Loading the page.
Proteins/UNIPROT:Q86XA0
Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity)..
Function from UniProtKB (Q86XA0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
16 statements
16 statements · 4 reference databases · Subject: METTL23 · Sources: Bgee, gene ontology, Hetionet, Reactome
1 reaction
L-arginyl-[protein]+2S-adenosyl-L-methionineN(omega),N(omega)-dimethyl-L-arginyl-[protein]+2S-adenosyl-L-homocysteine+2hydron
Catalysed by PRMT3 or PRMT2 or CARM1 or METTL23 or PRMT6 or PRMT1 or PRMT8
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:48096CC BY 4.0Reference data
2 names
Resolves to: METTL23