Proteins/UNIPROT:P22674

CCNO

ProteinUNIPROT:P22674

Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking..

Function from UniProtKB (P22674), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

2 rows

primary ciliary dyskinesia has a germline basis in CCNODiseaseGenCC HGNC:18576|MONDO:0016575Inferred only
primary ciliary dyskinesia 29 has a germline basis in CCNODiseaseGenCC HGNC:18576|MONDO:0014378Inferred only

Statements

17 statements

17 statements · 3 reference databases · Subject: CCNO · Sources: Hetionet, Reactome, WikiPathways

Order

CCNO covaries with BACH1ProteinHetionet hetionet:covaries:10309-571Inferred only
CCNO covaries with KMT2AProteinHetionet hetionet:covaries:10309-4297Inferred only
CCNO covaries with NDNProteinHetionet hetionet:covaries:10309-4692Inferred only
CCNO covaries with PNRC2ProteinHetionet hetionet:covaries:10309-55629Inferred only
CCNO covaries with S100PProteinHetionet hetionet:covaries:10309-6286Inferred only
SMC5 covaries with CCNOProteinHetionet hetionet:covaries:10309-23137Inferred only
DDB1 interacts with CCNOProteinHetionet hetionet:interacts:10309-1642Inferred only
ITSN1 interacts with CCNOProteinHetionet hetionet:interacts:10309-6453Inferred only
PCNA interacts with CCNOProteinHetionet hetionet:interacts:10309-5111Inferred only
RPA2 interacts with CCNOProteinHetionet hetionet:interacts:10309-6118Inferred only
VAV2 interacts with CCNOProteinHetionet hetionet:interacts:10309-7410Inferred only
CCNO participates in Assembly of the 9+2 motile ciliaPathwayReactome R-HSA-9975924Inferred only

Show the remaining 5

CCNO participates in CiliopathiesPathwayWikiPathways WP4803Inferred only
CCNO participates in Cilium AssemblyPathwayReactome R-HSA-5617833Inferred only
CCNO participates in Organelle biogenesis and maintenancePathwayReactome R-HSA-1852241Inferred only
CCNO participates in Transcriptional regulation of multiciliogenesisPathwayReactome R-HSA-9945556Inferred only
BLVRA increases the expression of CCNOProteinHetionet hetionet:regulates:644-10309Inferred only

Other names

1 name

Resolves to: CCNO

Also called: Cyclin-O

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