(9Z)-octadecenoyl-CoA

Three steps

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• CHEBI:28666Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. LTD4 hydrolysis

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1cytosol

• CHEBI:28701Reach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SCD, SCD5, ACOT7, BAAT and 6 morecytosol, peroxisomeOne of 7 routes

• O-decanoyl-(R)-carnitineReach from here →
  1. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  2. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  3. decanoyl-CoA + (R)-carnitine = O-decanoyl-(R)-carnitine + CoA

  Catalysed by CPT2, CRAT

• a fatty acidReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesterol-ester plasma pool to cholesterol-ester-10,13,16,19-docosa conversion
  3. a cholesterol ester + H2O = cholesterol + a fatty acid + H(+)

  Catalysed by SOAT2, SOAT1, CES1, LIPN and 2 moreendoplasmic reticulum

• Cu(2+)Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by GLYATL3, GLYATL2, PAM, CYBRD1inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O
  3. N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by GLYATL3, GLYATL2, PAMOne of 10 routes

• Gly-tRNA(Gly)Reach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosol

• chlorine(.)Reach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. Utilized Transport
  3. Carnitine Transport by Atb0

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 5 moreendoplasmic reticulum, cytosol, extracellular spaceOne of 4 routes

• phosphocholineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. 1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-hexadecanoyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 6 moreOne of 3 routes

• glycocholateReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreperoxisomeOne of 3 routes

• tetradecanoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• a 1-O-alkyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine
  3. a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-acetyl-sn-glycero-3-phosphocholine + a 1-O-alkyl-sn-glycero-3-phosphocholine

  Catalysed by LPCAT3, MBOAT1, MBOAT2, LPCAT2 and 3 more

• glutarateReach from here →
  1. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  2. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  3. glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

  Catalysed by CPT2, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• hexacosanoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• tetracosanoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• an N-acylsphinganineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. sphingosine N-acyltransferase (sphinganine)

  Catalysed by SCD, SCD5, CERS1, CERS6 and 4 morecytosolOne of 5 routes

• eicosanoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 18 routes

• (15Z)-tetracosenoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
  3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-octadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

  Catalysed by SCD, SCD5, LPGAT1, PLA2G10 and 2 moreOne of 16 routes

• (11Z)-eicosenoateReach from here →
  1. (9Z)-octadecenoyl-CoA + H2O = (9Z)-octadecenoate + CoA + H(+)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by ACOT7, ACOT8, ACOT2, THEM4 and 4 morecytosol, extracellular spaceOne of 12 routes

• 1-O-hexadecyl-sn-glycerolReach from here →
  1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycerol + phosphocholine + H(+)

  Catalysed by LPCAT4, PLB1, SMPD2

• (24S)-hydroxycholesterolReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. Cytochrome P450, Family 46, Subfamily A, Polypeptide 1

  Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, endoplasmic reticulumOne of 3 routes

• 5-aminolevulinateReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 2 more

• glycochenodeoxycholateReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. chenodeoxycholoyl-CoA + glycine = glycochenodeoxycholate + CoA + H(+)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 more

• glycochenodeoxycholic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreperoxisomeOne of 3 routes

• cholesteryl hexadecanoateReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Beta Oxidation of Long Chain Fatty Acid
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by SCD, SCD5, ACAA1, HSD17B4 and 4 moreperoxisome, endoplasmic reticulumOne of 8 routes

• glyoxylateReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. glycine + 2-oxoglutarate = glyoxylate + L-glutamate

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moreOne of 12 routes

• a 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. Acyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O-acyltransferase

  Catalysed by SCD, SCD5, LPCAT4, LPCAT3 and 2 morecytosol

• glycolithocholic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. bile acid-CoA:amino acid N-acyltransferase (glycine)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosolOne of 2 routes

• L-2-amino-3-oxobutanoic acidReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. Acetyl-CoA:glycine C-acetyltransferase

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 moremitochondrial matrix

• cholesteryl (9Z,12Z)-octadecadienoateReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. Acyl-CoA:cholesterol O-acyltransferase

  Catalysed by SOAT2, SOAT1, CEL, LIPAlysosome, endoplasmic reticulumOne of 7 routes

• 25-hydroxycholesterolReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. Steryl-ester acylhydrolase
  3. cholesterol 25-hydroxylase (cholesterol)

  Catalysed by SOAT2, SOAT1, CEL, LIPA and 1 morelysosome, endoplasmic reticulumOne of 4 routes

• 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + acetyl-CoA = 1-O-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT4, PLB1, LPCAT2, LPCAT1

• N-octanoylsphing-4-enineReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
  3. beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

  Catalysed by SOAT2, SOAT1, CEL, CES1 and 4 more

• L-ornithineReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. L-Arginine:glycine amidinotransferase

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 1 morecytosolOne of 5 routes

• a 1,3-diacylglycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. a 1-acylglycerol + an acyl-CoA = a 1,3-diacylglycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, MOGAT1cytosol

• a 1,2-diacylglycerolReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. a 2-acylglycerol + an acyl-CoA = a 1,2-diacylglycerol + CoA

  Catalysed by SCD, SCD5, MOGAT2, MOGAT3 and 3 morecytosolOne of 2 routes

• (24R)-hydroxycholesterolReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
  3. cholesterol + reduced [NADPH--hemoprotein reductase] + O2 = (24R)-hydroxycholesterol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SOAT2, SOAT1, CEL, CES1 and 4 more

• S(8)-aminomethyldihydrolipoamideReach from here →
  1. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)
  2. (9Z)-octadecenoate + glycine = N-(9Z-octadecenoyl)glycine + H2O
  3. dihydrolipoyl dehydrogenase ([protein]-N6-(lipoyl)lysine)

  Catalysed by GLYATL3, GLYATL2, FAAH, PM20D1 and 2 moremitochondrial matrix

• taurineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. Stearoyl-CoA hydrolase
  3. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by SCD, SCD5, ACOT7, BAAT and 3 morecytosolOne of 2 routes

• N-(2-hydroxytetracosanoyl)-sphinganineReach from here →
  1. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)
  2. N-(9Z-octadecenoyl)-sphinganine + H2O = sphinganine + (9Z)-octadecenoate
  3. 2-hydroxytetracosanoyl-CoA + sphinganine = N-(2-hydroxytetracosanoyl)-sphinganine + CoA + H(+)

  Catalysed by CERS5, CERS2, ACER3, CERS3

• an N-acylsphing-4-enineReach from here →
  1. cholesterol + (9Z)-octadecenoyl-CoA = cholesteryl (9Z-octadecenoate) + CoA
  2. cholesteryl (9Z-octadecenoate) + H2O = cholesterol + (9Z)-octadecenoate + H(+)
  3. a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + an N-acylsphing-4-enine

  Catalysed by SOAT2, SOAT1, CEL, CES1 and 5 moreOne of 3 routes

• N-tetracosanoylsphinganineReach from here →
  1. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)
  2. N-(9Z-octadecenoyl)-sphinganine + H2O = sphinganine + (9Z)-octadecenoate
  3. tetracosanoyl-CoA + sphinganine = N-tetracosanoylsphinganine + CoA + H(+)

  Catalysed by CERS5, CERS2, ACER3, CERS3 and 1 more

• N-hexacosanoylsphinganineReach from here →
  1. sphinganine + (9Z)-octadecenoyl-CoA = N-(9Z-octadecenoyl)-sphinganine + CoA + H(+)
  2. N-(9Z-octadecenoyl)-sphinganine + H2O = sphinganine + (9Z)-octadecenoate
  3. hexacosanoyl-CoA + sphinganine = N-hexacosanoylsphinganine + CoA + H(+)

  Catalysed by CERS5, CERS2, ACER3, CERS3 and 1 more

• O-propanoyl-(R)-carnitineReach from here →
  1. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  2. (R)-carnitine + (9Z)-octadecenoyl-CoA = O-(9Z)-octadecenoyl-(R)-carnitine + CoA
  3. propanoyl-CoA + (R)-carnitine = O-propanoyl-(R)-carnitine + CoA

  Catalysed by CPT2, CRATOne of 3 routes

• 16-hydroxyhexadecanoateReach from here →
  1. 1-hexadecanoyl-sn-glycero-3-phosphate + (9Z)-octadecenoyl-CoA = 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + CoA
  2. 1-hexadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + H2O = 2-(9Z-octadecenoyl)-sn-glycero-3-phosphate + hexadecanoate + H(+)
  3. hexadecanoate + reduced [NADPH--hemoprotein reductase] + O2 = 16-hydroxyhexadecanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by AGPAT2, GPAT3, LCLAT1, MBOAT2 and 12 more

• 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoyl-CoA = 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-O-hexadecyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphocholine + H2O = 1-O-hexadecyl-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
  3. 1-O-hexadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPCAT4, PLB1One of 2 routes

• a 1,2-diacyl-sn-glycero-3-phospho-L-serineReach from here →
  1. octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
  2. acyl-CoA pool formation and breakdown
  3. a 1-acyl-sn-glycero-3-phospho-L-serine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CoA

  Catalysed by SCD, SCD5, LPCAT4, LPCAT3 and 1 morecytosol