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Proteins/UNIPROT:Q8WW35

DYNLT2B

Protein·UNIPROT:Q8WW35

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Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. Required for proper retrograde ciliary transport..

Function from UniProtKB (Q8WW35), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

short-rib thoracic dysplasia 17 with or without polydactyly has a germline basis in DYNLT2BDiseaseGenCC HGNC:28482|MONDO:0054565Inferred only

Statements

16 statements

16 statements · 4 reference databases · Subject: DYNLT2B · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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CSNK2B interacts with DYNLT2BProteinHetionet hetionet:interacts:1460-255758Inferred only
GTF2F2 interacts with DYNLT2BProteinHetionet hetionet:interacts:255758-2963Inferred only
PPP2CB interacts with DYNLT2BProteinHetionet hetionet:interacts:255758-5516Inferred only
TK1 interacts with DYNLT2BProteinHetionet hetionet:interacts:255758-7083Inferred only
DYNLT2B participates in 3q29 copy number variation syndromePathwayWikiPathways WP4906Inferred only
DYNLT2B participates in Assembly of the 9+0 primary ciliumPathwayReactome R-HSA-9975921Inferred only
DYNLT2B participates in Bardet Biedl syndromePathwayWikiPathways WP5234Inferred only
DYNLT2B participates in Ciliary landscapePathwayWikiPathways WP4352Inferred only
DYNLT2B participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
DYNLT2B participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
DYNLT2B participates in Genes related to primary cilium development based on CRISPR PathwayWikiPathways WP4536Inferred only
DYNLT2B participates in Intraflagellar transportPathwayReactome R-HSA-5620924Inferred only

Show the remaining 4

DYNLT2B participates in Intraflagellar transport proteins binding to dyneinPathwayWikiPathways WP4532Inferred only
DYNLT2B participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
DYNLT2B regulates regulation of cilium assemblyBiological processgene ontology Q8WW35|GO:1902017Inferred only
DYNLT2B regulates regulation of intraciliary retrograde transportBiological processgene ontology Q8WW35|GO:1905799Inferred only

Other names

3 names

Resolves to: DYNLT2B

Also called: Dynein light chain Tctex-type protein 2BTctex1 domain-containing protein 2TCTEX1D2

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