Proteins/UNIPROT:Q9Y5U9

IER3IP1

ProteinUNIPROT:Q9Y5U9

Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors. Acts as a regulator of the unfolded protein response (UPR) (By similarity)..

Function from UniProtKB (Q9Y5U9), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

microcephaly, epilepsy, and diabetes syndrome 1 has a germline basis in IER3IP1DiseaseGenCC HGNC:18550|MONDO:0031481Inferred only

Statements

16 statements

16 statements · 2 reference databases · Subject: IER3IP1 · Sources: gene ontology, Hetionet

Order

BHLHE22 covaries with IER3IP1ProteinHetionet hetionet:covaries:27319-51124Inferred only
IFNA7 covaries with IER3IP1ProteinHetionet hetionet:covaries:3444-51124Inferred only
IER3IP1 interacts with ANKRD34AProteinHetionet hetionet:interacts:284615-51124Inferred only
CSNK2B interacts with IER3IP1ProteinHetionet hetionet:interacts:1460-51124Inferred only
RGS2 interacts with IER3IP1ProteinHetionet hetionet:interacts:51124-5997Inferred only
TK1 interacts with IER3IP1ProteinHetionet hetionet:interacts:51124-7083Inferred only
TRAF6 interacts with IER3IP1ProteinHetionet hetionet:interacts:51124-7189Inferred only
UBC interacts with IER3IP1ProteinHetionet hetionet:interacts:51124-7316Inferred only
IER3IP1 regulates positive regulation of extracellular matrix constituent secretionBiological processgene ontology Q9Y5U9|GO:0003331Inferred only
IER3IP1 regulates positive regulation of protein secretionBiological processgene ontology Q9Y5U9|GO:0050714Inferred only
IER3IP1 regulates regulation of fibroblast apoptotic processBiological processgene ontology Q9Y5U9|GO:2000269Inferred only
CTRB1 increases the expression of IER3IP1ProteinHetionet hetionet:regulates:1504-51124Inferred only

Show the remaining 4

GNAS increases the expression of IER3IP1ProteinHetionet hetionet:regulates:2778-51124Inferred only
NIPSNAP1 increases the expression of IER3IP1ProteinHetionet hetionet:regulates:8508-51124Inferred only
PCMT1 decreases the expression of IER3IP1ProteinHetionet hetionet:regulates:5110-51124Inferred only
PIN1 increases the expression of IER3IP1ProteinHetionet hetionet:regulates:5300-51124Inferred only

Other names

1 name

Resolves to: IER3IP1

Also called: Immediate early response 3-interacting protein 1

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