5-methylsulfanyl-2,3-dioxopentyl phosphate

Three steps

• 2-iminopropanoateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. 2-iminopropanoate + H2O = pyruvate + NH4(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• phosphoenolpyruvic acidReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 3 morecytosol, extracellular space

• 13-cis-retinalReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and retinoate (cytosol to extracellular)
  3. retinal dehydrogenase (13-cis-retinal)

  Catalysed by SLC16A4, SLC16A5, ALDH1A2, ALDH1A1cytosol, extracellular space, endoplasmic reticulum

• N-acetyl-beta-neuraminic acidReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• L-ornithineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of methionine and ornithine (cytosol to extracellular)

  Catalysed by TAT, SLC7A6cytosol, extracellular spaceOne of 2 routes

• N-(acetyl)-sphing-4-enineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, ASAH1cytosol, extracellular space

• taurineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of chloride and formate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by SLC26A4, SLC6A6cytosol, extracellular spaceOne of 2 routes

• a 3-acylpyruvateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. a 3-acylpyruvate + H2O = a carboxylate + pyruvate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• acetoacetyl-CoAReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of acetoacetate and formate (cytosol to extracellular)
  3. acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate

  Catalysed by SLC16A4, SLC16A5, AACScytosol, extracellular spaceOne of 2 routes

• glycineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of glycine and methionine (cytosol to extracellular)

  Catalysed by TAT, SLC7A5cytosol, extracellular spaceOne of 8 routes

• butanoyl-CoAReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of butyrate and formate (cytosol to extracellular)
  3. Butanoate:CoA ligase (AMP-forming)

  Catalysed by SLC16A4, SLC16A5, ACSM4, ACSM1 and 4 morecytosol, extracellular spaceOne of 2 routes

• (6R)-5,10-methenyltetrahydrofolateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. Formate:tetrahydrofolate ligase (ADP-forming)
  3. 5,10-Methenyltetrahydrofolate 5-hydrolase (decyclizing)

  Catalysed by MTHFD1cytosolOne of 2 routes

• N-acetyl-D-glucosamine 6-phosphateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, AMDHD2cytosol, extracellular space

• 2-oxo-3-sulfanylpropanoateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• S-formylglutathioneReach from here →
  1. Acireductone Synthase
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by ENOPH1, ADI1, ESDcytosol

• quercetinReach from here →
  1. Acireductone Synthase
  2. acireductone dioxygenase
  3. quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO

  Catalysed by ENOPH1, ADI1, PIRcytosol

• 2-methyl-3-oxopropanoateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• guanidinoacetateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of chloride and formate (cytosol to extracellular)
  3. Transport of Guanidinoacetic Acid

  Catalysed by SLC26A4cytosol, extracellular space

• L-tryptophanReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of methionine and tryptophan (cytosol to extracellular)

  Catalysed by TAT, SLC7A5cytosol, extracellular spaceOne of 6 routes

• beta-alanineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of beta-alanine and chloride (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A6, SLC6A14cytosol, extracellular spaceOne of 2 routes

• L-alanineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of alanine and methionine (cytosol to extracellular)

  Catalysed by TAT, SLC7A5cytosol, extracellular spaceOne of 27 routes

• L-asparagineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of asparagine and methionine (cytosol to extracellular)

  Catalysed by TAT, SLC7A5cytosol, extracellular spaceOne of 5 routes

• L-phenylalanineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. transport of methionine and phenylalanine (cytosol to extracellular)

  Catalysed by TAT, SLC7A5cytosol, extracellular spaceOne of 8 routes

• L-homocysteineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by TAT, BHMT2cytosol

• S-methyl-L-methionineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by TAT, BHMT2cytosol

• N-acetylputrescineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of acetate and formate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, HDAC10cytosol, extracellular space

• kynurenateReach from here →
  1. Acireductone Synthase
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)
  3. 4-methylsulfanyl-2-oxobutanoate + L-kynurenine = kynurenate + L-methionine + H2O

  Catalysed by ENOPH1, ADI1, AADATcytosol

• N(8)-acetylspermidineReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of acetate and formate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, HDAC10cytosol, extracellular space

• N-formyl-L-kynurenineReach from here →
  1. Acireductone Synthase
  2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
  3. N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)

  Catalysed by ENOPH1, ADI1, AFMIDcytosol

• (3S)-citramalyl-CoAReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (3S)-citramalyl-CoA = pyruvate + acetyl-CoA

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of acetate and formate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by SLC16A4, SLC16A5, SLC16A1, ACY3cytosol, extracellular space

• L-methionine (S)-S-oxideReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by TAT, MSRAcytosol

• L-methionine (R)-S-oxideReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. tyrosine aminotransferase (4-methylthio-2-oxobutanoic acid)
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by TAT, MSRB3, MSRB1, MSRB2cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• 4-aminobutanoateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of chloride and formate (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC26A4, SLC6A12cytosol, extracellular spaceOne of 4 routes

• (4R)-4-hydroxy-2-oxoglutarateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (4R)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• (4S)-4-hydroxy-2-oxoglutarateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (4S)-4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 2 morecytosol, extracellular space

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. 2, 3-Diketo-5-Methylthio-1-Phosphopentane Degradation Reaction
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by SLC16A4, SLC16A5, SLC16A7, SLC16A8 and 4 morecytosol, extracellular space, mitochondrial matrix