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Proteins/UNIPROT:P68104
Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1. Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity)..
(Microbial infection) Required for the translation of viral proteins and viral replication during human coronavirus SARS-CoV-2 infection..
Function from UniProtKB (P68104), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
186 statements
186 statements · 4 reference databases · Subject: EEF1A1 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
2 reactions
9 names
Resolves to: EEF1A1
Human-GEM MAR04136CC BY 4.0Reference data
GTP+waterGDP+hydrogenphosphate+hydron
Catalysed by IRGM or RAB19 or TUBAL3 or GTPBP1 or RAB27B or RHOD or DNM1L or MRAS or RAB29 or OPA1 or EIF5B or ENTPD3 and 183 more alternatives
Reaction pageLeft to rightBalanced
Rhea RHEA:19669CC BY 4.0Reference data