sulfate

Three steps

• dTDPReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. pyruvate kinase (dTDP)

  Catalysed by SLC25A10, ME2, ME3, PKM and 1 moremitochondrial matrix, cytosol

• O-octanoyl-(R)-carnitineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. solute carrier (L-carnitine)

  Catalysed by SLC26A6, SLC6A14, SLC25A20extracellular space, cytosol, mitochondrial matrixOne of 7 routes

• CHEBI:18132Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and choline (cytosol to extracellular)
  3. ATP:choline phosphotransferase

  Catalysed by SLC26A6, SLC5A7, CHKA, CHKBextracellular space, cytosol

• N(1)-(5-phospho-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5-Phospho-D-ribosylamine:glycine ligase (ADP-forming)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GARTextracellular space, cytosol

• arsenic triglutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

  Catalysed by SLC25A14, SLC25A30, TSTD1, AS3MTinner side of the membrane, outer side of the membraneOne of 3 routes

• 2-phenylethylamineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. L-phenylalanine carboxy-lyase (phenylethylamine-forming)

  Catalysed by SLC26A6, SLC6A14, DDCextracellular space, cytosol

• 2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Glutamine by Atb0 Transporter
  3. 5'-Phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)

  Catalysed by SLC26A6, SLC6A14, PFASextracellular space, cytosol

• ophthalmateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GSSextracellular space, cytosol

• S-methylmercury-L-cysteineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Phenylalanine by Atb0 Transporter
  3. S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

  Catalysed by SLC26A6, SLC6A14, SLC7A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 6 routes

• 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)Reach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. dehydroepiandrosterone 3-sulfate(out) + glutarate(in) = dehydroepiandrosterone 3-sulfate(in) + glutarate(out)
  3. 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(out) + glutarate(in) = 5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)(in) + glutarate(out)

  Catalysed by STS, SLC22A24, SLC22A8inner side of the membrane, outer side of the membraneOne of 2 routes

• 2-aminoisobutanoateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. 2-aminoisobutanoate(out) + L-alanine(in) = 2-aminoisobutanoate(in) + L-alanine(out)

  Catalysed by SLC26A6, SLC6A14, SLC7A10extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. 15-deoxy-Delta(12,14)-prostaglandin J2 + glutathione = 15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathione

  Catalysed by SLC25A14, SLC25A30, TSTD1, MGST3inner side of the membrane, outer side of the membrane

• (6R)-10-formyltetrahydrofolateReach from here →
  1. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  2. oxalate(in) + formate(out) = oxalate(out) + formate(in)
  3. (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate

  Catalysed by SLC25A14, SLC26A2, SLC25A30, SLC26A6 and 3 moreinner side of the membrane, outer side of the membrane

• (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, GPX1 and 1 moreinner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoate + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, GPX1 and 1 moreinner side of the membrane, outer side of the membrane

• (15S)-hydroxy-(11Z,13E)-eicosadienoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (15S)-hydroperoxy-(11Z,13E)-eicosadienoate + 2 glutathione = (15S)-hydroxy-(11Z,13E)-eicosadienoate + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, GPX1 and 1 moreinner side of the membrane, outer side of the membrane

• (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione = (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, GPX1 and 1 moreinner side of the membrane, outer side of the membrane

• a hydroxy-1,2-diacyl-glycero-3-phosphocholineReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. a hydroperoxy-1,2-diacyl-glycero-3-phosphocholine + 2 glutathione = a hydroxy-1,2-diacyl-glycero-3-phosphocholine + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, GPX4inner side of the membrane, outer side of the membrane

• 5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. transport of malate and OAA (cytosol to mitochondria)
  3. N(omega),N(omega)-dimethyl-L-arginine + oxaloacetate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-aspartate

  Catalysed by SLC25A10, AGXT2mitochondrial matrix, cytosolOne of 9 routes

• N(omega),N('omega)-dimethyl-L-arginineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. N(omega),N('omega)-dimethyl-L-arginine + glyoxylate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + glycine

  Catalysed by SLC26A6, SLC6A9, SLC6A14, AGXT2extracellular space, cytosolOne of 2 routes

• 5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 5-(3-methylguanidino)-2-oxopentanoateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

  Catalysed by SLC25A10, ME2, ME3, AGXT2mitochondrial matrix, cytosolOne of 2 routes

• 5,6,7,8-tetrahydrofolic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase

  Catalysed by SLC26A6, SLC6A9, SLC6A14, SHMT1extracellular space, cytosolOne of 5 routes

• S-disulfanyl-L-cysteineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. S-sulfanyl-L-cysteine + L-cysteine = S-disulfanyl-L-cysteine + L-alanine

  Catalysed by SLC26A6, SLC6A14, CARS2extracellular space, cytosol

• (5Z)-dodecenoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxomyrist-7-enoyl-CoA)

  Catalysed by SLC25A14, SLC25A30, NAT8L, HADHA and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (11Z)-docosenoyl-CoA(4-)Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (cis-cetoleic acid)

  Catalysed by SLC25A14, SLC25A30, NAT8L, SLC27A2 and 7 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• 3-iodo-L-thyronineReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. 3-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by STS, DIO1Golgi apparatus

• (7Z)-tetradecenoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase ((7Z)-tetradecenoic acid)

  Catalysed by SLC25A14, SLC25A30, NAT8L, SLC27A2 and 7 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 8 routes

• 3'-iodo-L-thyronineReach from here →
  1. Steryl-Sulfatase
  2. Steryl-Sulfatase
  3. 3'-iodo-L-thyronine + iodide + A + H(+) = 3,3'-diiodo-L-thyronine + AH2

  Catalysed by STS, DIO3Golgi apparatus

• (4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C18:4->C16:4), Mitochondrial

  Catalysed by SLC25A14, SLC25A30, NAT8L, HADHA and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 3 routes

• (7Z,10Z)-hexadecadienoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation Trans (C18:2->C16:2), Mitochondrial

  Catalysed by SLC25A14, SLC25A30, NAT8L, HADHA and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix

• (4Z,7Z)-decadienoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C12:3->C10:2), Mitochondrial

  Catalysed by SLC25A14, SLC25A30, NAT8L, ECHS1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• (5Z)-octenoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Fatty Acid Beta Oxidation (C10:2->C8:1), Mitochondrial

  Catalysed by SLC25A14, SLC25A30, NAT8L, ECHS1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrixOne of 2 routes

• 3-(glutathion-S-yl)-4-hydroxynonanalReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (E)-4-hydroxynon-2-enal + glutathione = 3-(glutathion-S-yl)-4-hydroxynonanal

  Catalysed by SLC25A14, SLC25A30, TSTD1, GSTP1inner side of the membrane, outer side of the membrane

• androst-5-en-3beta,17beta-diolReach from here →
  1. steroid sulfatase (5-alpha-dihydrotestosterone)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. 3beta-hydroxy-Delta(5)-steroid dehydrogenase (5-alpha-dihydrotestosterone)

  Catalysed by STS, HSD3B1, HSD3B2cytosolOne of 4 routes

• alpha-linolenic acidReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Carnitine Transport by Atb0
  3. Utilized Transport

  Catalysed by SLC26A6, SLC6A14extracellular space, cytosol, endoplasmic reticulum

• phenylacetylglycineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLC26A6, SLC6A9, SLC6A14, GLYATextracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLC25A14, SLC25A30, NAT8L, ACSM4 and 5 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 6 routes

• 3beta,16alpha-dihydroxy-androst-5-en-17-oneReach from here →
  1. steroid sulfatase (androsterone sulfate)
  2. steroid sulfatase (androsterone sulfate)
  3. hydroxysteroid 17-beta dehydrogenase (androsterone)

  Catalysed by STS, HSD17B7cytosol, endoplasmic reticulumOne of 2 routes

• elaidic acidReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLC25A14, SLC25A30, NAT8L, SLC27A2 and 7 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 5 routes

• 5-hydroxytryptophanReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of L-Tryptophan by Atb0 Transporter
  3. L-Tryptophan, Tetrahydrobiopterin:Oxygen Oxidoreductase (5-Hydroxylating)

  Catalysed by SLC26A6, SLC6A14, TPH1, TPH2extracellular space, cytosolOne of 2 routes

• CHEBI:28666Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and glycine (cytosol to extracellular)
  3. LTD4 hydrolysis

  Catalysed by SLC26A6, SLC6A9, SLC6A14extracellular space, cytosolOne of 3 routes

• CHEBI:28701Reach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. Propanoyl-CoA:acetyl-CoA C-acyltransferase

  Catalysed by SLC25A14, SLC25A30, NAT8L, ACAA1 and 2 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, peroxisomeOne of 7 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. Steryl-Sulfatase
  2. Pregnenolone-sulfate sulfohydrolase
  3. cytochrome P450 (pregnenolone)

  Catalysed by STS, CYP17A1Golgi apparatus, cytosolOne of 4 routes

• pyridoxine 5'-phosphateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of alanine and chloride (cytosol to extracellular)
  3. L-selenocysteine selenide-lyase (L-alanine-forming)

  Catalysed by SLC26A6, SLC6A14, SCLYextracellular space, cytosol

• 3-disulfanyl-L-alanineReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)
  3. L-cystine thiocysteine-lyase (deaminating

  Catalysed by SLC25A14, SLC25A30, SLC7A13, CTHinner side of the membrane, outer side of the membrane, cytosol

• N-acetyl-L-cysteineReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. N-acetylglutamate synthase (N-acetyl-L-cysteine)

  Catalysed by SLC26A6, SLC6A14, NAGSextracellular space, cytosol, mitochondrial matrix

• L-ascorbic acidReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by SLC25A14, SLC25A30, TSTD1, CLIC1 and 2 moreinner side of the membrane, outer side of the membrane

• Ca(2+)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLC26A6, SLC12A2, SLC12A1, SLC24A1 and 4 moreextracellular space, cytosolOne of 3 routes

• Cys-tRNA(Cys)Reach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of chloride and cysteine (cytosol to extracellular)
  3. L-Cysteine:tRNA(Cys) ligase (AMP-forming)

  Catalysed by SLC26A6, SLC6A14, CARS1extracellular space, cytosol