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Proteins/UNIPROT:Q9NQ38

SPINK5

Protein·UNIPROT:Q9NQ38

Open in the graph

Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, its major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin..

Function from UniProtKB (Q9NQ38), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

Netherton syndrome has a germline basis in SPINK5DiseaseGenCC HGNC:15464|MONDO:0009735Inferred only

Statements

19 statements

19 statements · 4 reference databases · Subject: SPINK5 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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SPINK5 covaries with KRTDAPProteinHetionet hetionet:covaries:11005-388533Inferred only
SPINK5 interacts with KLK14ProteinHetionet hetionet:interacts:11005-43847Inferred only
KLK7 interacts with SPINK5ProteinHetionet hetionet:interacts:11005-5650Inferred only
PRSS1 interacts with SPINK5ProteinHetionet hetionet:interacts:11005-5644Inferred only
SPINK5 participates in Developmental BiologyPathwayReactome R-HSA-1266738Inferred only
SPINK5 participates in Developmental Cell LineagesPathwayReactome R-HSA-9734767Inferred only
SPINK5 participates in Developmental Cell Lineages of the Integumentary SystemPathwayReactome R-HSA-9734779Inferred only
SPINK5 participates in Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian SkinPathwayReactome R-HSA-9725554Inferred only
SPINK5 participates in Formation of the cornified envelopePathwayReactome R-HSA-6809371Inferred only
SPINK5 participates in Hair follicle development cytodifferentiation stage 3 of 3PathwayWikiPathways WP2840Inferred only
SPINK5 participates in KeratinizationPathwayReactome R-HSA-6805567Inferred only
SPINK5 regulates negative regulation of angiogenesisBiological processgene ontology Q9NQ38|GO:0016525Inferred only

Show the remaining 7

SPINK5 regulates negative regulation of antibacterial peptide biosynthetic processBiological processgene ontology Q9NQ38|GO:0002809Inferred only
SPINK5 regulates negative regulation of immune responseBiological processgene ontology Q9NQ38|GO:0050777Inferred only
SPINK5 regulates regulation of T cell differentiationBiological processgene ontology Q9NQ38|GO:0045580Inferred only
SPINK5 regulates regulation of timing of anagenBiological processgene ontology Q9NQ38|GO:0051884Inferred only
CLTB decreases the expression of SPINK5ProteinHetionet hetionet:regulates:1212-11005Inferred only
GNA11 increases the expression of SPINK5ProteinHetionet hetionet:regulates:2767-11005Inferred only
SLC16A3 increases the expression of SPINK5ProteinHetionet hetionet:regulates:9123-11005Inferred only

Other names

3 names

Resolves to: SPINK5

Also called: [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]LEKTILympho-epithelial Kazal-type-related inhibitor

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