L-methionine

Three steps

• D-isoleucineReach from here →
  1. transport of alanine and methionine (cytosol to extracellular)
  2. D-serine(out) + L-alanine(in) = D-serine(in) + L-alanine(out)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by SLC7A5, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by SLC7A5, GSS, MGST3extracellular space, cytosol

• Xaa-L-Pro dipeptideReach from here →
  1. transport of alanine and methionine (cytosol to extracellular)
  2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)
  3. Xaa-L-Pro dipeptide + H2O = an L-alpha-amino acid + L-proline

  Catalysed by SLC7A5, SLC1A4, PEPDextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• 11-cis-retinyl esterReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Palmitoyl-CoA:retinol O-acyltransferase
  3. 11-cis-retinol + a fatty acyl-CoA = 11-cis-retinyl ester + CoA

  Catalysed by NAGS, DGAT1, LRAT, AWAT1 and 2 moremitochondrial matrix, cytosol

• (6R)-10-formyltetrahydrofolateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by SLC7A5, SHMT1, SHMT2, MTHFD1 and 1 moreextracellular space, cytosol

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC7A5, GSS, GPX1, GPX4extracellular space, cytosol

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC7A5, GSS, GPX1, GPX4extracellular space, cytosol

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by SLC7A5, GSS, GPX1, GPX4extracellular space, cytosol

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by SLC7A5, GSS, GPX1, GPX4extracellular space, cytosol

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by SLC7A5, GSS, GPX4extracellular space, cytosol

• biocytinReach from here →
  1. transport of leucine and methionine (cytosol to extracellular)
  2. L-lysine(in) + L-leucine(out) + Na(+)(out) = L-lysine(out) + L-leucine(in) + Na(+)(in)
  3. biocytin + H2O = biotin + L-lysine

  Catalysed by SLC3A2, SLC7A5, SLC7A7, BTDextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• glycodeoxycholate 3-sulfateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. Glycodeoxycholate amidohydrolase
  3. glycodeoxycholate + 3'-phosphoadenylyl sulfate = glycodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC7A5, SULT2A1extracellular space, cytosol

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. ATP citrate lyase (citrate)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by NAGS, ACLY, AGXT2mitochondrial matrix, cytosolOne of 10 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC7A5, AADAT, AGXT2extracellular space, cytosolOne of 4 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. glycine + 2-oxoglutarate = glyoxylate + L-glutamate
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC7A5, AADAT, AGXT2extracellular space, cytosolOne of 4 routes

• 1-butanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Butanoate:CoA ligase (AMP-forming)
  3. 2-(9Z-octadecenoyl)-glycerol + butanoyl-CoA = 1-butanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by NAGS, ACSM4, ACSM1, ACSM2A and 5 moremitochondrial matrix, cytosol

• 1-octanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. 2-(9Z-octadecenoyl)-glycerol + octanoyl-CoA = 1-octanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by NAGS, CROT, MOGAT2, MOGAT1mitochondrial matrix

• 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)
  3. eicosanoyl-CoA + 2-(9Z-octadecenoyl)-glycerol = 1-eicosanoyl-2-(9Z-octadecenoyl)-glycerol + CoA

  Catalysed by NAGS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosol

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. L-Methionine:tRNAMet ligase (AMP-forming)
  2. 10-Formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by MARS1, MTFMT, SHMT1cytosolOne of 7 routes

• O-butanoyl-(R)-carnitineReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Butanoate:CoA ligase (AMP-forming)
  3. butanoyl-CoA + (R)-carnitine = O-butanoyl-(R)-carnitine + CoA

  Catalysed by NAGS, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosol

• 3-oxo-(9Z)-eicosenoyl-CoAReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)
  3. very-long-chain 3-oxoacyl-CoA synthase ((7Z)-octadecenoyl-CoA)

  Catalysed by NAGS, CPT1A, CPT1C, CPT1B and 7 moremitochondrial matrix, cytosol

• (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoAReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)
  3. (6Z,9Z,12Z)-octadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,6Z,9Z,12Z)-octadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by NAGS, SLC27A2, ACSL4, ACSL3 and 8 moremitochondrial matrix, cytosolOne of 2 routes

• (2E,7Z,10Z)-hexadecatrienoyl-CoAReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial
  3. (7Z,10Z)-hexadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z)-hexadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by NAGS, HADHA, ACADVL, HADHB and 2 moremitochondrial matrix

• (2E,4Z,7Z,10Z,13Z)-hexadecapentaenoyl-CoAReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial
  3. Fatty Acid Beta Oxidation (C16:4->C16:5), Mitochondrial

  Catalysed by NAGS, HADHA, ACADVL, HADHBmitochondrial matrixOne of 4 routes

• (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial
  3. (7Z,10Z,13Z)-hexadecatrienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z,10Z,13Z)-hexadecatetraenoyl-CoA + reduced [electron-transfer flavoprotein]

  Catalysed by NAGS, HADHA, ACADVL, HADHB and 2 moremitochondrial matrix

• (2E,4Z,7Z)-decatrienoyl-CoAReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial
  3. Fatty Acid Beta Oxidation (C10:2->C10:3), Mitochondrial

  Catalysed by NAGS, ECHS1, ACAA2, HADH and 1 moremitochondrial matrixOne of 3 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by SLC7A5, GSS, GSTP1extracellular space, cytosol

• glycoursodeoxycholate 3-sulfateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. glycine to glycoursodeoxycholate conversion
  3. glycoursodeoxycholate + 3'-phosphoadenylyl sulfate = glycoursodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC7A5, SULT2A1extracellular space, cytosol

• glycochenodeoxycholate 3-sulfateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)
  3. glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by SLC7A5, BAAT, SULT2A1extracellular space, cytosol

• deoxycholateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. Glycodeoxycholate amidohydrolase
  3. Glycodeoxycholate amidohydrolase

  Catalysed by SLC7A5extracellular space, cytosol

• docosanoateReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. long-chain-fatty-acid-CoA ligase (behenic acid)
  3. Docosanoyl-CoA hydrolase

  Catalysed by NAGS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 4 routes

• a quinolReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by SLC7A5, GSS, SQORextracellular space, cytosolOne of 4 routes

• octadecanoateReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. long-chain-fatty-acid-CoA ligase (stearate)
  3. Stearoyl-CoA hydrolase

  Catalysed by NAGS, SLC27A2, ACSL4, ACSL3 and 9 moremitochondrial matrix, cytosolOne of 4 routes

• octanoateReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
  3. Octanoyl-CoA hydrolase

  Catalysed by NAGS, CROT, ACOT7mitochondrial matrix, cytosolOne of 2 routes

• imidazole-4-acetaldehydeReach from here →
  1. transport of histidine and methionine (cytosol to extracellular)
  2. L-histidine carboxy-lyase (histamine-forming)
  3. amine oxidase copper containing (histamine)

  Catalysed by SLC7A6, HDC, AOC2, AOC1 and 1 moreextracellular space, cytosolOne of 2 routes

• alpha-linolenic acidReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. Carnitine O-Palmitoyltransferase
  3. Utilized Transport

  Catalysed by NAGS, CPT1A, CPT1C, CPT1Bmitochondrial matrix, cytosol, endoplasmic reticulumOne of 2 routes

• folic acidReach from here →
  1. transport of chloride and methionine (cytosol to extracellular)
  2. transport of chloride and sulfate (cytosol to extracellular)
  3. Folate Transport by Oats

  Catalysed by SLC6A14, SLC26A6, SLC22A8, SLC22A7extracellular space, cytosolOne of 2 routes

• selenomethionineReach from here →
  1. transport of methionine and threonine (cytosol to extracellular)
  2. L-threonine ammonia-lyase (2-oxobutanoate-forming)
  3. Selenomethionine methanethiol-lyase (deaminating)

  Catalysed by SLC7A5, SDS, SDSL, CTHextracellular space, cytosol

• decanoateReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. Decanoyl-CoA hydrolase

  Catalysed by NAGS, ACSM4, ACSM1, ACSM2A and 4 moremitochondrial matrix, cytosolOne of 2 routes

• CHEBI:27760Reach from here →
  1. transport of alanine and methionine (cytosol to extracellular)
  2. L-selenocysteine selenide-lyase (L-alanine-forming)
  3. Selenocystathionine Lysteine-lyase (deaminating)

  Catalysed by SLC7A5, SCLY, CTHextracellular space, cytosolOne of 2 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. long-chain-fatty-acid-CoA ligase (DHA)
  3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA hydrolase

  Catalysed by NAGS, SLC27A2, ACSL4, ACSL3 and 7 moremitochondrial matrix, cytosolOne of 2 routes

• 5(S)-HETEReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLC7A5, GSS, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 2 routes

• hexacosan-1-olReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)
  3. hexacosanoyl-CoA + 2 NADPH + 2 H(+) = hexacosan-1-ol + 2 NADP(+) + CoA

  Catalysed by NAGS, SLC27A2, ACSL4, ACSL3 and 6 moremitochondrial matrix, cytosol

• (2-hydroxyphenyl)acetic acidReach from here →
  1. transport of methionine and phenylalanine (cytosol to extracellular)
  2. Phenylalanine Transaminase, Mitochondrial
  3. Phenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by SLC7A5, GOT2, TAT, HPDextracellular space, cytosol, mitochondrial matrix

• 3-mercaptolactic acidReach from here →
  1. transport of cysteine and methionine (cytosol to extracellular)
  2. L-Cysteine:2-oxoglutarate aminotransferase
  3. 3-Mercaptolactate:NAD+ oxidoreductase

  Catalysed by SLC7A5, GOT2, GOT1, LDHB and 3 moreextracellular space, cytosol

• O-decanoyl-(R)-carnitineReach from here →
  1. N-acetylglutamate synthase (N-acetylmethionine)
  2. medium-chain acyl-CoA ligase (decanoic acid)
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by NAGS, ACSM4, ACSM1, ACSM2A and 5 moremitochondrial matrix, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. transport of alanine and methionine (cytosol to extracellular)
  2. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC7A5, SLC7A9, SLC3A1, CTHextracellular space, cytosol

• CHEBI:28862Reach from here →
  1. L-Methionine:tRNAMet ligase (AMP-forming)
  2. glycyl-tRNA(gly) phosphorylation
  3. 2'-deoxyguanosine 5'-diphosphate:oxidized-thioredoxin 2'-oxidoreductase

  Catalysed by MARS1, TXN, RRM1, RRM2 and 2 morecytosol

• a dicarboxylateReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. Hippurate (Benzoylglycinate) Formation
  3. N-benzoylglycine(out) + a dicarboxylate(in) = N-benzoylglycine(in) + a dicarboxylate(out)

  Catalysed by SLC7A5, SLC22A6, SLC22A8extracellular space, cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 6 routes

• L-ascorbic acidReach from here →
  1. transport of glycine and methionine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by SLC7A5, GSS, CLIC1, GSTO1 and 1 moreextracellular space, cytosol