L-glutamine

Two steps

• (3Z)-dodecenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

• S-sulfanyl-L-cysteineReach from here →
  1. transport of cysteine and glutamine (cytosol to extracellular)
  2. 2 L-cysteine = S-sulfanyl-L-cysteine + L-alanine

  Catalysed by SLC3A2, SLC7A5, SLC7A10, CARS2extracellular space, cytosol

• N-formyl-L-kynurenineReach from here →
  1. transport of glutamine and tryptophan (cytosol to extracellular)
  2. L-tryptophan + O2 = N-formyl-L-kynurenine

  Catalysed by SLC7A5, IDO1, TDO2, IDO2extracellular space, cytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by SLC27A2, SLC27A5cytosol, endoplasmic reticulumOne of 3 routes

• L-methionine (S)-S-oxideReach from here →
  1. transport of glutamine and methionine (cytosol to extracellular)
  2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A5, MSRAextracellular space, cytosol

• L-methionine (R)-S-oxideReach from here →
  1. transport of glutamine and methionine (cytosol to extracellular)
  2. [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol

  Catalysed by SLC7A5, MSRB3, MSRB1, MSRB2extracellular space, cytosol

• 5-amino-2-oxopentanoateReach from here →
  1. transport of glutamine and ornithine (cytosol to extracellular)
  2. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by SLC7A6, AGXT2extracellular space, cytosolOne of 2 routes

• deoxycholoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by SLC27A2, SLC27A5cytosolOne of 4 routes

• N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycineReach from here →
  1. transport of glutamine and glycine (cytosol to extracellular)
  2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + glycine = N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine + CoA + H(+)

  Catalysed by SLC7A5, GLYATL2extracellular space, cytosolOne of 2 routes

• N-[(R)-4-phosphopantothenoyl]-L-cysteineReach from here →
  1. transport of cysteine and glutamine (cytosol to extracellular)
  2. (R)-4'-phosphopantothenate:L-cysteine ligase

  Catalysed by SLC3A2, SLC7A5, SLC7A10, PPCSextracellular space, cytosolOne of 4 routes

• 4-aminobutanoateReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by SLC6A14, SLC6A12extracellular space, cytosolOne of 4 routes

• 3-iodo-L-tyrosineReach from here →
  1. transport of glutamine and tyrosine (cytosol to extracellular)
  2. thyroid peroxidase (iodine)

  Catalysed by SLC7A5, TPOextracellular space, cytosolOne of 2 routes

• L-prolineReach from here →
  1. L-Glutamine:pyruvate aminotransferase
  2. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by KYAT1, SLC1A4cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• N-benzoylglycineReach from here →
  1. transport of glutamine and glycine (cytosol to extracellular)
  2. Hippurate (Benzoylglycinate) Formation

  Catalysed by SLC7A5extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. transport of cysteine and glutamine (cytosol to extracellular)
  2. L-Cysteine:oxygen oxidoreductase

  Catalysed by SLC3A2, SLC7A5, SLC7A10, CDO1extracellular space, cytosolOne of 6 routes

• decanoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACSM4, ACSM1, ACSM2A, ACSM3 and 2 morecytosolOne of 7 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 11 routes

• L-cysteinylglycineReach from here →
  1. L-Glutamine:pyruvate aminotransferase
  2. gamma-glutamyltransferase (alanine)

  Catalysed by KYAT1, GGTLC3, GGT1, GGT5 and 3 morecytosolOne of 2 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by CPT1A, CPT1Bcytosol

• CHEBI:63544Reach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• hexacosanoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• tetracosanoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 10 routes

• docosanoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes

• N(5)-[(Z)-amino(hydroxyimino)methyl]ornithineReach from here →
  1. transport of arginine and glutamine (cytosol to extracellular)
  2. L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)

  Catalysed by SLC7A6, NOS3, NOS1, NOS2extracellular space, cytosol

• Mo-molybdopterinReach from here →
  1. L-Glutamine:pyruvate aminotransferase
  2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by KYAT1, MOCOScytosol

• (2E)-octadecenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 8 routes

• L-threonylcarbamoyladenylateReach from here →
  1. L-threonine(in) + L-glutamine(out) + Na(+)(out) = L-threonine(out) + L-glutamine(in) + Na(+)(in)
  2. L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O

  Catalysed by SLC1A5, YRDCinner side of the membrane, outer side of the membrane

• (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (EPA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 9 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DPA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (9Z,12Z,15Z)-octadecatrienoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (linolenate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• (13Z)-docosenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (11Z)-eicosenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 4 routes

• (15Z)-tetracosenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (nervonic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (17Z)-hexacosenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (ximenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 4 routes

• (8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• (8Z,11Z,14Z,17Z)-eicosatetraenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (omega-3-arachidonic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (DHA)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 7 routes

• heptadecanoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (margaric acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (9Z)-heptadecenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (9-heptadecylenic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• (11Z,14Z,17Z)-eicosatrienoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase ((11Z,14Z,17Z)-eicosatrienoic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 5 routes

• (2S)-2-aminobutanoateReach from here →
  1. L-Glutamine:pyruvate aminotransferase
  2. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by KYAT1, AGXT2cytosolOne of 2 routes

• nonadecanoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)

  Catalysed by SLC27A2, ACSL4, ACSL3, ACSL1 and 4 morecytosolOne of 6 routes

• (11Z)-octadecenoyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

• dodecanedioyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. Activation of dodecanedioic acid

  No catalyst recordedcytosolOne of 4 routes

• decanedioyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. Production of Sebacoylcarnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes

• octanedioyl-CoAReach from here →
  1. Phenylacetyl-CoA:L-glutamine alpha-N-phenylacetyltransferase
  2. Production of Suberylcarnitine

  Catalysed by CPT1A, CPT1C, CPT1BcytosolOne of 4 routes