3,3',5'-triiodo-L-thyronine sulfate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

181 compounds within 3 steps: 3 in 1, 17 in 2, 161 in 3

Three steps

hypochlorous acidReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Peroxidase
Catalysed by DIO1, SLC26A4, LPOextracellular space, cytosolOne of 4 routes
potassium atomReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of chloride (cytosol to extracellular)
Catalysed by DIO1, SLC26A4, SLC12A2, SLC12A1extracellular space, cytosolOne of 2 routes
folic acidReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. dihydrofolate:NAD+ oxidoreductase
Catalysed by DIO1, MTO1, DHFR, DHFR2cytosolOne of 4 routes
N-acetyl-L-cysteineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. N-acetylglutamate synthase (N-acetyl-L-cysteine)
Catalysed by DIO1, MOCOS, NAGSmitochondrial matrix
a dicarboxylateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A35, SLC25A34Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
K(+)Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)
Catalysed by DIO1, MOCOS, SLC1A1inner side of the membrane, outer side of the membraneOne of 2 routes
Cys-tRNA(Cys)Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)
Catalysed by DIO1, MOCOS, CARS1cytosol
hydrogenselenideReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by DIO1, AIFM1, PYROXD1, SCLY
hydrogen sulfideReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-cysteine hydrogen-sulfide-lyase (deaminating
Catalysed by DIO1, MOCOS, CTHcytosolOne of 2 routes
D-aspartateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
L-aspartateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. L-Aspartate:2-oxoglutarate aminotransferase
Catalysed by DIO1, D2HGDH, GOT2mitochondrial matrixOne of 7 routes
oxalateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC26A2 and 3 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
formic acidReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of chloride and formate (cytosol to extracellular)
Catalysed by DIO1, SLC26A4extracellular space, cytosolOne of 2 routes
citric acidReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)
Catalysed by DIO1, D2HGDH, CSmitochondrial matrixOne of 2 routes
maleateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
malonic acidReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Malonate Transport, Antiport with Chloride
Catalysed by DIO1, SLC26A4extracellular space, cytosolOne of 4 routes
4-hydroxy-2-oxoglutaric acidReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. D-aspartate:2-oxoglutarate aminotransferase
Catalysed by DIO1, D2HGDH, GOT2mitochondrial matrix
(2R,3R)-tartrateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
(S,S)-tartrateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
(3R)-citramalateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
(3S)-citramalateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC25A30Golgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
thiosulfateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)
Catalysed by DIO1, STS, SLC25A14, SLC25A30 and 2 moreGolgi apparatus, inner side of the membrane, outer side of the membraneOne of 2 routes
di-mu-sulfido-diiron(2+)Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. De novo synthesis of 2Fe2S
Catalysed by DIO1, MOCOS, NDUFAB1, FDXR and 5 moremitochondrial matrix
25-hydroxycholesterolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, CH25H
all-trans-4-oxoretinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. cytochrome P450 (retinol)
Catalysed by DIO1, RETSAT, CYP26A1cytosol
phosphoenolpyruvic acidReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. (R)-malate + A = oxaloacetate + AH2
3. GTP:oxaloacetate carboxy-lyase (adding GTP
Catalysed by DIO1, D2HGDH, PCK1cytosolOne of 2 routes
13-cis-retinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
3. retinol binding protein (retinol)
Catalysed by DIO1, RETSAT, RBP1, RBP2cytosolOne of 2 routes
L-ornithineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and ornithine (cytosol to extracellular)
Catalysed by DIO1, MOCOS, SLC7A6extracellular space, cytosolOne of 2 routes
taurineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
Catalysed by DIO1, SLC26A4, SLC6A6extracellular space, cytosolOne of 2 routes
all-trans-13,14-dihydroretinolReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. all-trans-13,14-dihydroretinol + A = all-trans-retinol + AH2
Catalysed by DIO1, AIFM1, PYROXD1, RETSATOne of 2 routes
3,3',5'-triiodo-L-thyronineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. 3,3',5'-triiodo-L-thyronine + iodide + A + H(+) = L-thyroxine + AH2
Catalysed by DIO1, AIFM1, PYROXD1, DIO3One of 2 routes
glycineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and glycine (cytosol to extracellular)
Catalysed by DIO1, MOCOS, SLC3A2, SLC7A5 and 1 moreextracellular space, cytosolOne of 7 routes
prostaglandin H2Reach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = prostaglandin H2 + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, PTGS1 and 1 moreOne of 2 routes
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + AH2 = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + A + H2O
Catalysed by DIO1, AIFM1, PYROXD1, TBXAS1 and 2 more
sarcosineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. sarcosine + O2 + H2O = formaldehyde + glycine + H2O2
Catalysed by DIO1, KDM1A, KDM1B, PIPOX
(6S)-5,6,7,8-tetrahydrofolateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
3. (6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)
Catalysed by DIO1, MTO1, DHFR, DHFR2
3,5-diiodo-L-tyrosineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. iodide:hydrogen-peroxide oxidoreductase
3. thyroid peroxidase (3-iodo-L-tyrosine)
Catalysed by DIO1, TPOcytosolOne of 2 routes
2-oxo-3-sulfanylpropanoateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-Cysteine:2-oxoglutarate aminotransferase
Catalysed by DIO1, MOCOS, GOT2, GOT1cytosolOne of 3 routes
S-formylglutathioneReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 A + 2 H2O = L-lysyl(4)-[histone H3] + 2 formaldehyde + 2 AH2
3. alcohol dehydrogenase (formaldehyde)
Catalysed by DIO1, KDM1A, KDM1B, ADH1C and 5 morecytosol
guanidinoacetateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. Transport of Guanidinoacetic Acid
Catalysed by DIO1, SLC26A4extracellular space, cytosol
L-methionineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)
Catalysed by DIO1, AIFM1, PYROXD1, CDK5RAP1One of 12 routes
N-sulfo-D-glucosamineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate
Catalysed by DIO1, STS, SGSHGolgi apparatus
dehydroepiandrosterone 3-sulfateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
Catalysed by DIO1, STSGolgi apparatus
L-tryptophanReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and tryptophan (cytosol to extracellular)
Catalysed by DIO1, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes
beta-alanineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. transport of chloride and iodide (cytosol to extracellular)
3. transport of beta-alanine and chloride (cytosol to extracellular)
Catalysed by DIO1, SLC26A4, SLC6A6, SLC6A14extracellular space, cytosolOne of 2 routes
L-alanineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. A + NADH + H(+) = AH2 + NAD(+)
3. L-selenocysteine + AH2 = hydrogenselenide + L-alanine + A + H(+)
Catalysed by DIO1, AIFM1, PYROXD1, SCLYOne of 19 routes
L-asparagineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of asparagine and cysteine (cytosol to extracellular)
Catalysed by DIO1, MOCOS, SLC7A5extracellular space, cytosolOne of 6 routes
L-phenylalanineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. transport of cysteine and phenylalanine (cytosol to extracellular)
Catalysed by DIO1, MOCOS, SLC7A5extracellular space, cytosolOne of 8 routes
gamma-L-glutamyl-L-cysteineReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
3. L-glutamate:L-cysteine gamma-ligase (ADP-forming)
Catalysed by DIO1, MOCOS, GCLC, GCLMcytosolOne of 2 routes
adenosine 5'-phosphosulfateReach from here →
1. 3,3'-diiodo-L-thyronine sulfate + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine sulfate + AH2
2. Steryl-Sulfatase
3. ATP:sulfate adenylyltransferase
Catalysed by DIO1, STS, PAPSS1, PAPSS2Golgi apparatus, cytosolOne of 4 routes