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Proteins/UNIPROT:Q9NQR1
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration..
Function from UniProtKB (Q9NQR1), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
82 statements
82 statements · 5 reference databases · Subject: KMT5A · Sources: Bgee, gene ontology, Hetionet, Reactome, WikiPathways
9 reactions
12 names
Resolves to: KMT5A
Reaction pageReversibleBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR04241CC BY 4.0Reference data
MAM00204c+S-adenosyl-L-methionineMAM00213c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06975CC BY 4.0Reference data
MAM00213c+S-adenosyl-L-methionineMAM00212c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06976CC BY 4.0Reference data
MAM00212c+S-adenosyl-L-methionineMAM00211c+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C or SETDB2 or SETD1B and 11 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354cytosol
Human-GEM MAR06977CC BY 4.0Reference data
MAM00204n+S-adenosyl-L-methionineproton+MAM02129n+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08025CC BY 4.0Reference data
MAM02129n+S-adenosyl-L-methionineMAM00212n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08026CC BY 4.0Reference data
MAM00212n+S-adenosyl-L-methionineMAM00211n+proton+CHEBI:16680
Catalysed by KMT2C & KMT2B or KMT2D & KMT2C or SETD1A or SUV39H1 or DOT1L or EZH2 or EZH1 or NSD2 or KMT5B or ASH1L or KMT2A or KMT5C and 12 more alternatives
Reaction pageLeft to rightBalance undeterminableEC 2.1.1.354nucleus
Human-GEM MAR08027CC BY 4.0Reference data
L-lysyl-[protein]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl-[protein]+S-adenosyl-L-homocysteine+hydron
Catalysed by EEF1AKMT4 or METTL21C or SMYD4 or METTL13 or SETD6 or SETD7 or EEF1AKMT3 or SETD2 or KMT5A or PRDM9 or SMYD2 or SETD4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:51736CC BY 4.0Reference data
L-lysyl(20)-[histone H4]+S-adenosyl-L-methionineN(6)-methyl-L-lysyl(20)-[histone H4]+S-adenosyl-L-homocysteine+hydron
Catalysed by KMT5B or KMT5C or KMT5A or PRDM9 or PRDM6 or SETD4
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:60344CC BY 4.0Reference data