl-CoA + H2O = chenodeoxycholate + CoA + H(+)
2. chenodeoxycholate:CoA ligase (AMP-forming)
3. bile acid-CoA: amino acid N-acyltransferase

Catalysed by ACOT8, BAAT, SLC27A5cytosol, peroxisomeOne of 8 routes

1. chenodeoxycholoyl-CoA + taurine = taurochenodeoxycholate + CoA + H(+)
2. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
3. cumene hydroperoxide + 2 glutathione = 2-phenylpropan-2-ol + glutathione disulfide + H2O