leukotriene F4

Three steps

• N-hexadecanoylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

  Catalysed by GLYATL3cytosol

• N-dodecanoylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. dodecanoyl-CoA + glycine = N-dodecanoylglycine + CoA + H(+)

  Catalysed by GLYATL2cytosol

• N-decanoylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. decanoyl-CoA + glycine = N-decanoylglycine + CoA + H(+)

  Catalysed by GLYATL2cytosol

• N-octanoylglycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. octanoyl-CoA + glycine = N-octanoylglycine + CoA + H(+)

  Catalysed by GLYATL2cytosol

• N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

  Catalysed by GARTcytosol

• L-cystine-bis-glycineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. glutathione gamma-glutamylaminopeptidase
  3. 2 L-cysteinylglycine + [protein]-disulfide = L-cystine-bis-glycine + [protein]-dithiol

  Catalysed by GGTLC3, GGT1, GGT5, GGTLC2 and 3 moreextracellular space, cytosolOne of 2 routes

• glycyldehydrophenylalanineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. glycyldehydrophenylalanine + H2O = 2,3-didehydrophenylalanine + glycine

  Catalysed by DPEP1cytosol

• S-adenosylglutathioneReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. apo-[alkylcobalamin reductase] + adenosylcob(III)alamin + glutathione = S-adenosylglutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 1 morecytosol

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by SLCO1B1extracellular space, cytosolOne of 2 routes

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by SLCO1B1, FAAH, PM20D1extracellular space, cytosol

• an N-(fatty acyl)-glycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. a fatty acyl-CoA + glycine = an N-(fatty acyl)-glycine + CoA + H(+)

  Catalysed by GLYATL2cytosol

• N-(9Z,12Z-octadecadienoyl)-glycineReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. (9Z,12Z)-octadecadienoyl-CoA + glycine = N-(9Z,12Z-octadecadienoyl)-glycine + CoA + H(+)

  Catalysed by GLYATL2cytosol

• (7Z)-octadecenoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 3 routes

• (15S)-15-hydroperoxy-prostaglandin E2Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of prostaglandin G2 (cytosol to extracellular)
  3. prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2

  Catalysed by SLCO1B1, PTGESextracellular space, cytosol

• CHEBI:15345Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosolOne of 2 routes

• cholineReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of acetylcholine (cytosol to extracellular)
  3. Acetylcholine aectylhydrolase

  Catalysed by SLCO1B1, SLCO1B3, BCHE, ACHEextracellular space, cytosolOne of 6 routes

• pyruvateReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. L-cysteine hydrogen-sulfide-lyase (deaminating

  Catalysed by CTHextracellular space, cytosolOne of 2 routes

• CHEBI:15380Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosol, mitochondrial matrixOne of 8 routes

• CHEBI:15477Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. glycine N-acyltransferase (2-methylbutyryl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 2 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Production of Tiglylcarnitine

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 2 routes

• isobutyryl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosol, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, SLC27A2, ACSL4, ACSL3 and 5 moreextracellular space, cytosolOne of 14 routes

• CHEBI:15519Reach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (cholate)
  3. Cholate:CoA ligase (AMP-forming)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, SLC27A2 and 1 moreextracellular space, cytosol, endoplasmic reticulumOne of 3 routes

• palmitoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 36 morecytosolOne of 11 routes

• oleoyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 11 routes

• phenylacetyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Phenylacetate:CoA ligase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosolOne of 3 routes

• propionyl-CoAReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Propanoate:CoA ligase (AMP-forming)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 31 morecytosolOne of 43 routes

• CHEBI:15570Reach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. transport of D-alanine and glycine (cytosol to extracellular)

  Catalysed by SLC3A2, SLC7A10cytosol, extracellular spaceOne of 2 routes

• L-leucineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and leucine (cytosol to extracellular)

  Catalysed by SLC7A9, SLC3A1extracellular space, cytosolOne of 8 routes

• CHEBI:15611Reach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 hydrolysis
  3. S-Adenosyl-L-methionine:glycine N-methyltransferase

  Catalysed by GNMTcytosol

• 12(S)-HPETEReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by SLCO1B1, ALOX12extracellular space, cytosolOne of 4 routes

• 15(S)-HPETEReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by SLCO1B1, ALOX15B, ALOX15extracellular space, cytosolOne of 6 routes

• 5(S)-HPETEReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of arachidonate (cytosol to extracellular)
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLCO1B1, ALOX5extracellular space, cytosol

• CHEBI:15699Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and homoserine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 7 routes

• CHEBI:15727Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. N-alpha-acetyltransferase 10, NatA catalytic subunit (acetylcarnosine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 28 morecytosol

• formateReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. alcohol dehydrogenase (formaldehyde)
  3. S-formylglutathione + H2O = formate + glutathione + H(+)

  Catalysed by ADH1C, ADH1A, ADH5, ADH6 and 3 moreextracellular space, cytosol

• CHEBI:15746Reach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 30 morecytosolOne of 2 routes

• CHEBI:15971Reach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and histidine (cytosol to extracellular)

  Catalysed by SLC7A6extracellular space, cytosolOne of 4 routes

• (R)-lactateReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. (R)-S-Lactoylglutathione methylglyoxal-lyase (isomerizing)
  3. (R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

  Catalysed by GLO1, GLOD4, HAGHextracellular space, cytosol

• a halide anionReach from here →
  1. leukotriene C4 hydrolysis
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by MGST3, GSTM4, LTC4S, MGST2 and 21 morecytosol

• octan-1-olReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. solute carrier organic anion transporter (chenodiol)
  3. octyl beta-D-glucose + chenodeoxycholate = beta-D-glucosyl-(1->3)-O-chenodeoxycholate + octan-1-ol

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, GBA2extracellular space, cytosol

• sulfateReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. steroid sulfatase (sulfoglycolithocholate)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, STSextracellular space, cytosolOne of 7 routes

• L-cystineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. Glutathione: 5-HPETE oxidoreductase
  3. cystine to cysteine conversion

  Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 moreextracellular space, cytosolOne of 5 routes

• 11-cis-retinolReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 33 morecytosol

• L-citrullineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of citrulline and cysteine (cytosol to extracellular)

  Catalysed by SLC7A6extracellular space, cytosolOne of 3 routes

• iodideReach from here →
  1. transport of leukotriene F4 (cytosol to extracellular)
  2. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)
  3. 3,3',5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating)

  Catalysed by SLCO1B1, SLCO1A2, SLCO1B3, DIO1 and 1 moreextracellular space, cytosolOne of 9 routes

• L-valineReach from here →
  1. transport of GSH and leukotriene F4 (cytosol to extracellular)
  2. cystine to cysteine conversion
  3. transport of cysteine and valine (cytosol to extracellular)

  Catalysed by SLC7A5extracellular space, cytosolOne of 7 routes

• oxaloacetateReach from here →
  1. leukotriene F4 hydrolysis
  2. N-acetyl-LTE4 to leukotriene E4 conversion
  3. ATP citrate lyase (citrate)

  Catalysed by ZDHHC11B, NAA10, ESCO2, ESCO1 and 29 morecytosol