N-acetyl-L-aspartate

Three steps

• urateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and L-lactate (cytosol to extracellular)
  3. transport of L-lactate and urate (cytosol to extracellular)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• 5-hydroxy-L-tryptophanReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tryptophan + O2 = 5-hydroxy-L-tryptophan + (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin

  Catalysed by ASPA, ACY3, SLC7A13, TPH1 and 1 morecytosol, inner side of the membrane, outer side of the membrane

• 4-methyl-2-oxopentanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)
  3. L-Leucine:2-oxoglutarate aminotransferase

  Catalysed by ASPA, ACY3, SLC7A13, BCAT2cytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 4 routes

• CHEBI:17895Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and tyrosine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNS, SLC7A5cytosol, extracellular spaceOne of 34 routes

• all-trans-retinalReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and retinoate (cytosol to extracellular)
  3. retinoate reduction

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 1 morecytosol, extracellular space

• CHEBI:17927Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. N1,N8-diacetylspermidine to N1-acetylspermidine conversion

  Catalysed by ASPA, ACY3, NAT8Lcytosol, mitochondrial matrix

• 3-oxopropanoic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate 1-carboxy-lyase (beta-alanine-forming)
  3. beta-alanine:2-oxoglutarate aminotransferase

  Catalysed by ASPA, ACY3, GAD2, ABATcytosol, mitochondrial matrix

• 3-phenylpyruvateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. Phenylalanine Transaminase, Mitochondrial

  Catalysed by ASPA, ACY3, SLC7A13, GOT2 and 1 morecytosol, inner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 5 routes

• fumaric acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-Citrulline:L-aspartate ligase (AMP-forming)
  3. 2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)

  Catalysed by ASPA, ACY3, ASS1, ASLcytosolOne of 8 routes

• CHEBI:18019Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. transport of asparagine and lysine (cytosol to extracellular)

  Catalysed by ASPA, ACY3, ASNS, SLC7A6cytosol, extracellular spaceOne of 18 routes

• 4-fumarylacetoacetateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and acetoacetate (cytosol to extracellular)
  3. 4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• dTDPReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. pyruvate kinase (dTDP)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 5 morecytosol, extracellular space

• CHEBI:18095Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. Aspartate Intake by System Asct-1 Transporter
  3. prolyl 4-hydroxylase (AKG)

  Catalysed by ASPA, ACY3, P4HA2, P4HB and 1 morecytosol, extracellular space, endoplasmic reticulumOne of 4 routes

• 2-phenylethylamineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by ASPA, ACY3, SLC7A13, DDCcytosol, inner side of the membrane, outer side of the membrane

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by ASPA, ACY3, SLC7A13, PFAScytosol, inner side of the membrane, outer side of the membrane

• S-methylmercury-L-cysteineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)
  3. S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

  Catalysed by ASPA, ACY3, SLC7A13, SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 2-aminoisobutanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by ASPA, ACY3, AGXT2, SLC7A10cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular spaceOne of 8 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ASPA, ACY3, AGXT2cytosol

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and pyruvate (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 4 morecytosol, extracellular space

• (5Z)-dodecenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by ASPA, ACY3, NAT8L, HADHA and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• (7Z)-tetradecenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 8 routes

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by ASPA, ACY3, NAT8L, HADHA and 2 morecytosol, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by ASPA, ACY3, NAT8L, HADHA and 2 morecytosol, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by ASPA, ACY3, NAT8L, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by ASPA, ACY3, NAT8L, ECHS1 and 2 morecytosol, mitochondrial matrixOne of 2 routes

• folic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. Folate Transport by Oats

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 2 morecytosol, inner side of the membrane, outer side of the membrane, extracellular spaceOne of 2 routes

• CHEBI:27540Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by ASPA, ACY3, NAT8L, ACSM4 and 5 morecytosol, mitochondrial matrixOne of 6 routes

• 17alpha,21-dihydroxypregnenoloneReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450

  Catalysed by ASPA, ACY3, CYP17A1, CYP21A2cytosol, endoplasmic reticulum

• elaidic acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by ASPA, ACY3, NAT8L, SLC27A2 and 7 morecytosol, mitochondrial matrixOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by ASPA, ACY3, SLC7A13, TPH1 and 1 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 11-deoxycortisolReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxyprogesterone)
  3. cytochrome P450 (17alpha-hydroxyprogesterone)

  Catalysed by ASPA, ACY3, CYP17A1, CYP21A2cytosol, endoplasmic reticulumOne of 3 routes

• 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
  3. 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

  Catalysed by ASPA, ACY3, ASAH1, PLA2G15cytosolOne of 3 routes

• 3beta-hydroxyandrost-5-en-17-oneReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. cytochrome P450 (17alpha-hydroxypregnenolone)
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by ASPA, ACY3, CYP17A1cytosol, endoplasmic reticulumOne of 6 routes

• CHEBI:28701Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by ASPA, ACY3, NAT8L, ACAA1 and 2 morecytosol, mitochondrial matrix, peroxisomeOne of 7 routes

• pyridoxine 5'-phosphateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. oxaloacetate + L-alanine = L-aspartate + pyruvate
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by ASPA, ACY3, AGXT2, SCLYcytosol

• 3-disulfanyl-L-alanineReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by ASPA, ACY3, SLC7A13, CTHcytosol, inner side of the membrane, outer side of the membrane

• a dicarboxylateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 2 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• Ca(2+)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of aspartate (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by ASPA, ACY3, SLC1A7, SLC1A3 and 8 morecytosol, extracellular spaceOne of 3 routes

• Phe-tRNA(Phe)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)

  Catalysed by ASPA, ACY3, SLC7A13, FARSB and 1 morecytosol, inner side of the membrane, outer side of the membrane

• Trp-tRNA(Trp)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-Tryptophan -tRNA(Trp) ligase (AMP-forming)

  Catalysed by ASPA, ACY3, SLC7A13, WARS1cytosol, inner side of the membrane, outer side of the membrane

• Gln-tRNA(Gln)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)
  3. L-Glutamine:tRNA(Gln) ligase (AMP-forming)

  Catalysed by ASPA, ACY3, SLC7A13, QARS1cytosol, inner side of the membrane, outer side of the membrane

• Asn-tRNA(Asn)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate:L-glutamine amido-ligase (AMP-forming)
  3. L-Asparagine:tRNA(Asn) ligase (AMP-forming)

  Catalysed by ASPA, ACY3, ASNS, NARS1cytosol

• chlorine(.)Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. transport of acetate and formate (cytosol to extracellular)
  3. transport of chloride and formate (cytosol to extracellular)

  Catalysed by ASPA, ACY3, SLC16A4, SLC16A5 and 2 morecytosol, extracellular spaceOne of 24 routes

• D-aspartateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. K(+)(in) + L-aspartate(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-aspartate(in) + 3 Na(+)(in) + H(+)(in)
  3. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by ASPA, ACY3, SLC1A7, SLC1A3 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• CHEBI:30249Reach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)
  3. L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

  Catalysed by ASPA, ACY3, SLC7A13, IDO1 and 2 morecytosol, inner side of the membrane, outer side of the membrane

• oxalateReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by ASPA, ACY3, SLC25A14, SLC25A30 and 3 morecytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• citric acidReach from here →
  1. N-Acetyl-L-aspartate amidohydrolase
  2. L-Aspartate:2-oxoglutarate aminotransferase
  3. acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing)

  Catalysed by ASPA, ACY3, GOT2, CScytosol, mitochondrial matrixOne of 2 routes