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Proteins/UNIPROT:P18615
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA..
(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II..
Function from UniProtKB (P18615), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
137 statements
137 statements · 4 reference databases · Subject: NELFE · Sources: gene ontology, Hetionet, Reactome, WikiPathways
4 names
Resolves to: NELFE