2,4-dinitrophenyl-S-glutathione

Three steps

• docosanoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• CHEBI:240943Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by SLCO1B1, GLYAT, GLYATL2, GLYATL1extracellular space, cytosol, mitochondrial matrix

• a quinolReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, SQORextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• octadecanoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• androst-5-en-3beta,17beta-diolReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. 3beta-hydroxyandrost-5-en-17-one + NADPH + H(+) = androst-5-en-3beta,17beta-diol + NADP(+)

  Catalysed by SLCO1B1, STS, AKR1B15, HSD17B3extracellular space, cytosol

• 5,6-dihydroxyindoleReach from here →
  1. transport of dopamine (cytosol to extracellular)
  2. Peroxidase
  3. peroxidase (dopamine-O-quinone)

  Catalysed by SLCO1A2, SLCO1B3, MPO, TPO and 2 moreextracellular space, cytosol, lysosome

• alpha-linolenic acidReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 13 routes

• folic acidReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. Folate Transport by Oats

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC22A8 and 1 moreextracellular space, cytosolOne of 2 routes

• phenylacetylglycineReach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. phenylacetyl-CoA:glycine N-phenylacetyltransferase

  Catalysed by SLCO1B1, GLYATextracellular space, cytosolOne of 3 routes

• CHEBI:27540Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. medium-chain acyl-CoA ligase (hexanoic acid)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, ACSM4 and 5 moreextracellular space, cytosolOne of 6 routes

• 3beta,16alpha-dihydroxy-androst-5-en-17-oneReach from here →
  1. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  2. 3beta-Hydroxyandrost-5-en-17-one 3-sulfate sulfohydrolase
  3. 3beta-hydroxyandrost-5-en-17-one + reduced [NADPH--hemoprotein reductase] + O2 = 3beta,16alpha-dihydroxy-androst-5-en-17-one + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by SLCO1B1, STS, CYP17A1, CYP3A7extracellular space, cytosol

• elaidic acidReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. acetyl-CoA:aralkylamine N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (elaidate)

  Catalysed by SLCO1A2, SLCO1B3, AANAT, SLC27A2 and 7 moreextracellular space, cytosolOne of 17 routes

• 1-methylimidazole-4-acetaldehydeReach from here →
  1. transport of histamine (cytosol to extracellular)
  2. S-Adenosyl-L-methionine:histamine N-tele-methyltransferase
  3. N-methylhistamine:oxygen oxidoreductase (deaminating)

  Catalysed by SLCO1A2, SLCO1B3, HNMT, AOC2 and 4 moreextracellular space, cytosolOne of 2 routes

• all-cis-docosa-4,7,10,13,16,19-hexaenoic acidReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• 5(S)-HETEReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. solute carrier organic anion transporter (cholate)
  3. Glutathione: 5-HPETE oxidoreductase

  Catalysed by SLCO1A2, SLCO1B3, GPX5, GPX1 and 7 moreextracellular space, cytosolOne of 4 routes

• 17alpha-hydroxypregnenoloneReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. cytochrome P450 (17alpha-hydroxypregnenolone)

  Catalysed by SLCO1B3, BCHE, ACHE, CYP17A1extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• Cu(2+)Reach from here →
  1. transport of dopamine (cytosol to extracellular)
  2. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O
  3. Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

  Catalysed by SLCO1A2, SLCO1B3, DBH, CYBRD1extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• L-ascorbic acidReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, CLIC1 and 2 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 10 routes

• Ca(2+)Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of Ca2+ and K+ (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4, SLC24A1 and 4 moreextracellular space, cytosolOne of 3 routes

• Gly-tRNA(Gly)Reach from here →
  1. transport of leukotriene C4 (cytosol to extracellular)
  2. leukotriene C4 hydrolysis
  3. glycine:tRNA(Gly) ligase (AMP-forming)

  Catalysed by SLCO1B1, GARS1extracellular space, cytosol

• hypoioditeReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)
  3. iodide + H2O2 = hypoiodite + H2O

  Catalysed by SLCO1A2, SLCO1B3, DIO1, DIO2 and 2 moreextracellular space, cytosol

• chlorine(.)Reach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of chloride (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4, SLC12A2 and 1 moreextracellular space, cytosolOne of 9 routes

• phosphocholineReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. phosphocholine + H2O = choline + phosphate

  Catalysed by SLCO1B3, BCHE, ACHE, PHOSPHO1extracellular space, cytosolOne of 2 routes

• hydrogen sulfideReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, TSTD1extracellular space, cytosol, inner side of the membrane, outer side of the membrane

• D-aspartateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. serotonin(out) + K(+)(in) + Na(+)(out) + H(+)(in) = serotonin(in) + K(+)(out) + Na(+)(in) + H(+)(out)
  3. D-aspartate(out) + K(+)(in) + 3 Na(+)(out) + H(+)(out) = D-aspartate(in) + K(+)(out) + 3 Na(+)(in) + H(+)(in)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4, SLC1A7 and 4 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 4 routes

• L-aspartateReach from here →
  1. transport of serotonin (cytosol to extracellular)
  2. transport of serotonin (cytosol to extracellular)
  3. transport of aspartate (cytosol to extracellular)

  Catalysed by SLCO1A2, SLCO1B3, SLC6A4, SLC1A7 and 4 moreextracellular space, cytosolOne of 5 routes

• oxalateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 4 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• formic acidReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. transport of acetate and formate (cytosol to extracellular)

  Catalysed by SLCO1B3, BCHE, ACHE, SLC16A4 and 2 moreextracellular space, cytosolOne of 4 routes

• propionic acidReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. transport of acetate and propanoate (cytosol to extracellular)

  Catalysed by SLCO1B3, BCHE, ACHE, SLC16A4 and 3 moreextracellular space, cytosolOne of 4 routes

• butyric acidReach from here →
  1. transport of acetylcholine (cytosol to extracellular)
  2. Acetylcholine aectylhydrolase
  3. transport of acetate and butyrate (cytosol to extracellular)

  Catalysed by SLCO1B3, BCHE, ACHE, SLC16A4 and 3 moreextracellular space, cytosolOne of 4 routes

• maleateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• malonic acidReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. transport of malonate and sulfate (cytosol to mitochondria)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A10extracellular space, cytosol, mitochondrial matrixOne of 2 routes

• tetradecanoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• (9Z)-octadecenoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 14 routes

• adipic acidReach from here →
  1. solute carrier organic anion transporter (glycocholate)
  2. glycocholate(out) + glutarate(in) = glycocholate(in) + glutarate(out)
  3. hexanedioate + glutaryl-CoA = hexanedioyl-CoA + glutarate

  Catalysed by SLCO1A2, SLCO1B3, SLC22A24, SUGCTextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (indol-3-yl)acetateReach from here →
  1. transport of prostaglandin E2 (cytosol to extracellular)
  2. prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)
  3. (indol-3-yl)acetate(out) + a dicarboxylate(in) = (indol-3-yl)acetate(in) + a dicarboxylate(out)

  Catalysed by SLCO1A2, SLCO1B3, SLC22A6, SLC22A8extracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• an alcoholReach from here →
  1. solute carrier organic anion transporter (cholate)
  2. cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
  3. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O

  Catalysed by SLCO1A2, SLCO1B3, ABCC4, CP and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membrane

• (2R,3R)-tartrateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. (2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (S,S)-tartrateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. (S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3R)-citramalateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. (3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• (3S)-citramalateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. (3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

• hexacosanoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• tetracosanoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• an N-acylsphinganineReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. N-acylsphingosine amidohydrolase

  Catalysed by SLCO1B1, ASAH1, ACER2, ACER1 and 2 moreextracellular space, cytosol

• eicosanoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• (9Z)-hexadecenoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 18 routes

• (15Z)-tetracosenoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• (11Z)-eicosenoateReach from here →
  1. transport of arachidonate (cytosol to extracellular)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by SLCO1B1extracellular space, cytosolOne of 12 routes

• 3-oxopropanoateReach from here →
  1. transport of prostaglandin H2 (cytosol to extracellular)
  2. thromboxane A synthase (12(S)-HHT)
  3. malonaldehyde + NAD(+) + H2O = 3-oxopropanoate + NADH + 2 H(+)

  Catalysed by SLCO1B1, TBXAS1, ALDH1A1, ALDH1B1 and 1 moreextracellular space, cytosol

• thiosulfateReach from here →
  1. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  2. steroid sulfatase (sulfoglycolithocholate)
  3. thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

  Catalysed by SLCO1A2, SLCO1B3, STS, SLC25A14 and 3 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes