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Proteins/UNIPROT:Q9BY66
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks..
Function from UniProtKB (Q9BY66), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
38 statements
38 statements · 5 reference databases · Subject: KDM5D · Sources: gene ontology, Hetionet, Reactome, Rhea, UniProt
1 reaction
N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3]+32-oxoglutarate(2-)+3dioxygenL-lysyl(4)-[histone H3]+3formaldehyde+3succinate(2-)+3carbon dioxide
Catalysed by KDM5A or KDM5C or KDM5D or KDM5B
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:60208CC BY 4.0Reference data
11 names
Resolves to: KDM5D