Proteins/UNIPROT:Q99439

CNN2

ProteinUNIPROT:Q99439

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

Function from UniProtKB (Q99439), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

28 statements

28 statements · 4 reference databases · Subject: CNN2 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ACTB interacts with CNN2ProteinHetionet hetionet:interacts:1265-60Inferred only
CNN2 interacts with LAGE3ProteinHetionet hetionet:interacts:1265-8270Inferred only
CNN2 interacts with MAT2BProteinHetionet hetionet:interacts:1265-27430Inferred only
CNN2 interacts with UBCProteinHetionet hetionet:interacts:1265-7316Inferred only
CNN2 participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
CNN2 participates in Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationPathwayReactome R-HSA-8950505Inferred only
CNN2 participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
CNN2 participates in Innate Immune SystemPathwayReactome R-HSA-168249Inferred only
CNN2 participates in Interleukin-12 family signalingPathwayReactome R-HSA-447115Inferred only
CNN2 participates in Interleukin-12 signalingPathwayReactome R-HSA-9020591Inferred only
CNN2 participates in Myometrial relaxation and contraction pathwaysPathwayWikiPathways WP289Inferred only
CNN2 participates in Neutrophil degranulationPathwayReactome R-HSA-6798695Inferred only

Show the remaining 16

CNN2 participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
CNN2 regulates regulation of actin filament-based processBiological processgene ontology Q99439|GO:0032970Inferred only
ATP6V1D decreases the expression of CNN2ProteinHetionet hetionet:regulates:51382-1265Inferred only
CREBL2 decreases the expression of CNN2ProteinHetionet hetionet:regulates:1389-1265Inferred only
CYP51A1 decreases the expression of CNN2ProteinHetionet hetionet:regulates:1595-1265Inferred only
EPS8 decreases the expression of CNN2ProteinHetionet hetionet:regulates:2059-1265Inferred only
GRN decreases the expression of CNN2ProteinHetionet hetionet:regulates:2896-1265Inferred only
HOXA5 decreases the expression of CNN2ProteinHetionet hetionet:regulates:3202-1265Inferred only
NR4A2 decreases the expression of CNN2ProteinHetionet hetionet:regulates:4929-1265Inferred only
NRBP2 decreases the expression of CNN2ProteinHetionet hetionet:regulates:340371-1265Inferred only
PIAS2 decreases the expression of CNN2ProteinHetionet hetionet:regulates:9063-1265Inferred only
PPP3CA decreases the expression of CNN2ProteinHetionet hetionet:regulates:5530-1265Inferred only
RBL2 decreases the expression of CNN2ProteinHetionet hetionet:regulates:5934-1265Inferred only
SLC16A3 decreases the expression of CNN2ProteinHetionet hetionet:regulates:9123-1265Inferred only
TNFRSF21 increases the expression of CNN2ProteinHetionet hetionet:regulates:27242-1265Inferred only
VCAN decreases the expression of CNN2ProteinHetionet hetionet:regulates:1462-1265Inferred only

Other names

2 names

Resolves to: CNN2

Also called: Calponin H2, smooth muscleNeutral calponin

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