dehydroepiandrosterone 3-sulfate

Three steps

• 3-carboxy-4-methyl-5-propyl-2-furanpropanoateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(out) + a dicarboxylate(in) = 3-carboxy-4-methyl-5-propyl-2-furanpropanoate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-sepiapterinReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
  2. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by SLC22A9, ACSM1, ACSM2A, ACSM3 and 4 moreinner side of the membrane, outer side of the membrane

• O-butanoyl-(R)-carnitineReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by SLC22A24, SLC22A8, CRATinner side of the membrane, outer side of the membraneOne of 2 routes

• O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = O-[(5Z),(8Z),(11Z),(14Z)-eicosatetraenoyl]-beta-D-glucuronate + UDP

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A6 and 3 moreextracellular space, cytosol

• 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5
  3. 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP-alpha-D-glucuronate = 20-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate + UDP + H(+)

  Catalysed by SLCO1B1, UGT2B7, UGT1A1, UGT1A4extracellular space, cytosol

• 15-O-(beta-D-glucuronosyl)-prostaglandin B1Reach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of prostaglandin B1 (cytosol to extracellular)
  3. prostaglandin B1 + UDP-alpha-D-glucuronate = 15-O-(beta-D-glucuronosyl)-prostaglandin B1 + UDP + H(+)

  Catalysed by SLCO1B1, UGT1A9, UGT2B7, UGT1A1 and 1 moreextracellular space, cytosol

• serotonin O-sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. serotonin + 3'-phosphoadenylyl sulfate = serotonin O-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 1 moreextracellular space, cytosol

• (R)-noradrenaline 4'-O-sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. sulfotransferase (noradrenaline)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3extracellular space, cytosolOne of 2 routes

• ursodeoxycholate 3-sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. ursodeoxycholate + 3'-phosphoadenylyl sulfate = ursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• tauroursodeoxycholate 3-sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. tauroursodeoxycholate + 3'-phosphoadenylyl sulfate = tauroursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of glycoursodeoxycholate (cytosol to extracellular)
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• chenodeoxycholate 3-sulfateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate + 3'-phosphoadenylyl sulfate = chenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. cytochrome P450 (cholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, CYP7A1extracellular space, cytosolOne of 4 routes

• CHEBI:240943Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by STS, SLC26A6, SLC6A5cytosol, extracellular spaceOne of 2 routes

• a quinolReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by STS, SLC25A10, SDHB, SDHAcytosol, mitochondrial matrix

• hypochlorous acidReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Peroxidase

  Catalysed by STS, SLC26A6, LPOcytosol, extracellular spaceOne of 4 routes

• potassium atomReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by STS, SLC26A6, SLC12A2, SLC12A1cytosol, extracellular spaceOne of 4 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamineReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. fatty acylamide amidohydrolase

  Catalysed by SLCO1B1, FAAHextracellular space, cytosol

• imidazole-4-acetaldehydeReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of histamine (cytosol to extracellular)
  3. amine oxidase copper containing (histamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AOC2 and 2 moreextracellular space, cytosolOne of 2 routes

• 19-hydroxyandrost-4-ene-3,17-dioneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
  3. 19-hydroxyandrostenedione,NADPH-hemoprotein reductase:oxygen 19-oxidoreductase

  Catalysed by STS, HSD3B1, HSD3B2, CYP19A1cytosol, endoplasmic reticulumOne of 2 routes

• 16alpha-hydroxyandrost-4-ene-3,17-dioneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
  3. androst-4-ene-3,17-dione + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyandrost-4-ene-3,17-dione + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by STS, HSD3B1, HSD3B2, CYP17A1cytosol, endoplasmic reticulum

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450

  Catalysed by STS, CYP17A1, CYP21A2cytosol, endoplasmic reticulum

• 11beta-hydroxyandrost-4-ene-3,17-dioneReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
  3. androst-4-ene-3,17-dione + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 11beta-hydroxyandrost-4-ene-3,17-dione + 2 oxidized [adrenodoxin] + H2O

  Catalysed by STS, HSD3B1, HSD3B2, CYP11B1cytosol, endoplasmic reticulum

• 3,4-dihydroxyphenylacetaldehydeReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. monoamine oxidase (dopamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, AOC2 and 4 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28701Reach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. chenodeoxycholate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A5extracellular space, cytosolOne of 3 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by SLC22A24, SLC22A8, CPT2, CRATinner side of the membrane, outer side of the membrane

• CHEBI:28918Reach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of noradrenaline (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:phenylethanolamine N-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, PNMTextracellular space, cytosol

• K(+)Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by STS, SLC25A14, SLC25A30, SLC1A7 and 4 morecytosol, inner side of the membrane, outer side of the membraneOne of 5 routes

• Asp-tRNA(Asp)Reach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. L-Aspartate:tRNA(Asp) ligase (AMP-forming)

  Catalysed by STS, SLC25A14, SLC25A30, DARS1cytosol, inner side of the membrane, outer side of the membrane

• hydrogen sulfideReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
  3. 3alpha-hydroxysteroid 3-dehydrogenase (Si-specific) (H2S2O3)

  Catalysed by STS, SLC25A14, SLC25A30, SLC26A1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• acetateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by STS, CYP17A1cytosol, endoplasmic reticulumOne of 7 routes

• formic acidReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. 3beta-Hydroxyandrost-5-en-17-one:NAD+ 3-oxidoreductase/delta5-delta-4 isomerase
  3. cytochrome P450 (4-androstene-3,17-dione)

  Catalysed by STS, HSD3B1, HSD3B2, CYP19A1cytosol, endoplasmic reticulumOne of 3 routes

• citric acidReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Citrate Transport, Mitochondrial

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 10 routes

• butyric acidReach from here →
  1. dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)
  2. butanoate + ATP + CoA = butanoyl-CoA + AMP + diphosphate
  3. Butyryl-CoA hydrolase

  Catalysed by SLC22A9, ACSM1, ACSM2A, ACSM3 and 3 moreinner side of the membrane, outer side of the membrane, cytosol

• (indol-3-yl)acetateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• isocitric acidReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 6 routes

• nicotinateReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. urate(in) + glutarate(out) = urate(out) + glutarate(in)
  3. nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

  Catalysed by SLC22A24, SLC22A8, SLC22A12, SLC22A13inner side of the membrane, outer side of the membrane

• cis-aconitic acidReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2

  Catalysed by STS, SLC25A10, SLC25A1cytosol, mitochondrial matrixOne of 6 routes

• N-carbamoyl-L-aspartateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)

  Catalysed by STS, SLC25A14, SLC25A30, CADcytosol, inner side of the membrane, outer side of the membrane

• a phenolReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. an aryl sulfate + H2O = a phenol + sulfate + H(+)
  3. an aryl sulfate + H2O = a phenol + sulfate + H(+)

  Catalysed by STS, ARSL, ARSF, ARSK and 3 morecytosol

• fatty acidReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 4 routes

• glyoxylateReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of malate and sulfate (cytosol to mitochondria)
  3. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

  Catalysed by STS, SLC25A10, CLYBLcytosol, mitochondrial matrix

• CHEBI:37946Reach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of dopamine (cytosol to extracellular)
  3. aryl sulfotransferase (dopamine)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SULT1A3 and 3 moreextracellular space, cytosol

• (S)-lactic acidReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of prostaglandin A2 (cytosol to extracellular)
  3. Transport of Prostaglandin A2, Lactate Antiport

  Catalysed by SLCO1B1extracellular space, cytosolOne of 5 routes

• L-erythro-7,8-dihydrobiopterinReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
  3. L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

  Catalysed by STS, SLC25A35, SLC25A34, SLC22A6 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-3-hydroxy-3-methylglutaryl-CoAReach from here →
  1. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  2. glutarate + succinyl-CoA = glutaryl-CoA + succinate
  3. 3-hydroxy-3-methylglutarate + glutaryl-CoA = (3S)-3-hydroxy-3-methylglutaryl-CoA + glutarate

  Catalysed by SLC22A24, SLC22A8, SUGCTinner side of the membrane, outer side of the membraneOne of 3 routes

• N-methylserotoninReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:amine N-methyltransferase

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, INMTextracellular space, cytosol

• (5-hydroxyindol-3-yl)acetaldehydeReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. Transport of 5-Hydroxyindoleacetate
  3. (5-hydroxyindol-3-yl)acetaldehyde + NAD(+) + H2O = (5-hydroxyindol-3-yl)acetate + NADH + 2 H(+)

  Catalysed by STS, SLC4A1, ALDH9A1cytosol, extracellular spaceOne of 3 routes

• taurineReach from here →
  1. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3

  Catalysed by STS, SLC26A6, SLC6A6cytosol, extracellular spaceOne of 2 routes