Compound
octanedioyl-CoA
An acyl-CoA oxoanion that is the pentaanion of octanedioyl-CoA, arising from deprotonation of the phosphate, diphosphate and carboxylic acid OH groups.
Definition from ChEBI (CHEBI:76317), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
11 entities
11 entities reached.
0 reported hops11 assembled from the scaffold
- HSD17B4ProteinUNIPROT:P51659substrate ofInferred only54 paths27 endpoints
- EHHADHProteinUNIPROT:Q08426substrate ofInferred only42 paths21 endpoints
- ACOX1ProteinUNIPROT:Q15067substrate ofInferred only30 paths15 endpoints
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- ACAA1ProteinUNIPROT:P09110substrate ofInferred only24 paths24 endpoints
- ACOT8ProteinUNIPROT:O14734substrate ofInferred only16 paths16 endpoints
- GLYATProteinUNIPROT:Q6IB77substrate ofInferred only15 paths15 endpoints
- ACOX3ProteinUNIPROT:O15254substrate ofInferred only11 paths11 endpoints
- CPT1BProteinUNIPROT:Q92523substrate ofInferred only8 paths8 endpoints
- CROTProteinUNIPROT:Q9UKG9substrate ofInferred only7 paths7 endpoints
- CPT1CProteinUNIPROT:Q8TCG5substrate ofInferred only4 paths4 endpoints
What the reference databases state
Statements
14 statements
14 statements · 1 reference database · Subject: octanedioyl-CoA · Sources: Human-GEM
- octanedioyl-CoA is a substrate of ACAA1ProteinHuman-GEM MAR06345Inferred only
- octanedioyl-CoA is a substrate of ACOT8ProteinHuman-GEM MAR06777Inferred only
- octanedioyl-CoA is a substrate of ACOX1ProteinHuman-GEM MAR06345Inferred only
- octanedioyl-CoA is a substrate of ACOX1ProteinHuman-GEM MAR11539Inferred only
- octanedioyl-CoA is a substrate of ACOX3ProteinHuman-GEM MAR11539Inferred only
- octanedioyl-CoA is a substrate of CPT1AProteinHuman-GEM MAR04759Inferred only
- octanedioyl-CoA is a substrate of CPT1BProteinHuman-GEM MAR04759Inferred only
- octanedioyl-CoA is a substrate of CPT1CProteinHuman-GEM MAR04759Inferred only
- octanedioyl-CoA is a substrate of CROTProteinHuman-GEM MAR06832Inferred only
- octanedioyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR11539Inferred only
- octanedioyl-CoA is a substrate of EHHADHProteinHuman-GEM MAR06345Inferred only
- octanedioyl-CoA is a substrate of GLYATProteinHuman-GEM MAR11562Inferred only
Show the remaining 2
- octanedioyl-CoA is a substrate of HSD17B4ProteinHuman-GEM MAR11539Inferred only
- octanedioyl-CoA is a substrate of HSD17B4ProteinHuman-GEM MAR06345Inferred only
Reactions
12 reactions
(S)-carnitine+octanedioyl-CoACHEBI:1146900+MAM03502c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21GO:0005829
Human-GEM MAR04759CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+decanedioyl-CoACHEBI:15351+FADH2+proton+NADH(2-)+octanedioyl-CoA
Catalysed by ACAA1 & HSD17B4 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedGO:0005777
Human-GEM MAR05026CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+octanedioyl-CoACHEBI:15351+FADH2+proton+NADH(2-)+hexanedioyl-CoA
Catalysed by ACAA1 & HSD17B4 & EHHADH & ACOX1
Reaction pageLeft to rightBalancedGO:0005777
Human-GEM MAR06345CC BY 4.0Reference data
water+octanedioyl-CoACHEBI:1146900+proton+MAM03954x
Catalysed by ACOT8
Reaction pageLeft to rightBalancedEC 3.1.2.-GO:0005777
Human-GEM MAR06777CC BY 4.0Reference data
(S)-carnitine+octanedioyl-CoACHEBI:1146900+MAM03502x
Catalysed by CROT
Reaction pageReversibleBalancedEC 2.3.1.137GO:0005777
Human-GEM MAR06832CC BY 4.0Reference data
ATP+CHEBI:1146900+MAM03954cAMP+diphosphate(3-)+octanedioyl-CoA
Reaction pageLeft to rightBalancedGO:0005829
Human-GEM MAR06833CC BY 4.0Reference data
FAD+water+octanedioyl-CoAFADH2+MAM03261x
Catalysed by EHHADH & ACOX1 or HSD17B4 & ACOX1 or ACOX3 & EHHADH or ACOX3 & HSD17B4
Reaction pageLeft to rightBalancedEC 1.3.3.6, 4.2.1.17GO:0005777
Human-GEM MAR11539CC BY 4.0Reference data
glycine+octanedioyl-CoACHEBI:1146900+proton+MAM03955c
Catalysed by GLYAT
Reaction pageLeft to rightBalancedEC 2.3.1.13GO:0005829
Human-GEM MAR11562CC BY 4.0Reference data
octanedioyl-CoA+dioxygenCHEBI:76330+hydrogen peroxide
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:22952CC BY 4.0Reference data
CHEBI:76349+coenzyme A(4-)octanedioyl-CoA+acetyl-CoA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:39099CC BY 4.0Reference data
octanedioyl-CoA+waterCHEBI:76282+coenzyme A(4-)+hydron
Catalysed by ACOT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:40587CC BY 4.0Reference data
CHEBI:76282+ATP(4-)+coenzyme A(4-)octanedioyl-CoA+AMP+diphosphate(3-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:49600CC BY 4.0Reference data
Other names
7 names
Resolves to: octanedioyl-CoA
- Also called
- octanedioyl-coenzyme A(5-)octanedioyl-coenzyme A(5−)suberoyl-CoA(5-)suberoyl-CoA(5−)suberoyl-coenzyme A(5-)suberoyl-coenzyme A(5−)
- Systematic name
- 3'-phosphonatoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxylatoheptanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] diphosphate}