(2E)-decenoyl-CoA

Three steps

• (R)-carnitineReach from here →
  1. Fatty Acid Beta Oxidation (C10:1->C8:0), Peroxisomal
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. O-octanoyl-(R)-carnitine(in) + (R)-carnitine(out) = O-octanoyl-(R)-carnitine(out) + (R)-carnitine(in)

  Catalysed by ACAA1, HSD17B4, EHHADH, CROT and 1 moreperoxisome, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• oxaloacetateReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. ATP citrate lyase (citrate)

  Catalysed by MECR, ACLYmitochondrial matrix, cytosol

• anilineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Acetyl-CoA:arylamine N-acetyltransferase

  Catalysed by MECR, NAT2, NAT1mitochondrial matrix, cytosol

• CHEBI:17312Reach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. N1,N12-diacetylspermine to N1-acetylspermine conversion

  Catalysed by MECRmitochondrial matrix, cytosolOne of 2 routes

• L-cysteineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by MECR, NAGSmitochondrial matrix, cytosol

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by MECR, HADHA, ACADVL, HADHBmitochondrial matrix, cytosol

• CHEBI:17927Reach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by MECRmitochondrial matrix, cytosol

• dodecanoateReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Lauroyl-CoA hydrolase

  Catalysed by MECR, ACOT7, BAAT, ACOT1 and 1 moremitochondrial matrix, cytosolOne of 2 routes

• (5Z)-dodecenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by MECR, HADHA, ACAA2, HADHBmitochondrial matrix, cytosolOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by MECR, HADHA, ACADVL, HADHBmitochondrial matrix, cytosolOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by MECR, HADHA, ACADVL, HADHBmitochondrial matrix, cytosol

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by MECR, ECHS1, ACAA2, HADHmitochondrial matrix, cytosolOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by MECR, ECHS1, ACAA2, HADHmitochondrial matrix, cytosolOne of 2 routes

• elaidic acidReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 5 routes

• CHEBI:28701Reach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by MECR, ACAA1, SCP2, MYO5Bmitochondrial matrix, cytosol, peroxisomeOne of 7 routes

• decanalReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. Decanoyl-CoA hydrolase
  3. decanal + NAD(+) + H2O = decanoate + NADH + 2 H(+)

  Catalysed by MECR, ACOT7, ALDH3A2mitochondrial matrix, cytosol

• taurineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by MECR, BAATmitochondrial matrix, cytosolOne of 2 routes

• glycineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by MECR, GLYAT, GLYATL2, GLYATL1mitochondrial matrix, cytosolOne of 12 routes

• (R)-methylmalonyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by MECR, ALDH6A1mitochondrial matrix, cytosolOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. (S)-methylmalonyl-CoA hydrolase

  Catalysed by MECRmitochondrial matrix, cytosol

• 3'-dephospho-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. acid phosphatase 2, lysosomal (CoA)

  Catalysed by MECR, ACP2mitochondrial matrix, cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. (2E)-dodecenoyl-CoA formation

  Catalysed by MECRmitochondrial matrix, cytosolOne of 8 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by MECR, ACAA1, MYO5Bmitochondrial matrix, cytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by MECR, ACSM4, ACSM1, ACSM2A and 3 moremitochondrial matrix, cytosolOne of 10 routes

• glutaryl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Production of Glutaryl Carnitine

  Catalysed by MECR, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Itaconate:CoA ligase (GDP-forming)

  Catalysed by MECR, SUCLG1, SUCLG2, SUCLA2mitochondrial matrix, cytosolOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 12 routes

• phytanoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. phytanate-CoA ligase

  Catalysed by MECRmitochondrial matrix, cytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 4 moremitochondrial matrix, cytosolOne of 15 routes

• sphing-4-enineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by MECR, ASAH1, ACER2, ACER1 and 1 moremitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by MECR, SAT1, SAT2mitochondrial matrix, cytosolOne of 3 routes

• L-methionineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by MECR, NAGSmitochondrial matrix, cytosol

• L-alanineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by MECRmitochondrial matrix, cytosol

• L-asparagineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by MECR, NAGSmitochondrial matrix, cytosol

• L,L-cystathionineReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by MECR, NAGSmitochondrial matrix, cytosol

• an acyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by MECR, ASAH1, ACER2, ACER1 and 1 moremitochondrial matrix, cytosol, Golgi apparatusOne of 3 routes

• (3Z)-dodecenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by MECR, HADHA, ACAA2, HADHBmitochondrial matrix, cytosolOne of 3 routes

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by MECR, SLC27A2, SLC27A5mitochondrial matrix, cytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by MECR, SLC27A2, SLC27A5mitochondrial matrix, cytosolOne of 4 routes

• monodehydro-L-ascorbate radicalReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)
  3. N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by MECR, GLYATL2, PAMmitochondrial matrixOne of 2 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. Carnitine O-Palmitoyltransferase

  Catalysed by MECR, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by MECR, SLC27A2, ACSL4, ACSL3 and 5 moremitochondrial matrix, cytosolOne of 11 routes

• (2E)-hexenoyl-CoAReach from here →
  1. Fatty Acid Beta Oxidation (C10:1->C8:0), Peroxisomal
  2. Fatty Acid Beta Oxidation (C8->C6), Peroxisomal
  3. trans-hex-2-enoyl-CoA reductase

  Catalysed by ACAA1, HSD17B4, EHHADH, ACOX1 and 1 moreperoxisome, mitochondrial matrixOne of 3 routes

• 3-oxotetradecanoyl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. dodecanoyl-CoA + malonyl-CoA + H(+) = 3-oxotetradecanoyl-CoA + CO2 + CoA

  Catalysed by MECR, ELOVL6mitochondrial matrix, cytosol

• 3-hydroxyisovaleryl-CoAReach from here →
  1. trans-dec-2-enoyl-CoA reductase
  2. fatty-acyl-CoA synthase (N-C12:0CoA)
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by MECR, CPT1A, CPT1Bmitochondrial matrix, cytosol