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© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:Q12840

KIF5A

Protein·UNIPROT:Q12840

Open in the graph

Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner. The ZFYVE27-KIF5A complex contributes to the vesicular transport of VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 proteins in neurons. Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation..

Function from UniProtKB (Q12840), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

5 rows

amyotrophic lateral sclerosis, susceptibility to, 25 has a germline basis in KIF5ADiseaseGenCC HGNC:6323|MONDO:0060670Inferred only
autosomal dominant Charcot-Marie-Tooth disease type 2 due to KIF5A mutation has a germline basis in KIF5ADiseaseGenCC HGNC:6323|MONDO:0017940Inferred only
hereditary spastic paraplegia 10 has a germline basis in KIF5ADiseaseGenCC HGNC:6323|MONDO:0011408Inferred only
inherited neurodegenerative disorder has a germline basis in KIF5ADiseaseGenCC HGNC:6323|MONDO:0024237Inferred only
myoclonus, intractable, neonatal has a germline basis in KIF5ADiseaseGenCC HGNC:6323|MONDO:0014979Inferred only

Statements

47 statements

47 statements · 3 reference databases · Subject: KIF5A · Sources: Hetionet, Reactome, WikiPathways

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CA7 covaries with KIF5AProteinHetionet hetionet:covaries:3798-766Inferred only
KIF5A interacts with ANKRD27ProteinHetionet hetionet:interacts:3798-84079Inferred only
DTNB interacts with KIF5AProteinHetionet hetionet:interacts:1838-3798Inferred only
KIF5A interacts with EXOC1ProteinHetionet hetionet:interacts:3798-55763Inferred only
KIF5A interacts with IFT54ProteinHetionet hetionet:interacts:26146-3798Inferred only
KIF5A interacts with ITSN1ProteinHetionet hetionet:interacts:3798-6453Inferred only
KIF5A interacts with KCNE3ProteinHetionet hetionet:interacts:10008-3798Inferred only
KIF5A interacts with KIF5BProteinHetionet hetionet:interacts:3798-3799Inferred only
KIF5A interacts with MAP4K4ProteinHetionet hetionet:interacts:3798-9448Inferred only
KIF5A interacts with NCOA2ProteinHetionet hetionet:interacts:10499-3798Inferred only
KIF5A interacts with PCBD1ProteinHetionet hetionet:interacts:3798-5092Inferred only
KIF5A interacts with PIN1ProteinHetionet hetionet:interacts:3798-5300Inferred only

Show the remaining 35

KIF5A interacts with RAPGEF2ProteinHetionet hetionet:interacts:3798-9693Inferred only
KIF5A interacts with RXRBProteinHetionet hetionet:interacts:3798-6257Inferred only
KIF5A interacts with SMN1; SMN2ProteinHetionet hetionet:interacts:3798-6607Inferred only
KIF5A interacts with SMN1; SMN2ProteinHetionet hetionet:interacts:3798-6606Inferred only
KIF5A interacts with TK1ProteinHetionet hetionet:interacts:3798-7083Inferred only
KIF5A interacts with TP53BP2ProteinHetionet hetionet:interacts:3798-7159Inferred only
KIF5A interacts with TSG101ProteinHetionet hetionet:interacts:3798-7251Inferred only
KIF5A interacts with UBCProteinHetionet hetionet:interacts:3798-7316Inferred only
KIF5A interacts with YAP1ProteinHetionet hetionet:interacts:10413-3798Inferred only
KIF5A participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
KIF5A participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
KIF5A participates in Alzheimer 39 s diseasePathwayWikiPathways WP5124Inferred only
KIF5A participates in Alzheimer 39 s disease and miRNA effectsPathwayWikiPathways WP2059Inferred only
KIF5A participates in COPI-dependent Golgi-to-ER retrograde trafficPathwayReactome R-HSA-6811434Inferred only
KIF5A participates in Effect of omega 3 PUFA on Huntington 39 s disease pathwaysPathwayWikiPathways WP5470Inferred only
KIF5A participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
KIF5A participates in Golgi-to-ER retrograde transportPathwayReactome R-HSA-8856688Inferred only
KIF5A participates in HemostasisPathwayReactome R-HSA-109582Inferred only
KIF5A participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
KIF5A participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
KIF5A participates in Insulin processingPathwayReactome R-HSA-264876Inferred only
KIF5A participates in Intra-Golgi and retrograde Golgi-to-ER trafficPathwayReactome R-HSA-6811442Inferred only
KIF5A participates in KinesinsPathwayReactome R-HSA-983189Inferred only
KIF5A participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
KIF5A participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
KIF5A participates in MHC class II antigen presentationPathwayReactome R-HSA-2132295Inferred only
KIF5A participates in Non small cell lung cancerPathwayWikiPathways WP4255Inferred only
KIF5A participates in Peptide hormone metabolismPathwayReactome R-HSA-2980736Inferred only
KIF5A participates in Processing of antigen in germinal center B cellsPathwayReactome R-HSA-9979719Inferred only
KIF5A participates in RHO GTPase EffectorsPathwayReactome R-HSA-195258Inferred only
KIF5A participates in RHO GTPases activate KTN1PathwayReactome R-HSA-5625970Inferred only
KIF5A participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
KIF5A participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
KIF5A participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
KIF5A participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only

Other names

4 names

Resolves to: KIF5A

Also called: Kinesin heavy chain neuron-specific 1Neuronal kinesin heavy chainNKHCNKHC1

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