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Proteins/UNIPROT:O00142
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents..
Function from UniProtKB (O00142), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
21 statements
21 statements · 5 reference databases · Subject: TK2 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
Catalysed by TK2
Reaction pageLeft to rightBalancedEC 2.7.1.21mitochondrial matrix
Human-GEM MAR04483CC BY 4.0Reference data
2'-deoxyuridine+CHEBI:16497CHEBI:28862+dUMP+proton
Catalysed by TK2
3 names
Resolves to: TK2
Human-GEM MAR06624CC BY 4.0Reference data
ATP+2'-deoxyuridineADP+dUMP+proton
Catalysed by TK2
Reaction pageLeft to rightBalancedEC 2.7.1.21mitochondrial matrix
Human-GEM MAR06625CC BY 4.0Reference data
thymidine+ATP(4-)dTMP+ADP(3-)+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:19129CC BY 4.0Reference data
2'-deoxyuridine+ATP(4-)dUMP+ADP(3-)+hydron
Catalysed by TK2
Reaction pageLeft to rightBalanced
Rhea RHEA:28206CC BY 4.0Reference data
2'-deoxycytidine+ATP(4-)dCMP+ADP(3-)+hydron
Catalysed by TK2
Reaction pageLeft to rightBalanced
Rhea RHEA:46040CC BY 4.0Reference data