What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- HSD17B4ProteinUNIPROT:P51659substrate ofInferred only27 paths27 endpoints
- ACAA1ProteinUNIPROT:P09110substrate ofInferred only24 paths24 endpoints
- EHHADHProteinUNIPROT:Q08426substrate ofInferred only21 paths21 endpoints
- ACOT8ProteinUNIPROT:O14734substrate ofInferred only16 paths16 endpoints
- ACOX1ProteinUNIPROT:Q15067substrate ofInferred only15 paths15 endpoints
- CPT1BProteinUNIPROT:Q92523substrate ofInferred only8 paths8 endpoints
- CROTProteinUNIPROT:Q9UKG9substrate ofInferred only7 paths7 endpoints
- CPT1CProteinUNIPROT:Q8TCG5substrate ofInferred only4 paths4 endpoints
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: dodecanedioyl-CoA · Sources: Human-GEM
- dodecanedioyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR05100Inferred only
- dodecanedioyl-CoA is a substrate of ACOT8ProteinHuman-GEM MAR04509Inferred only
- dodecanedioyl-CoA is a substrate of ACOX1ProteinHuman-GEM MAR05100Inferred only
- dodecanedioyl-CoA is a substrate of CPT1AProteinHuman-GEM MAR05104Inferred only
- dodecanedioyl-CoA is a substrate of CPT1BProteinHuman-GEM MAR05104Inferred only
- dodecanedioyl-CoA is a substrate of CPT1CProteinHuman-GEM MAR05104Inferred only
- dodecanedioyl-CoA is a substrate of CROTProteinHuman-GEM MAR05106Inferred only
- dodecanedioyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR05100Inferred only
- dodecanedioyl-CoA is a substrate of HSD17B4ProteinHuman-GEM MAR05100Inferred only
Reactions
11 reactions
water+dodecanedioyl-CoACHEBI:1146900+proton+MAM03562x
Catalysed by ACOT8
Reaction pageLeft to rightBalancedEC 3.1.2.-GO:0005777
Human-GEM MAR04509CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM03562cAMP+diphosphate(3-)+dodecanedioyl-CoA
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR04511CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+dodecanedioyl-CoACHEBI:15351+FADH2+proton+NADH(2-)+decanedioyl-CoA
Catalysed by ACAA1 & HSD17B4 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedGO:0005777
Human-GEM MAR05100CC BY 4.0Reference data
(S)-carnitine+dodecanedioyl-CoACHEBI:1146900+MAM03490c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21GO:0005829
Human-GEM MAR05104CC BY 4.0Reference data
(S)-carnitine+dodecanedioyl-CoACHEBI:1146900+MAM03490x
Catalysed by CROT
Reaction pageReversibleBalancedEC 2.3.1.137GO:0005777
Human-GEM MAR05106CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+tetradecanedioyl-CoACHEBI:15351+FADH2+proton+NADH(2-)+dodecanedioyl-CoA
Catalysed by ACAA1 & HSD17B4 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedGO:0005777
Human-GEM MAR05182CC BY 4.0Reference data
dodecanedioyl-CoA+dioxygenCHEBI:76340+hydrogen peroxide
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:39071CC BY 4.0Reference data
CHEBI:76273+ATP(4-)+coenzyme A(4-)dodecanedioyl-CoA+AMP+diphosphate(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:40239CC BY 4.0Reference data
dodecanedioyl-CoA+ACHEBI:76340+AH2
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:40303CC BY 4.0Reference data
CHEBI:77041+coenzyme A(4-)dodecanedioyl-CoA+acetyl-CoA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:40347CC BY 4.0Reference data
dodecanedioyl-CoA+waterCHEBI:76273+coenzyme A(4-)+hydron
Catalysed by ACOT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:40595CC BY 4.0Reference data