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Proteins/UNIPROT:Q7L266
Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine..
Function from UniProtKB (Q7L266), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
114 statements
114 statements · 6 reference databases · Subject: ASRGL1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
3 reactions
L-asparagine+waterL-aspartate+proton+ammonium
Reaction pageLeft to rightBalancedEC 3.4.19.5mitochondrial matrix
Human-GEM MAR03862CC BY 4.0Reference data
L-asparagine+waterL-aspartate+proton+ammonium
Catalysed by
7 names
Resolves to: ASRGL1
Reaction pageLeft to rightBalancedEC 3.5.1.1, 3.5.1.38cytosol
Human-GEM MAR04172CC BY 4.0Reference data
L-asparagine+waterL-aspartate+ammonium
Reaction pageLeft to rightBalanced
Rhea RHEA:21016CC BY 4.0Reference data