5-amino-2-oxopentanoate

Three steps

• prostaglandin A2Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by AGXT2, LDHB, LDHAL6Bmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin J2Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin J2, Lactate Antiport

  Catalysed by AGXT2, LDHB, LDHAL6Bmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

  Catalysed by AGXT2, LDHB, LDHAL6Bmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• epsilon-(gamma-L-glutamyl)-L-lysineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-ornithine(out) + L-lysine(in) = L-ornithine(in) + L-lysine(out)
  3. epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

  Catalysed by AGXT2, SLC25A2, SLC25A15, GGACTinner side of the membrane, outer side of the membrane

• N-(9Z-octadecenoyl)glycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL3, GLYATL2cytosolOne of 2 routes

• N-(9Z-octadecenoyl)-L-phenylalanineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. L-phenylalanine + (9Z)-octadecenoate = N-(9Z-octadecenoyl)-L-phenylalanine + H2O

  Catalysed by AGXT2, SLC7A6, PM20D1extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-phenylalanine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine + H2O

  Catalysed by AGXT2, SLC7A6, PM20D1extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of leucine and ornithine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by AGXT2, SLC7A6, PM20D1extracellular space, cytosol

• N-octadecanoylglycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL2cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL2cytosol

• all-trans-4-hydroxyretinoateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. cytochrome P450 (retinoate)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 4 moreextracellular space, cytosolOne of 3 routes

• N-acetylcadaverineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moreextracellular space, cytosol

• tetradecamideReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate
  3. N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

  Catalysed by AGXT2, PAM

• all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. glucuronosyltransferase (retinoate)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 6 moreextracellular space, cytosol, endoplasmic reticulum

• all-trans-18-hydroxyretinoateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. unspecific monooxygenase (retinoate)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 28 moreextracellular space, cytosolOne of 2 routes

• a phenyl acetateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 5 moreextracellular space, cytosol

• N(2)-(1-hydroxy-2-oxoethyl)-dGTPReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  3. N(2)-(1-hydroxy-2-oxoethyl)-dGTP + H2O = dGTP + glycolate + H(+)

  Catalysed by AGXT2, GRHPR, PARK7

• N(2)-(1-hydroxy-2-oxoethyl)-GMPReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. glycolate + NADP(+) = glyoxylate + NADPH + H(+)
  3. N(2)-(1-hydroxy-2-oxoethyl)-GMP + H2O = glycolate + GMP + H(+)

  Catalysed by AGXT2, GRHPR, PARK7

• N-hexadecanoylglycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL3cytosol

• N-dodecanoylglycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL2cytosolOne of 2 routes

• N-(9Z,12Z,15Z)-octadecatrienoylglycineReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate
  3. N-(9Z,12Z,15Z)-octadecatrienoylglycine + 2 L-ascorbate + O2 = N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by AGXT2, PAM

• N-decanoylglycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL2cytosolOne of 2 routes

• N-octanoylglycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL2cytosolOne of 2 routes

• octanamideReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate
  3. N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

  Catalysed by AGXT2, PAM

• (9Z,12Z,15Z)-octadecatrienamideReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate
  3. N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

  Catalysed by AGXT2, PAM

• L-homocarnosineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by AGXT2, SLC7A5, SLC7A6, CARNS1extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by AGXT2, GATM, GARTcytosol

• L-cystine-bis-glycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by AGXT2, GATM, DPEP1, DPEP2cytosol

• glycyldehydrophenylalanineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by AGXT2, GATM, DPEP1cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by AGXT2, SLC7A6, PFASextracellular space, cytosol

• kinetensinReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. Chymase

  Catalysed by AGXT2, SLC7A6, CMA1extracellular space, cytosolOne of 3 routes

• an N-(fatty acyl)-glycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL2cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by AGXT2, GATM, GLYATL2cytosol

• acetaldehydeReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by AGXT2, SLC7A6extracellular space, cytosol

• CHEBI:15345Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by AGXT2, AACSmitochondrial matrix, cytosolOne of 3 routes

• acetoneReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by AGXT2mitochondrial matrix, cytosol

• 4a-hydroxytetrahydrobiopterinReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)

  Catalysed by AGXT2, SLC7A6, TPH1, TPH2extracellular space, cytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)

  Catalysed by AGXT2, ALDH6A1mitochondrial matrixOne of 5 routes

• CHEBI:15570Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. alanine racemase

  Catalysed by AGXT2mitochondrial matrix, cytosolOne of 5 routes

• CHEBI:15611Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. L-Arginine:glycine amidinotransferase
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by AGXT2, GATM, GNMTcytosol

• 10-formyltetrahydrofolic acidReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

• (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterinReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and tryptophan (cytosol to extracellular)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by AGXT2, SLC7A6, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• trimethylenediamineReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of lysine and ornithine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by AGXT2, SLC7A5, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of histidine and ornithine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by AGXT2, SLC7A5, SLC7A6, CARNS1extracellular space, cytosol

• formateReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. glyoxylate + O2 + H2O = oxalate + H2O2 + H(+)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by AGXT2, HAO1, SLC26A6inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15765Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of ornithine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by AGXT2, SLC7A6, THextracellular space, cytosolOne of 5 routes

• malonateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by AGXT2, ME2, SLC25A10inner side of the membrane, outer side of the membraneOne of 2 routes

• alpha-D-glucosamine 6-phosphateReach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. transport of glutamine and ornithine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by AGXT2, SLC7A6, GFPT2, GFPT1extracellular space, cytosol

• homogentisateReach from here →
  1. L-ornithine + glyoxylate = 5-amino-2-oxopentanoate + glycine
  2. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine
  3. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by AGXT2, AADAT, HPDcytosolOne of 2 routes

• CHEBI:16174Reach from here →
  1. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by AGXT2, PKM, PKLR, NME4 and 5 morecytosolOne of 3 routes