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Proteins/UNIPROT:Q15185
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway..
Function from UniProtKB (Q15185), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
368 statements
368 statements · 8 reference databases · Subject: PTGES3 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
7 reactions
prostaglandin H2prostaglandin E2
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageLeft to rightBalancedEC 5.3.99.3cytosol
Human-GEM MAR01312CC BY 4.0Reference data
prostaglandin E1prostaglandin H1
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3cytosol
7 names
Resolves to: PTGES3
MAM02716cprostaglandin E3
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3cytosol
Human-GEM MAR02583CC BY 4.0Reference data
MAM02716nprostaglandin E3
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3nucleus
Human-GEM MAR02584CC BY 4.0Reference data
prostaglandin H1prostaglandin E1
Catalysed by PTGES3
Reaction pageReversibleBalancedEC 5.3.99.3nucleus
Human-GEM MAR03985CC BY 4.0Reference data
prostaglandin E2prostaglandin H2
Catalysed by PTGES3 or PTGES2 or PTGES
Reaction pageReversibleBalancedEC 5.3.99.3endoplasmic reticulum
Human-GEM MAR08560CC BY 4.0Reference data
prostaglandin H2prostaglandin E2
Catalysed by PTGES or PTGES3 or PTGES2
Reaction pageLeft to rightBalanced
Rhea RHEA:12893CC BY 4.0Reference data