hydrogen cyanide

Three steps

• (R)-3-aminoisobutyric acidReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)

  Catalysed by MPST, TST, AGXT2, ABATcytosol, mitochondrial matrixOne of 3 routes

• L-citrullineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and citrulline (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• ubiquinonesReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. transport of fumarate and sulfite (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by MPST, TST, SLC25A10, SDHD and 3 moremitochondrial matrix, cytosol

• L-valineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and valine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 9 routes

• L-arginineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and arginine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• CHEBI:16497Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. pyruvate kinase (dTDP)
  3. dGTP:pyruvate 2-O-phosphotransferase

  Catalysed by MPST, TST, PKM, PKLRcytosol

• protein polypeptide chainReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. PROTEIN_BS

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 2 routes

• N(2)-acetyl-L-ornithineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N2-Acetyl-L-ornithine amidohydrolase

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• CHEBI:16633Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by MPST, TST, AGXT2, SCLYcytosol, mitochondrial matrix

• Met-tRNA(Met)Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. L-Methionine:tRNAMet ligase (AMP-forming)

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol

• (R)-glycerateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. L-Serine:pyruvate aminotransferase
  3. D-glycerate:NADP+ 2-oxidoreductase

  Catalysed by MPST, TST, AGXT, GRHPRcytosolOne of 4 routes

• quinolinic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Transport of Quinolinic Acid

  Catalysed by MPST, TST, SUOX, SLC22A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

• 4-methylsulfanyl-2-oxobutanoateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. glyoxylate + L-methionine = 4-methylsulfanyl-2-oxobutanoate + glycine

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol

• N-[(S)-lactoyl]-L-phenylalanineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

  Catalysed by MPST, TST, LDHA, LDHB and 4 morecytosol

• CHEBI:16856Reach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. S-sulfanylglutathione + O2 + H2O = sulfite + glutathione + 2 H(+)
  3. Persulfide dioxygenase

  Catalysed by MPST, TST, ETHE1mitochondrial matrix

• CHEBI:16857Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and threonine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 7 routes

• oxalic acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. transport of oxalate and sulfate (cytosol to extracellular)

  Catalysed by MPST, TST, SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular space

• glycolaldehydeReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. L-Serine:pyruvate aminotransferase
  3. hydroxypyruvate carboxy-lyase (glycolaldehyde-forming)

  Catalysed by MPST, TST, AGXTcytosolOne of 2 routes

• aldehydo-N-acetyl-D-mannosamineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)

  Catalysed by MPST, TST, NPLcytosolOne of 2 routes

• L-isoleucineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and isoleucine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• CHEBI:17203Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and proline (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 6 routes

• 17alpha-hydroxyprogesteroneReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space, endoplasmic reticulum

• enol-oxaloacetateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-malate + NAD(+) = pyruvate + CO2 + NADH
  3. (S)-malate + a quinone = enol-oxaloacetate + a quinol

  Catalysed by MPST, TST, ME2, SDHB and 1 morecytosol

• AH2Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by MPST, TST, AGXT2, MOCOScytosol, mitochondrial matrixOne of 7 routes

• L-cysteineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and cysteine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 21 routes

• 3,3'-diiodo-L-thyronine sulfateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. sulfite:ferricytochrome-c oxidoreductase
  3. Steryl-Sulfatase

  Catalysed by MPST, TST, SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

• Ala-tRNA(Ala)Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. L-Alanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by MPST, TST, AGXT2, AARS1cytosol, mitochondrial matrix

• 4-methylumbelliferyl acetateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. 4-methylumbelliferyl acetate + H2O = 4-methylumbelliferone + acetate + H(+)

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 6 morecytosol, extracellular space

• urateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (S)-Lactate:NAD+ oxidoreductase
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by MPST, TST, LDHB, LDHAL6B and 1 morecytosol, mitochondrial matrix, extracellular spaceOne of 3 routes

• methylarsonous acidReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GSTO1 and 1 moremitochondrial matrix

• CHEBI:17895Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and tyrosine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A5cytosol, mitochondrial matrix, extracellular spaceOne of 8 routes

• all-trans-retinalReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of pyruvate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by MPST, TST, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 3-phenylpyruvateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. L-Glutamine:pyruvate aminotransferase
  3. 3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

  Catalysed by MPST, TST, KYAT1cytosol

• CHEBI:18019Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and lysine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC7A6cytosol, mitochondrial matrix, extracellular spaceOne of 4 routes

• 4-fumarylacetoacetateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. transport of acetoacetate and pyruvate (cytosol to mitochondria)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by MPST, TST, FAHcytosol, mitochondrial matrixOne of 2 routes

• L-glutamineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. transport of alanine and glutamine (cytosol to extracellular)

  Catalysed by MPST, TST, AGXT2, SLC3A2 and 2 morecytosol, mitochondrial matrix, extracellular spaceOne of 17 routes

• dTTPReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. pyruvate kinase (dTDP)
  3. DTTP Nucleotidohydrolase

  Catalysed by MPST, TST, PKM, PKLR and 3 morecytosol, extracellular spaceOne of 11 routes

• CHEBI:18095Reach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. Transport of Hydroxy-Proline

  Catalysed by MPST, TST, AGXT2, SLC1A4cytosol, mitochondrial matrix, extracellular space

• arsenic triglutathioneReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by MPST, TST, TSTD1, AS3MTmitochondrial matrixOne of 3 routes

• S-methylmercury-L-cysteineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by MPST, TST, TYW1B, TYW1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-(alpha-Hydroxypropyl)thiamine diphosphateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate
  3. branched chain keto acid dehydrogenase E1 (2-oxobutyrate)

  Catalysed by MPST, TST, AGXT2, BCKDHA and 1 morecytosol, mitochondrial matrix

• 2-aminoisobutanoateReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by MPST, TST, AGXT2, SLC7A10cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• D-isoleucineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. D-serine = pyruvate + NH4(+)
  3. D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

  Catalysed by MPST, TST, SRR, SLC7A10cytosol, inner side of the membrane, outer side of the membrane

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by MPST, TST, TSTD1, MGST3mitochondrial matrix

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 1 moremitochondrial matrix

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 1 moremitochondrial matrix

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 1 moremitochondrial matrix

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX1 and 1 moremitochondrial matrix

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. thiosulfate:cyanide sulfurtranserase
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by MPST, TST, TSTD1, GPX4mitochondrial matrix

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. 3-mercaptopyruvate sulfurtransferase (hydrogen-cyanide)
  2. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by MPST, TST, AGXT2cytosol, mitochondrial matrixOne of 3 routes