Pathway
Heme degradation
Most of the heme degraded in humans comes from hemoglobin. Approximately 6-8 grams of hemoglobin is degraded daily which is equivalent to approximately 300 milligrams of heme per day. Heme is not recycled so it must be degraded and excreted. The iron, however, is conserved. There are two steps to heme degradation;
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1. cleavage of the heme ring by a microsomal heme oxygenase producing biliverdin
2. biliverdin is reduced to bilirubin.
Bilirubin can then be conjugated with glucuronic acid and excreted.
REACT:R-HSA-189483Reactome
What the reference databases state
Statements
14 statements
14 statements · 1 reference database · Subject: Heme degradation · Sources: Reactome
- ABCC1 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- ABCC2 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- ABCG2 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- ALB participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- BLVRA participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- BLVRB participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- FABP1 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- GSTA1 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- HMOX1 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- HMOX2 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- SLCO1B1 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- SLCO1B3 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
Show the remaining 2
- UGT1A1 participates in Heme degradationProteinReactome R-HSA-189483Inferred only
- UGT1A4 participates in Heme degradationProteinReactome R-HSA-189483Inferred only