an S-substituted L-cysteine

Three steps

• N(omega)-methyl-L-arginineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by KYAT1, KYAT3, AGXT2mitochondrial matrixOne of 3 routes

• 3-hydroxy-2-methylpropanoateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine
  3. 3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)

  Catalysed by KYAT1, KYAT3, AGXT2, HIBADH

• prostaglandin E3Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin E3, Lactate Antiport

  Catalysed by KYAT1, KYAT3, LDHB, LDHAL6Bmitochondrial matrix, extracellular space, cytosolOne of 4 routes

• prostaglandin A2Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by KYAT1, KYAT3, LDHB, LDHAL6Bmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• prostaglandin J2Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of Prostaglandin J2, Lactate Antiport

  Catalysed by KYAT1, KYAT3, LDHB, LDHAL6Bmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. Transport of 15-Keto-Prostaglandin F2A, Lactate Antiport

  Catalysed by KYAT1, KYAT3, LDHB, LDHAL6Bmitochondrial matrix, extracellular space, cytosolOne of 2 routes

• all-trans-4-hydroxyretinoateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. cytochrome P450 (retinoate)

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 5 moreextracellular space, cytosolOne of 3 routes

• N-acetylcadaverineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylcadaverine + H2O = cadaverine + acetate

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol

• all-trans-retinoyl-1-O-(beta-D-glucuronate)Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. glucuronosyltransferase (retinoate)

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 7 moreextracellular space, cytosol, endoplasmic reticulum

• all-trans-18-hydroxyretinoateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. unspecific monooxygenase (retinoate)

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 29 moreextracellular space, cytosolOne of 2 routes

• a phenyl acetateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. a phenyl acetate + H2O = a phenol + acetate + H(+)

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 6 moreextracellular space, cytosol

• CHEBI:15345Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by KYAT1, KYAT3, AACSmitochondrial matrix, cytosolOne of 3 routes

• acetoneReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by KYAT1, KYAT3mitochondrial matrix, cytosol

• propionyl-CoAReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)

  Catalysed by KYAT1, KYAT3, AGXT2, ALDH6A1mitochondrial matrixOne of 5 routes

• CHEBI:15570Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. alanine racemase

  Catalysed by KYAT1, KYAT3, AGXT2mitochondrial matrix, cytosol

• L-leucineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and leucine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 10 routes

• 10-formyltetrahydrofolic acidReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. Formate:tetrahydrofolate ligase (ADP-forming)

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosolOne of 2 routes

• CHEBI:15699Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and homoserine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• malonateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

  Catalysed by KYAT1, KYAT3, ME2, SLC25A10inner side of the membrane, outer side of the membraneOne of 2 routes

• CHEBI:15971Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and histidine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• methanethiolReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. L-cysteinyl-[sulfatase] + 2 a thiol + O2 = an organic disulfide + 3-oxo-L-alanyl-[sulfatase] + hydrogen sulfide + H2O + H(+)
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by KYAT1, KYAT3, SUMF1, SELENBP1

• CHEBI:16174Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. pyruvate kinase (dTDP)
  3. nucleoside-diphosphate kinase (dADP)

  Catalysed by KYAT1, KYAT3, PKM, PKLR and 6 morecytosolOne of 3 routes

• sulfateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. transport of malate and sulfate (cytosol to mitochondria)

  Catalysed by KYAT1, KYAT3, ME2, SLC25A10mitochondrial matrix, cytosolOne of 5 routes

• L-cystineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A9 and 1 moremitochondrial matrix, extracellular space, cytosol

• CHEBI:16284Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. pyruvate kinase (dTDP)
  3. deoxythymidylate kinase (dADP)

  Catalysed by KYAT1, KYAT3, PKM, PKLR and 1 morecytosol, mitochondrial matrixOne of 3 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by KYAT1, KYAT3, AGXT2, ABATmitochondrial matrixOne of 3 routes

• L-citrullineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 4 routes

• L-valineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and valine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 9 routes

• L-arginineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A6mitochondrial matrix, extracellular space, cytosolOne of 8 routes

• CHEBI:16497Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by KYAT1, KYAT3, PKM, PKLRcytosol

• protein polypeptide chainReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. PROTEIN_BS

  Catalysed by KYAT1, KYAT3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol

• CHEBI:16633Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by KYAT1, KYAT3, AGXT2, SCLYmitochondrial matrix, cytosol

• Met-tRNA(Met)Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by KYAT1, KYAT3, TYW1B, TYW1 and 1 morecytosol

• (R)-glycerateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by KYAT1, KYAT3, AGXT, GRHPRcytosolOne of 4 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by KYAT1, KYAT3, TYW1B, TYW1 and 1 more

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by KYAT1, KYAT3, LDHA, LDHB and 4 more

• CHEBI:16857Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 7 routes

• ferrocytochrome cReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. (S)-Lactate:ferricytochrome-c 2-oxidoreductase

  Catalysed by KYAT1, KYAT3, LDHB, LDHAL6B and 1 moremitochondrial matrix, cytosolOne of 2 routes

• glycolaldehydeReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by KYAT1, KYAT3, AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by KYAT1, KYAT3, NPLcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• CHEBI:17203Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 6 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 4 moreextracellular space, cytosol, endoplasmic reticulum

• sulfiteReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. transport of malate and sulfite (cytosol to mitochondria)

  Catalysed by KYAT1, KYAT3, ME2, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

• enol-oxaloacetateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by KYAT1, KYAT3, ME2, SDHB and 1 more

• AH2Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by KYAT1, KYAT3, AGXT2, MOCOSmitochondrial matrixOne of 7 routes

• L-cysteineReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by KYAT1, KYAT3, AGXT2, SLC7A5mitochondrial matrix, extracellular space, cytosolOne of 22 routes

• Ala-tRNA(Ala)Reach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by KYAT1, KYAT3, AGXT2, AARS1mitochondrial matrix, cytosol

• 4-methylumbelliferyl acetateReach from here →
  1. an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by KYAT1, KYAT3, SLC16A4, SLC16A5 and 6 moreextracellular space, cytosol