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Proteins/UNIPROT:P10070
Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in skeleton development. Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA-3' to activate or repress the expression of target genes (By similarity). Functions both as a transcriptional activator and repressor: the full-length GLI2 form (Transcription activator GLI2) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI2R, which is generated in absence of smoothened, acts as a transcription repressor (By similarity). The transcriptional activator form constitutes the major form of GLI2 (By similarity)..
[Transcription activator GLI2]: Transcription factor, which activates expression of target genes in response to smoothened (SMO) activation. Constitutes a major form of GLI2, while the transcription repressor form (GLI2R) plays a minor role (By similarity)..
[Transcription repressor GLI2R]: Transcription repressor, which inhibits expression of target genes in the absence of smoothened (SMO) signaling (By similarity). Generated by proteolytic processing of the full-length GLI2 form in the absence of hedgehog (DHH, IHH or SHH), when SMO transducer is inhibited (By similarity). Constitutes a minor form of GLI2, while the transcription activator GLI2 form plays a major role in smoothened signaling (By similarity)..
[Isoform 1]: Involved in the smoothened (SHH) signaling pathway..
[Isoform 2]: Involved in the smoothened (SHH) signaling pathway..
[Isoform 3]: Involved in the smoothened (SHH) signaling pathway..
[Isoform 4]: Involved in the smoothened (SHH) signaling pathway..
[Isoform 5]: Acts as a transcriptional repressor..
[Isoform 1]: (Microbial infection) Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1..
[Isoform 2]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1..
[Isoform 3]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1..
[Isoform 4]: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1..
Function from UniProtKB (P10070), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
263 statements
263 statements · 4 reference databases · Subject: GLI2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways
4 names
Resolves to: GLI2