Proteins/UNIPROT:Q9UNA1

ARHGAP26

ProteinUNIPROT:Q9UNA1

GTPase-activating protein for RHOA and CDC42. Facilitates mitochondrial quality control by promoting Parkin-mediated recruitment of autophagosomes to damaged mitochondria. Negatively regulates the growth of human parainfluenza virus type 2 by inhibiting hPIV-2-mediated RHOA activation via interaction with two of its viral proteins P and V..

[Isoform 2]: Associates with MICAL1 on the endosomal membrane to promote Rab8-Rab10-dependent tubule extension. After dissociation of MICAL1, recruits WDR44 which connects the endoplasmic reticulum (ER) with the endosomal tubule, thereby participating in the export of a subset of neosynthesized proteins..

Function from UniProtKB (Q9UNA1), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

25 statements

25 statements · 3 reference databases · Subject: ARHGAP26 · Sources: gene ontology, Hetionet, Reactome

Order

CDC42 interacts with ARHGAP26ProteinHetionet hetionet:interacts:23092-998Inferred only
INSR interacts with ARHGAP26ProteinHetionet hetionet:interacts:23092-3643Inferred only
PKN1 interacts with ARHGAP26ProteinHetionet hetionet:interacts:23092-5585Inferred only
ARHGAP26 interacts with PKN3ProteinHetionet hetionet:interacts:23092-29941Inferred only
PTK2 interacts with ARHGAP26ProteinHetionet hetionet:interacts:23092-5747Inferred only
RHOA interacts with ARHGAP26ProteinHetionet hetionet:interacts:23092-387Inferred only
SRPK1 interacts with ARHGAP26ProteinHetionet hetionet:interacts:23092-6732Inferred only
UBC interacts with ARHGAP26ProteinHetionet hetionet:interacts:23092-7316Inferred only
ARHGAP26 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
ARHGAP26 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
ARHGAP26 participates in RAC2 GTPase cyclePathwayReactome R-HSA-9013404Inferred only
ARHGAP26 participates in RAC3 GTPase cyclePathwayReactome R-HSA-9013423Inferred only

Show the remaining 13

ARHGAP26 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
ARHGAP26 participates in RHOA GTPase cyclePathwayReactome R-HSA-8980692Inferred only
ARHGAP26 participates in RHOB GTPase cyclePathwayReactome R-HSA-9013026Inferred only
ARHGAP26 participates in RHOC GTPase cyclePathwayReactome R-HSA-9013106Inferred only
ARHGAP26 participates in RHOD GTPase cyclePathwayReactome R-HSA-9013405Inferred only
ARHGAP26 participates in RHOJ GTPase cyclePathwayReactome R-HSA-9013409Inferred only
ARHGAP26 participates in RHOQ GTPase cyclePathwayReactome R-HSA-9013406Inferred only
ARHGAP26 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
ARHGAP26 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
ARHGAP26 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
ARHGAP26 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q9UNA1|GO:0051056Inferred only
BLVRA increases the expression of ARHGAP26ProteinHetionet hetionet:regulates:644-23092Inferred only
UVRAG increases the expression of ARHGAP26ProteinHetionet hetionet:regulates:7405-23092Inferred only

Other names

7 names

Resolves to: ARHGAP26

Also called: GRAFGRAF1GTPase regulator associated with focal adhesion kinaseKIAA0621Oligophrenin-1-like proteinOPHN1LRho-type GTPase-activating protein 26

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