N-[(S)-lactoyl]-L-phenylalanine

Three steps

• beta-carbolineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and tryptophan (cytosol to extracellular)
  3. beta-carboline hydrolysis

  Catalysed by CNDP2, SLC7A5extracellular space, cytosol

• (S)-carnitineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. Carnitine Transport by Atb0

  Catalysed by CNDP2, SLC6A14extracellular space, cytosol

• CHEBI:1146900Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. bile acid-CoA: amino acid N-acyltransferase

  Catalysed by CNDP2, SLC7A5, BAATextracellular space, cytosol, peroxisomeOne of 40 routes

• 2-hydroxybutyric acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 8 moreextracellular space, cytosolOne of 2 routes

• N(omega)-methyl-L-arginineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. N(omega)-methyl-L-arginine + glyoxylate = 5-(3-methylguanidino)-2-oxopentanoate + glycine

  Catalysed by CNDP2, SLC7A5, AGXT2extracellular space, cytosolOne of 4 routes

• 3-methyl-2-oxobutanoateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and valine (cytosol to extracellular)
  3. L-Valine:2-oxoglutarate aminotransferase

  Catalysed by CNDP2, SLC7A5, BCAT2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• AReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of cysteine and phenylalanine (cytosol to extracellular)
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by CNDP2, SLC7A5, MOCOSextracellular space, cytosol

• glycoursodeoxycholateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycine to glycoursodeoxycholate conversion

  Catalysed by CNDP2, SLC7A5extracellular space, cytosolOne of 2 routes

• prostaglandin A2Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)
  3. scavenger receptor class F (prostaglandin A2)

  Catalysed by CNDP2, SLCO2A1, SCARF2inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• prostaglandin J2Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. prostaglandin D2(out) + 2 (S)-lactate(in) = prostaglandin D2(in) + 2 (S)-lactate(out)
  3. prostaglandin J2 hydrolysis

  Catalysed by CNDP2, SLCO2A1inner side of the membrane, outer side of the membrane, cytosolOne of 2 routes

• 15-oxoprostaglandin F2alphaReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. prostaglandin F2alpha(out) + 2 (S)-lactate(in) = prostaglandin F2alpha(in) + 2 (S)-lactate(out)
  3. 15-keto-prostaglandin F2alpha reduction

  Catalysed by CNDP2, SLCO2A1inner side of the membrane, outer side of the membrane, cytosolOne of 3 routes

• 2,4-dinitrophenyl-S-glutathioneReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. prostaglandin E3(out) + 2 (S)-lactate(in) = prostaglandin E3(in) + 2 (S)-lactate(out)
  3. transport of prostaglandin E3 (cytosol to extracellular)

  Catalysed by CNDP2, SLCO2A1, SLCO1B1inner side of the membrane, outer side of the membrane, extracellular space, cytosolOne of 14 routes

• N-(9Z-octadecenoyl)glycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (9Z)-octadecenoyl-CoA + glycine = N-(9Z-octadecenoyl)glycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL3, GLYATL2extracellular space, cytosol

• N-(9Z-octadecenoyl)-L-leucineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of leucine and phenylalanine (cytosol to extracellular)
  3. N-(9Z-octadecenoyl)-L-leucine + H2O = L-leucine + (9Z)-octadecenoate

  Catalysed by CNDP2, SLC7A5, PM20D1extracellular space, cytosol

• N-octadecanoylglycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. octadecanoyl-CoA + glycine = N-octadecanoylglycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL2extracellular space, cytosol

• N-(9Z-hexadecenoyl)-glycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (9Z)-hexadecenoyl-CoA + glycine = N-(9Z-hexadecenoyl)-glycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL2extracellular space, cytosol

• acetoacetateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. transport of acetoacetate and pyruvate (cytosol to mitochondria)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 2 moremitochondrial matrix, cytosolOne of 4 routes

• N-hexadecanoylglycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL3extracellular space, cytosol

• N-dodecanoylglycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL2extracellular space, cytosol

• N-decanoylglycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL2extracellular space, cytosol

• N-octanoylglycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL2extracellular space, cytosol

• D-histidineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of ornithine and phenylalanine (cytosol to extracellular)
  3. D-histidine(in) + L-ornithine(out) + H(+)(in) = D-histidine(out) + L-ornithine(in) + H(+)(out)

  Catalysed by CNDP2, SLC7A6, SLC25A2extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• L-homoarginineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of arginine and phenylalanine (cytosol to extracellular)
  3. L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

  Catalysed by CNDP2, SLC7A6, SLC25A29extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-homocarnosineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. Formation of homocarnosine

  Catalysed by CNDP2, SLC7A6, CARNS1extracellular space, cytosolOne of 2 routes

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by CNDP2, SLC7A5, GARTextracellular space, cytosol

• L-cystine-bis-glycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. L-cystine-bis-glycine + 2 H2O = L-cystine + 2 glycine

  Catalysed by CNDP2, SLC7A5, DPEP1, DPEP2extracellular space, cytosol

• glycyldehydrophenylalanineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by CNDP2, SLC7A5, DPEP1extracellular space, cytosol

• 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

  Catalysed by CNDP2, SLC7A5, PFASextracellular space, cytosol

• kinetensin-(1-8)Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Chymase
  3. kinetensin + H2O = kinetensin-(1-8) + L-leucine

  Catalysed by CNDP2, CMA1, ACE2extracellular space

• an N-(fatty acyl)-glycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL2extracellular space, cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by CNDP2, SLC7A5, GLYATL2extracellular space, cytosol

• acetaldehydeReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and threonine (cytosol to extracellular)
  3. L-threonine acetaldehyde-lyase (glycine-forming)

  Catalysed by CNDP2, SLC7A5extracellular space, cytosol

• cholineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and choline (cytosol to extracellular)

  Catalysed by CNDP2, SLC6A14, SLC5A7extracellular space, cytosol

• acetylpyruvateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 more

• all-trans-retinoic acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. transport of pyruvate and retinoate (cytosol to extracellular)

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 8 moreextracellular space, cytosolOne of 2 routes

• CHEBI:15570Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by CNDP2, SLC7A5, SLC3A2, SLC7A10extracellular space, cytosolOne of 5 routes

• (S)-malateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (S)-malate + NAD(+) = pyruvate + CO2 + NADH

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 moreOne of 2 routes

• CHEBI:15611Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glycine and phenylalanine (cytosol to extracellular)
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by CNDP2, SLC7A5, GNMTextracellular space, cytosol

• trimethylenediamineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of lysine and phenylalanine (cytosol to extracellular)
  3. deoxyhypusine synthase (1,3-diaminopropane)

  Catalysed by CNDP2, SLC7A6, DHPSextracellular space, cytosol

• CHEBI:15727Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of histidine and phenylalanine (cytosol to extracellular)
  3. L-histidine:beta-alanine ligase (ADP-forming)

  Catalysed by CNDP2, SLC7A6, CARNS1extracellular space, cytosol

• CHEBI:15765Reach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. L-Tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)

  Catalysed by CNDP2, SLC7A5, THextracellular space, cytosolOne of 5 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by CNDP2, SLC7A13, CADinner side of the membrane, outer side of the membrane, cytosol

• alpha-D-glucosamine 6-phosphateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of glutamine and phenylalanine (cytosol to extracellular)
  3. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)

  Catalysed by CNDP2, SLC7A5, GFPT2, GFPT1extracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. L-Phenylalanine:tRNA(Ala) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by CNDP2, FARSB, FARSAcytosolOne of 2 routes

• sulfateReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. transport of chloride and sulfate (cytosol to extracellular)

  Catalysed by CNDP2, SLC6A14, SLC26A6extracellular space, cytosolOne of 3 routes

• ureaReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)
  3. Peroxidase

  Catalysed by CNDP2, SLC22A12, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 6 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. (S)-lactate + NAD(+) = pyruvate + NADH + H(+)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CNDP2, LDHA, LDHB, LDHC and 3 moremitochondrial matrix

• L-cystineReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. Transport of L-Cystine (L-Alanine antiport) by B0, +At Transporter

  Catalysed by CNDP2, SLC7A5, SLC7A9, SLC3A1extracellular space, cytosolOne of 9 routes

• (R)-3-aminoisobutyric acidReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of alanine and phenylalanine (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by CNDP2, SLC7A5, AGXT2extracellular space, cytosol, mitochondrial matrix

• iodideReach from here →
  1. (S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O
  2. transport of phenylalanine and tyrosine (cytosol to extracellular)
  3. thyroid peroxidase (iodine)

  Catalysed by CNDP2, SLC7A5, TPOextracellular space, cytosolOne of 3 routes