Pathway
Cell surface interactions at the vascular wall
Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates.
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Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established.
This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury.
REACT:R-HSA-202733Reactome
What the reference databases state
Statements
130 statements
130 statements · 1 reference database · Subject: Cell surface interactions at the vascular wall · Sources: Reactome
- ANGPT1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ANGPT2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ANGPT4 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- APOB participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ATP1B1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ATP1B2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ATP1B3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- BSG participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CAV1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD177 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD244 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
Show the remaining 118
- CD44 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD47 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD48 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD58 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD74 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD84 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD99 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CD99L2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CEACAM1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CEACAM3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CEACAM5 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CEACAM6 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CEACAM8 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- COL1A1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- COL1A2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- CXADR participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- DOK2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- EPCAM participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- F11R participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- F2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- FCAMR participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- FCER1G participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- FN1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- FYN participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GAS6 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GLG1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GP6 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GPC1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GRB14 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GRB7 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GYPA participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GYPB participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- GYPC participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- HRAS participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- IGLL1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- INPP5D participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGA3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGA4 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGA5 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGA6 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGAL participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGAM participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGAV participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGAX participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGB1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGB2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- ITGB3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- JAM2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- JAM3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- JAML participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- JCHAIN participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- L1CAM participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- LCK participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- LYN participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- MAG participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- MERTK participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- MIF participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- MMP1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- NRAS participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- OLR1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PECAM1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PF4 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PF4V1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PICK1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PIK3CA participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PIK3CB participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PIK3R1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PIK3R2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PLCG1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PPIA participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PPIL2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PROC participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PROCR participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PROS1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PSG1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PSG11 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PSG2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PSG3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PSG4 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PSG5 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PSG9 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PTPN11 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- PTPN6 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SDC1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SDC2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SDC3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SDC4 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SELE participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SELL participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SELP participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SELPLG participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SHC1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SIRPA participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SIRPG participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC16A1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC16A3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC16A8 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC3A2 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC7A10 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC7A11 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC7A5 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC7A6 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC7A7 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC7A8 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SLC7A9 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SOS1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- SPN participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- TEK participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- TGFB1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- THBD participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- TNFRSF10A participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- TNFRSF10B participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- TNFRSF10D participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- TREM1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- TSPAN7 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- VPREB1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- VPREB3 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only
- YES1 participates in Cell surface interactions at the vascular wallProteinReactome R-HSA-202733Inferred only