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Proteins/UNIPROT:Q9BT40
Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (By similarity)..
Function from UniProtKB (Q9BT40), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
53 statements
53 statements · 7 reference databases · Subject: INPP5K · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
7 reactions
1D-myo-inositol 1,4,5-trisphosphate+waterMAM00526c+phosphate(3-)
Catalysed by INPP5A or INPP5K or INPP5J
Reaction pageLeft to rightBalancedEC 3.1.3.56cytosol
Human-GEM MAR06560CC BY 4.0Reference data
MAM00522c+waterMAM00524c+phosphate(3-)
5 names
Resolves to: INPP5K
Reaction pageLeft to rightBalancedEC 3.1.3.56, 3.1.3.86cytosol
Human-GEM MAR06565CC BY 4.0Reference data
CHEBI:57895+waterCHEBI:58414+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or OCRL or INPP5A or INPP5J or INPP5D or INPP5K
Reaction pageLeft to rightBalanced
Rhea RHEA:11392CC BY 4.0Reference data
1D-myo-inositol 1,4,5-trisphosphate+waterCHEBI:58282+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5A or INPP5J or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalanced
Rhea RHEA:19797CC BY 4.0Reference data
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)+watera 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)+hydrogenphosphate
Catalysed by SYNJ2 or SYNJ1 or INPP5B or OCRL or INPP5J or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:22764CC BY 4.0Reference data
CHEBI:57836+waterCHEBI:57658+hydrogenphosphate
Catalysed by SYNJ2 or INPPL1 or SYNJ1 or OCRL or FIG4 or INPP5D or INPP5K or INPP5E
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:25528CC BY 4.0Reference data
CHEBI:83416+waterCHEBI:83417+hydrogenphosphate
Catalysed by INPPL1 or SYNJ1 or INPP5K
Reaction pageReversibleBalanced
Rhea RHEA:43548CC BY 4.0Reference data