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Proteins/UNIPROT:P00488
Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin..
Function from UniProtKB (P00488), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
29 statements
29 statements · 4 reference databases · Subject: F13A1 · Sources: Hetionet, Reactome, UniProt, WikiPathways
2 reactions
MAM00201c+MAM01310cMAM00207c+ammonium
Catalysed by TGM1 or TGM5 or F13A1 or TGM3 or F13B or TGM7 or TGM6 or TGM2
Reaction pageLeft to rightBalance undeterminableEC 2.3.2.13cytosol
Human-GEM MAR09496CC BY 4.0Reference data
L-glutaminyl-[protein]+L-lysyl-[protein][protein]-L-lysyl-N(6)-5-L-glutamyl-[protein]
4 names
Resolves to: F13A1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:54816CC BY 4.0Reference data