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quercetin

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

10 compounds within 3 steps: 2 in 1, 1 in 2, 7 in 3

Does it reach a compound?

One step

COReach from here →
1. quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
Catalysed by PIR
2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoateReach from here →
1. quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
Catalysed by PIR

Two steps

1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-oneReach from here →
1. quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
2. 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
Catalysed by PIR, ADI1

Three steps

3-(methylthio)propionic acidReach from here →
Catalysed by PIR, ADI1cytosol
formateReach from here →
Catalysed by PIR

One of 2 routes

4-methylsulfanyl-2-oxobutanoateReach from here →

quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)

Catalysed by PIR, ADI1

formic acidReach from here →

quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
acireductone dioxygenase

Catalysed by PIR, ADI1cytosolOne of 2 routes

4-methylthio-2-oxobutanoic acidReach from here →

quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
Acireductone Dixoygenase 1

Catalysed by PIR, ADI1cytosol

3-(methylsulfanyl)propanoateReach from here →

quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)

Catalysed by PIR, ADI1

5-methylsulfanyl-2,3-dioxopentyl phosphateReach from here →

quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO
1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)
5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate

Catalysed by PIR, ADI1, ENOPH1