4-hydroxy-2-oxoglutaric acid

Three steps

• 3-hydroxy-L-kynurenineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 3-hydroxy-L-kynurenine + H2O = 3-hydroxyanthranilate + L-alanine + H(+)

  Catalysed by HOGA1, AGXT2, KYNUmitochondrial matrix

• L,L-cystathionineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by HOGA1, CLYBL, NAGSmitochondrial matrix

• L-homocysteineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by HOGA1, TYW1B, TYW1, BHMT2mitochondrial matrix

• S-methyl-L-methionineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methyl-L-methionine + L-homocysteine = 2 L-methionine + H(+)

  Catalysed by HOGA1, TYW1B, TYW1, BHMT2mitochondrial matrix

• N-acetylputrescineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N-acetylputrescine + H2O = putrescine + acetate

  Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosol

• (2R)-2-phosphoglycerateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. pyruvate kinase (dTDP)
  3. 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)

  Catalysed by HOGA1, PKM, PKLR, ENO1 and 2 moremitochondrial matrix, cytosol

• L-tyrosineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. L-tyrosine + glyoxylate = 3-(4-hydroxyphenyl)pyruvate + glycine

  Catalysed by HOGA1, AGXT, AGXT2, AADATmitochondrial matrix

• N(omega),N(omega)-dimethyl-L-arginineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. N(omega),N(omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by HOGA1, AGXT, AGXT2mitochondrial matrixOne of 8 routes

• an acyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by HOGA1, CLYBL, ASAH1, ACER2 and 2 moremitochondrial matrix, Golgi apparatusOne of 2 routes

• trans-4-hydroxy-L-prolineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by HOGA1, AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• kynurenateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. 2-oxo-3-sulfanylpropanoate + [thioredoxin]-dithiol = [thioredoxin]-disulfide + hydrogen sulfide + pyruvate + H(+)
  3. 2-oxo-3-sulfanylpropanoate + L-kynurenine = kynurenate + L-cysteine + H2O

  Catalysed by HOGA1, MPST, AADATmitochondrial matrixOne of 2 routes

• N(8)-acetylspermidineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(8)-acetylspermidine + H2O = spermidine + acetate

  Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosol

• (3Z)-dodecenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by HOGA1, CLYBL, HADHA, ACAA2 and 1 moremitochondrial matrixOne of 3 routes

• (S)-3-amino-2-methylpropanoateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase

  Catalysed by HOGA1, AGXT2, ABATmitochondrial matrix

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by HOGA1, CLYBL, SLC27A2, SLC27A5mitochondrial matrix, endoplasmic reticulumOne of 3 routes

• phosphoenolpyruvateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. Pyruvate:carbon-dioxide ligase (ADP-forming)
  3. oxaloacetate + GTP = phosphoenolpyruvate + GDP + CO2

  Catalysed by HOGA1, PC, PCK1, PCK2mitochondrial matrix

• an N-acetyl-L-cysteine-S-conjugateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. an N-acetyl-L-cysteine-S-conjugate + H2O = an S-substituted L-cysteine + acetate

  Catalysed by HOGA1, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosol

• L-methionine (S)-S-oxideReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by HOGA1, TYW1B, TYW1, MSRAmitochondrial matrix

• L-methionine (R)-S-oxideReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by HOGA1, TYW1B, TYW1, MSRB3 and 2 moremitochondrial matrix

• deoxycholoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by HOGA1, CLYBL, SLC27A2, SLC27A5mitochondrial matrix, cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by HOGA1, AGXT, AGXT2, GLYATL2mitochondrial matrixOne of 2 routes

• (2S)-2-phospholactateReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (2S)-2-phospholactate + H2O = (S)-lactate + phosphate

  Catalysed by HOGA1, LDHA, LDHB, LDHC and 3 moremitochondrial matrixOne of 2 routes

• L-prolineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by HOGA1, AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• prostaglandin E2Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

  Catalysed by HOGA1, LDHA, LDHB, LDHC and 3 moremitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. L-Alanine:glyoxylate aminotransferase
  3. Hippurate (Benzoylglycinate) Formation

  Catalysed by HOGA1, AGXT, AGXT2mitochondrial matrixOne of 2 routes

• decanoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by HOGA1, CLYBL, ACSM4, ACSM1 and 4 moremitochondrial matrix, cytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Carnitine O-Palmitoyltransferase

  Catalysed by HOGA1, CLYBL, CPT1A, CPT1C and 1 moremitochondrial matrix, cytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 11 routes

• L-cysteinylglycineReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. gamma-glutamyltransferase (alanine)

  Catalysed by HOGA1, AGXT2, GGTLC3, GGT1 and 4 moremitochondrial matrix, cytosolOne of 2 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by HOGA1, CLYBL, CPT1A, CPT1Bmitochondrial matrix, cytosol

• dTMPReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. pyruvate kinase (dTDP)
  3. DTDP Diphosphohydrolase

  Catalysed by HOGA1, PKM, PKLR, ENTPD3 and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 5 routes

• CHEBI:63544Reach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 9 routes

• Mo-molybdopterinReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by HOGA1, AGXT2, MOCOSmitochondrial matrix

• (2E)-octadecenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. Carnitine O-Palmitoyltransferase

  Catalysed by HOGA1, CLYBL, CPT1A, CPT1C and 1 moremitochondrial matrix, cytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 8 routes

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)
  2. acetyl-CoA[m] + glyoxalate[m] + H2O[m] = CoA[m] + H+[m] + malate[m]
  3. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by HOGA1, CLYBL, SLC27A2, ACSL4 and 6 moremitochondrial matrix, cytosolOne of 7 routes