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Proteins/UNIPROT:P50579
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo.
Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis.
Function from UniProtKB (P50579), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
87 statements
87 statements · 5 reference databases · Subject: METAP2 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways
7 names
Resolves to: METAP2