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Proteins/UNIPROT:Q9NX74
Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U20 in cytoplasmic tRNAs. Activity depends on the presence of guanosine at position 19 in the tRNA substrate. Negatively regulates the activation of EIF2AK2/PKR..
Function from UniProtKB (Q9NX74), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
23 statements
23 statements · 3 reference databases · Subject: DUS2 · Sources: Hetionet, Reactome, UniProt
1 reaction
CHEBI:74443+NADP(3-)CHEBI:65315+NADPH(4-)+hydron
Catalysed by DUS2
Reaction pageRight to leftBalanced
Rhea RHEA:53336CC BY 4.0Reference data
8 names
Resolves to: DUS2