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Proteins/UNIPROT:Q96N67

DOCK7

Protein·UNIPROT:Q96N67

Open in the graph

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. As part of the DISP complex, may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. Has a role in pigmentation (By similarity). Involved in the regulation of cortical neurogenesis through the control of radial glial cells (RGCs) proliferation versus differentiation; negatively regulates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtubule growth-promoting function of TACC3 (By similarity)..

Function from UniProtKB (Q96N67), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

developmental and epileptic encephalopathy, 23 has a germline basis in DOCK7DiseaseGenCC HGNC:19190|MONDO:0014371Inferred only
genetic developmental and epileptic encephalopathy has a germline basis in DOCK7DiseaseGenCC HGNC:19190|MONDO:0100062Inferred only

Statements

34 statements

34 statements · 4 reference databases · Subject: DOCK7 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Search this listOrder

SBK3 covaries with DOCK7ProteinHetionet hetionet:covaries:100130827-85440Inferred only
ANXA7 interacts with DOCK7ProteinHetionet hetionet:interacts:310-85440Inferred only
BCL2L1 interacts with DOCK7ProteinHetionet hetionet:interacts:598-85440Inferred only
CDC42 interacts with DOCK7ProteinHetionet hetionet:interacts:85440-998Inferred only
CDKN1A interacts with DOCK7ProteinHetionet hetionet:interacts:1026-85440Inferred only
PPP2CB interacts with DOCK7ProteinHetionet hetionet:interacts:5516-85440Inferred only
RHOA interacts with DOCK7ProteinHetionet hetionet:interacts:387-85440Inferred only
RPP14 interacts with DOCK7ProteinHetionet hetionet:interacts:11102-85440Inferred only
SIRT7 interacts with DOCK7ProteinHetionet hetionet:interacts:51547-85440Inferred only
SMN1; SMN2 interacts with DOCK7ProteinHetionet hetionet:interacts:6607-85440Inferred only
SMN1; SMN2 interacts with DOCK7ProteinHetionet hetionet:interacts:6606-85440Inferred only
SNCA interacts with DOCK7ProteinHetionet hetionet:interacts:6622-85440Inferred only

Show the remaining 22

TK1 interacts with DOCK7ProteinHetionet hetionet:interacts:7083-85440Inferred only
UBC interacts with DOCK7ProteinHetionet hetionet:interacts:7316-85440Inferred only
VCP interacts with DOCK7ProteinHetionet hetionet:interacts:7415-85440Inferred only
DOCK7 participates in BDNF signaling in neurodevelopmentPathwayWikiPathways WP5541Inferred only
DOCK7 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
DOCK7 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only
DOCK7 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
DOCK7 participates in MET activates RAP1 and RAC1PathwayReactome R-HSA-8875555Inferred only
DOCK7 participates in MET promotes cell motilityPathwayReactome R-HSA-8875878Inferred only
DOCK7 participates in miR targeted genes in lymphocytesPathwayWikiPathways WP2004Inferred only
DOCK7 participates in miR targeted genes in muscle cellPathwayWikiPathways WP2005Inferred only
DOCK7 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
DOCK7 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
DOCK7 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DOCK7 participates in Signaling by METPathwayReactome R-HSA-6806834Inferred only
DOCK7 participates in Signaling by Receptor Tyrosine KinasesPathwayReactome R-HSA-9006934Inferred only
DOCK7 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
DOCK7 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
DOCK7 regulates negative regulation of cold-induced thermogenesisBiological processgene ontology Q96N67|GO:0120163Inferred only
DOCK7 regulates positive regulation of vascular associated smooth muscle cell migrationBiological processgene ontology Q96N67|GO:1904754Inferred only
DOCK7 regulates regulation of neurogenesisBiological processgene ontology Q96N67|GO:0050767Inferred only
DOCK7 regulates regulation of Rho protein signal transductionBiological processgene ontology Q96N67|GO:0035023Inferred only

Other names

2 names

Resolves to: DOCK7

Also called: Dedicator of cytokinesis protein 7KIAA1771

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