Proteins/UNIPROT:Q15828

CST6

ProteinUNIPROT:Q15828

High affinity inhibitor for cathepsin L, cathepsin L2 (cathepsin V), and legumain. Involved in the regulation of epidermal cornification, and hair follicle morphogenesis and maintenance..

Function from UniProtKB (Q15828), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

ectodermal dysplasia 15, hypohidrotic/hair type has a germline basis in CST6DiseaseGenCC HGNC:2478|MONDO:0032804Inferred only

Statements

21 statements

21 statements · 2 reference databases · Subject: CST6 · Sources: Hetionet, WikiPathways

Order

ACOT2 covaries with CST6ProteinHetionet hetionet:covaries:10965-1474Inferred only
CST6 covaries with FRAT1ProteinHetionet hetionet:covaries:10023-1474Inferred only
LRRC4B covaries with CST6ProteinHetionet hetionet:covaries:1474-94030Inferred only
NDRG2 covaries with CST6ProteinHetionet hetionet:covaries:1474-57447Inferred only
NTN3 covaries with CST6ProteinHetionet hetionet:covaries:1474-4917Inferred only
CST6 interacts with GSK3BProteinHetionet hetionet:interacts:1474-2932Inferred only
CST6 participates in Pancreatic cancer subtypesPathwayWikiPathways WP5390Inferred only
CST6 participates in Vitamin D receptor pathwayPathwayWikiPathways WP2877Inferred only
ALK increases the expression of CST6ProteinHetionet hetionet:regulates:238-1474Inferred only
APC increases the expression of CST6ProteinHetionet hetionet:regulates:324-1474Inferred only
ASL increases the expression of CST6ProteinHetionet hetionet:regulates:435-1474Inferred only
BLVRA increases the expression of CST6ProteinHetionet hetionet:regulates:644-1474Inferred only

Show the remaining 9

CBFA2T3 increases the expression of CST6ProteinHetionet hetionet:regulates:863-1474Inferred only
CD320 increases the expression of CST6ProteinHetionet hetionet:regulates:51293-1474Inferred only
CEMIP2 increases the expression of CST6ProteinHetionet hetionet:regulates:23670-1474Inferred only
CRADD increases the expression of CST6ProteinHetionet hetionet:regulates:8738-1474Inferred only
CTRB1 increases the expression of CST6ProteinHetionet hetionet:regulates:1504-1474Inferred only
ID2 increases the expression of CST6ProteinHetionet hetionet:regulates:3398-1474Inferred only
NCOA3 increases the expression of CST6ProteinHetionet hetionet:regulates:8202-1474Inferred only
PRKAR1A increases the expression of CST6ProteinHetionet hetionet:regulates:5573-1474Inferred only
SUZ12 increases the expression of CST6ProteinHetionet hetionet:regulates:23512-1474Inferred only

Other names

2 names

Resolves to: CST6

Also called: Cystatin-6Cystatin-E

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