3,3',5'-triiodo-L-thyronine

Three steps

• sulfateReach from here →
  1. 3,3',5'-triiodo-L-thyronine + 3'-phosphoadenylyl sulfate = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)
  2. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
  3. Steryl-Sulfatase

  Catalysed by SULT1B1, SULT1A3, SULT1A4, SULT1A1 and 2 moreGolgi apparatusOne of 4 routes

• L-cystineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. thioredoxin-disulfide reductase (NADPH) (cystine)

  Catalysed by DIO1, DIO2, MOCOS, TXNRD1 and 2 morecytosolOne of 4 routes

• 11-cis-retinolReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-Retinol 11-cis-trans-isomerase

  Catalysed by DIO1, DIO2, RETSATcytosolOne of 2 routes

• cob(II)alaminReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• L-citrullineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes

• L-valineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes

• L-arginineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of arginine and cysteine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A6extracellular space, cytosolOne of 7 routes

• nitric oxideReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 2 nitrite + AH2 + 2 H(+) = 2 nitric oxide + A + 2 H2O

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• protein polypeptide chainReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. PROTEIN_BS

  Catalysed by DIO1, DIO2, MOCOScytosol

• 3'-deoxy-3',4'-didehydro-CTPReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• (S)-2-hydroxyglutarateReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. (S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• CHEBI:16856Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. cystine to cysteine conversion

  Catalysed by DIO1, DIO2, MOCOScytosolOne of 5 routes

• CHEBI:16857Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and threonine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes

• oxalic acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride and oxalate (cytosol to extracellular)

  Catalysed by DIO1, DIO2, SLC26A4, SLC26A6extracellular space, cytosol

• L-isoleucineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and isoleucine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes

• CHEBI:17203Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and proline (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 5 routes

• 5'-deoxyadenosineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 4 routes

• 1-O-acyl-sn-glycero-3-phosphocholine(1+)Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. Lecithin Retinol Acyltransferase

  Catalysed by DIO1, DIO2, RETSAT, LRATcytosol

• all-trans-retinyl hexadecanoateReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. all-trans-retinol + hexadecanoyl-CoA = all-trans-retinyl hexadecanoate + CoA

  Catalysed by DIO1, DIO2, RETSAT, DGAT1 and 4 moreOne of 2 routes

• 3,3',5-triiodo-L-thyronine sulfateReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. thyroxine 5'-deiodinase (3,3-diiodo-L-thyronine)
  3. aryl sulfotransferase (PAPS)

  Catalysed by DIO1, DIO2, DIO3, SULT1A3 and 3 morecytosolOne of 2 routes

• L-thyroxine sulfateReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  3. L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by DIO1, DIO2, SULT1A3, SULT1A4 and 1 morecytosol

• CHEBI:17724Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. dimethylglycine dehydrogenase (formaldehyde)

  Catalysed by DIO1, DIO2, KDM1A, KDM1B and 2 morecytosol

• glycine betaineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. choline + A = betaine aldehyde + AH2
  3. p-cumic alcohol:NAD+ oxidoreductase

  Catalysed by DIO1, DIO2, CHDH, ALDH7A1cytosolOne of 7 routes

• CHEBI:17895Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and tyrosine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes

• all-trans-retinalReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. retinol: NADP+ oxidoreductase

  Catalysed by DIO1, DIO2, RETSAT, DHRS3 and 5 morecytosolOne of 6 routes

• CHEBI:18019Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and lysine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC7A6extracellular space, cytosolOne of 3 routes

• a diacylglycerolReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
  3. a triacylglycerol + all-trans-retinol = an all-trans-retinyl ester + a diacylglycerol

  Catalysed by DIO1, DIO2, RETSAT, PNPLA4 and 1 more

• L-glutamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. transport of cysteine and glutamine (cytosol to extracellular)

  Catalysed by DIO1, DIO2, MOCOS, SLC3A2 and 2 moreextracellular space, cytosolOne of 5 routes

• CHEBI:18095Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of trans-4-hydroxy-L-proline (cytosol to extracellular)

  Catalysed by DIO1, DIO2, SLC26A4, CLTRN and 1 moreextracellular space, cytosol

• N-carbamoyl-beta-alanineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Transport of 3-Ureidopropionate

  Catalysed by DIO1, DIO2, SLC26A4extracellular space, cytosolOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. (R)-malate + A = oxaloacetate + AH2
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by DIO1, DIO2, D2HGDH, AGXT2

• (6R)-5,10-methylenetetrahydrofolic acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
  3. formaldehyde to 5,10-methylene-THF conversion

  Catalysed by DIO1, DIO2, KDM1A, KDM1Bcytosol

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase

  Catalysed by DIO1, DIO2, MTO1, DHFR and 1 morecytosolOne of 3 routes

• S-disulfanyl-L-cysteineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by DIO1, DIO2, MOCOS, CARS2

• 3-iodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3-iodothyronamine + iodide + A + H(+) = 3,5-diiodothyronamine + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 2 routes

• L-thyronineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-thyronine + iodide + A + H(+) = 3-iodo-L-thyronine + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 moreOne of 2 routes

• thyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. thyronamine + iodide + A + H(+) = 3-iodothyronamine + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• 3'-iodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3'-iodothyronamine + iodide + A + H(+) = 3',5'-diiodothyronamine + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1One of 2 routes

• 3,3'-diiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1One of 2 routes

• 3',5'-diiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3',5'-diiodothyronamine + iodide + A + H(+) = 3,3',5'-triiodothyronamine + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• 3,3',5'-triiodothyronamineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. 3,3',5'-triiodothyronamine + iodide + A + H(+) = 3,3',5,5'-tetraiodothyronamine + AH2

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• CHEBI:240943Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. 2-Methylbutyrylglycine Transport, Extracellular

  Catalysed by DIO1, DIO2, SLC26A4, SLC6A5extracellular space, cytosolOne of 2 routes

• hypochlorous acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. Peroxidase

  Catalysed by DIO1, DIO2, SLC26A4, LPOextracellular space, cytosolOne of 4 routes

• potassium atomReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. transport of chloride and iodide (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by DIO1, DIO2, SLC26A4, SLC12A2 and 1 moreextracellular space, cytosolOne of 2 routes

• folic acidReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. dihydrofolate:NAD+ oxidoreductase

  Catalysed by DIO1, DIO2, MTO1, DHFR and 1 morecytosolOne of 2 routes

• N-acetyl-L-cysteineReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by DIO1, DIO2, MOCOS, NAGSmitochondrial matrix

• K(+)Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

  Catalysed by DIO1, DIO2, MOCOS, SLC1A1inner side of the membrane, outer side of the membraneOne of 2 routes

• Cys-tRNA(Cys)Reach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by DIO1, DIO2, MOCOS, CARS1cytosol

• hydrogenselenideReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. A + NADH + H(+) = AH2 + NAD(+)
  3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)

  Catalysed by DIO1, DIO2, AIFM1, PYROXD1 and 1 more

• hydrogen sulfideReach from here →
  1. 3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by DIO1, DIO2, MOCOS, CTHcytosolOne of 2 routes