serotonin

Two steps

• (7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C18:3->C16:3), Mitochondrial

  Catalysed by AANAT, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

• CHEBI:17927Reach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by AANATcytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by AANAT, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by AANAT, HADHA, ACADVL, HADHBcytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by AANAT, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by AANAT, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by AANAT, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

• CHEBI:27540Reach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by AANAT, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 6 routes

• elaidic acidReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

• 5(S)-HETEReach from here →
  1. transport of GSH and serotonin (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of LTD4 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• CHEBI:28701Reach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by AANAT, ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 7 routes

• Ca(2+)Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC6A4, SLC24A1, SLC24A5, SLC24A4 and 2 moreextracellular space, cytosolOne of 3 routes

• chlorine(.)Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)

  Catalysed by SLC6A4, SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes

• glycocholateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. solute carrier organic anion transporter (glycocholate)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• cholateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• D-aspartateReach from here →
  1. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  2. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLC6A4, SLC1A7, SLC1A3, SLC1A2 and 2 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• L-aspartateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)

  Catalysed by SLC6A4, SLC1A7, SLC1A3, SLC1A2 and 2 moreextracellular space, cytosolOne of 3 routes

• (5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• chenodeoxycholateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 2 routes

• taurocholateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. solute carrier organic anion transporter (S-glutathionyl-2-4-dinitrobenzene)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycolithocholic acidReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of glycolithocholate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• gamma-Glu-AlaReach from here →
  1. transport of GSH and serotonin (cytosol to extracellular)
  2. gamma-glutamyltransferase (alanine)

  Catalysed by SLCO1A2, SLCO1B3, GGT1, GGT5 and 4 moreextracellular space, cytosol

• taurineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. bile acid-CoA:amino acid N-acyltransferase (taurodeoxycholate)

  Catalysed by AANAT, BAATcytosolOne of 2 routes

• 3,3',5-triiodo-L-thyronineReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3extracellular space, cytosolOne of 4 routes

• glycineReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. glycine N-acyltransferase (N-arachidonoylglycine)

  Catalysed by AANAT, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 10 routes

• (R)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)

  Catalysed by AANAT, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

• (S)-methylmalonyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by AANATcytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by AANAT, ACP2cytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by AANATcytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by AANAT, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

• (6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (gamma-linolenate)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes

• butanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by AANAT, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes

• glutaryl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Production of Glutaryl Carnitine

  Catalysed by AANAT, CPT1A, CPT1C, CPT1BcytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 12 routes

• itaconyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by AANAT, SUCLG1, SUCLG2, SUCLA2cytosol, mitochondrial matrixOne of 2 routes

• (9Z,12Z)-octadecadienoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 13 routes

• tetradecanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

• octanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. Octanoyl-CoA:L-carnitine O-octanoyltransferase

  Catalysed by AANAT, CROTcytosol, mitochondrial matrixOne of 20 routes

• phytanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. phytanate-CoA ligase

  Catalysed by AANATcytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. acetyl-CoA:aralkylamine N-acetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by AANAT, SLC27A2, ACSL4, ACSL3 and 4 morecytosolOne of 15 routes

• prostaglandin E1Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of prostaglandin E1 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin I2Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of prostaglandin I2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin F2alphaReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of prostaglandin F2alpha (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin H2Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of prostaglandin H2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• prostaglandin D2Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of prostaglandin D2 (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLCO1B1extracellular space, cytosolOne of 4 routes

• (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. transport of GSH and serotonin (cytosol to extracellular)
  2. Glutathione: 15-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosol