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Reach

glutathione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

507 compounds within 3 steps: 52 in 1, 111 in 2, 344 in 3

Does it reach a compound?

One step

(13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
1. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O
Catalysed by GPX1, GSTA1, GPX2, GPX4
taurochenodeoxycholateReach from here →
1. taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
Catalysed by ABCC4inner side of the membrane, outer side of the membrane

Two steps

(5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione = (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
2. (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(15S)-hydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate
Catalysed by GPX1, GPX2, GPX4, ALOX5
AReach from here →
1. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
2. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O
Catalysed by PTGES, and 3 more

Page 2 of 11

MGST3

, GPX1

, GPX2

One of 3 routes

a quinoneReach from here →

a quinone + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + a quinol
a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)

Catalysed by SQOR, CYC1, UQCRFS1outer side of the membraneOne of 6 routes

prostaglandin E3Reach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of prostaglandin E3 (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

prostaglandin A2Reach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of prostaglandin A2 (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

prostaglandin B1Reach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of prostaglandin B1 (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

leukotriene F4Reach from here →

leukotriene C4 = leukotriene A4 + glutathione
leukotriene C4 hydrolysis

Catalysed by MGST3, GSTM4, LTC4S, MGST2cytosolOne of 4 routes

epsilon-(gamma-L-glutamyl)-L-lysineReach from here →

glutathione = L-cysteinylglycine + 5-oxo-L-proline
epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Catalysed by CHAC2, CHAC1, GGACT

(5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →

(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
(5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroxy-(15S)-hydroperoxy-(6E,8Z,11Z,13E)-eicosatetraenoate

Catalysed by PTGES, MGST3, GPX1, GPX2 and 3 more

N-(4-oxoglutaryl)-L-cysteinylglycineReach from here →

glutathione + H2O = L-cysteinylglycine + L-glutamate
N-(4-oxoglutaryl)-L-cysteinylglycine + H2O = L-cysteinylglycine + 2-oxoglutarate

Catalysed by GGT3P, GGT1, GGT5, GGT6 and 2 more

an organic moleculeReach from here →

a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CP, PRDX6, CYP2D7, CYP1A1 and 23 more

N-octanoyl-(2S)-hydroxyglycineReach from here →

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by CLIC1, GSTO1, GSTO2, PAM

N-decanoyl-(2S)-hydroxyglycineReach from here →

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by CLIC1, GSTO1, GSTO2, PAM

N-dodecanoyl-(2S)-hydroxyglycineReach from here →

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by CLIC1, GSTO1, GSTO2, PAM

N-tetradecanoyl-(2S)-hydroxyglycineReach from here →

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by CLIC1, GSTO1, GSTO2, PAM

N-(9Z-octadecenoyl)-(2S)-hydroxyglycineReach from here →

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by CLIC1, GSTO1, GSTO2, PAM

N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycineReach from here →

L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
N-(9Z,12Z,15Z)-octadecatrienoylglycine + 2 L-ascorbate + O2 = N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Catalysed by CLIC1, GSTO1, GSTO2, PAM

an S-substituted L-cysteinylglycineReach from here →

RX + glutathione = an S-substituted glutathione + a halide anion + H(+)
an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate

Catalysed by GSTT4, GSTA4, GSTZ1, LANCL1 and 24 more

L-cystine-bis-glycineReach from here →

glutathione + H2O = L-cysteinylglycine + L-glutamate
2 L-cysteinylglycine + [protein]-disulfide = L-cystine-bis-glycine + [protein]-dithiol

Catalysed by GGT3P, GGT1, GGT5, GGT6 and 2 more

(5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoateReach from here →

(12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O
(12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(12S)-hydroxy-(6E,8Z,10E,14Z)-eicosatetraenoate

Catalysed by GPX1, GPX4, ALOX5

acetylcholineReach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of acetylcholine (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

pyruvateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
3-mercaptopyruvate:sulfide sulfurtransferase

Catalysed by TSTD1, MPST, TSTcytosolOne of 2 routes

CHEBI:15519Reach from here →

cholate(in) + glutathione(in) + ATP + H2O = cholate(out) + glutathione(out) + ADP + phosphate + H(+)
Cholate:CoA ligase (AMP-forming)

Catalysed by ABCC4, SLC27A2, SLC27A5inner side of the membrane, outer side of the membrane, endoplasmic reticulum

(S)-malateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
transport of malate and sulfite (cytosol to mitochondria)

Catalysed by TSTD1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

15(S)-HPETEReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
Glutathione: 15-HPETE oxidoreductase

Catalysed by GSR, GPX5, GPX1, GPX2 and 6 morecytosolOne of 3 routes

CHEBI:15650Reach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of leukotriene E4 (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 1 moreextracellular space, cytosolOne of 2 routes

formateReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
S-formylglutathione + H2O = formate + glutathione + H(+)

Catalysed by ESD

(R)-lactateReach from here →

(R)-S-lactoylglutathione = methylglyoxal + glutathione
(R)-S-lactoylglutathione + H2O = (R)-lactate + glutathione + H(+)

Catalysed by GLO1, HAGH

methanethiolReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

Catalysed by TSTD1, SELENBP1

sulfateReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
sulfite:ferricytochrome-c oxidoreductase

Catalysed by TSTD1, SUOXmitochondrial matrix, cytosolOne of 6 routes

ureaReach from here →

urate(out) + glutathione(in) = urate(in) + glutathione(out)
Peroxidase

Catalysed by SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

dimethylarsinateReach from here →

methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
methylarsonous acid + S-adenosyl-L-methionine = dimethylarsinate + S-adenosyl-L-homocysteine + 2 H(+)

Catalysed by GSTO1, GSTO2, HEMK2

L-cystineReach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
cystine to cysteine conversion

Catalysed by GSRcytosol

lithocholic acidReach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of lithocholate (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

(S)-lactateReach from here →

urate(out) + glutathione(in) = urate(in) + glutathione(out)
urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)

Catalysed by SLC22A13, SLC22A12inner side of the membrane, outer side of the membrane

taurochenodeoxycholate 3-sulfateReach from here →

taurochenodeoxycholate(in) + glutathione(in) + ATP + H2O = taurochenodeoxycholate(out) + glutathione(out) + ADP + phosphate + H(+)
taurochenodeoxycholate + 3'-phosphoadenylyl sulfate = taurochenodeoxycholate 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by ABCC4, SULT2A1inner side of the membrane, outer side of the membrane

formaldehydeReach from here →

S-formylglutathione + H2O = formate + glutathione + H(+)
alcohol dehydrogenase (formaldehyde)

Catalysed by ESD, ADH1C, ADH1A, ADH5 and 3 morecytosol

CHEBI:16856Reach from here →

2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
Glutathione: 15-HPETE oxidoreductase

Catalysed by GSR, GPX5, GPX1, GPX2 and 6 morecytosolOne of 33 routes

ferrocytochrome cReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
sulfite:ferricytochrome-c oxidoreductase

Catalysed by TSTD1, SUOXmitochondrial matrix, cytosol

bilirubin IXalphaReach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of bilirubin (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

(R)-lactaldehydeReach from here →

(R)-S-lactoylglutathione = methylglyoxal + glutathione
(R)-Lactaldehyde:NAD+ oxidoreductase (glutathione-formylating)

Catalysed by GLO1, ADH1C, ADH1A, ADH4 and 4 morecytosol

taurolithocholateReach from here →

1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

Catalysed by PTGES, LANCL1, GSTM4, MGST2 and 2 moreextracellular space, cytosolOne of 2 routes

CHEBI:17208Reach from here →

urate(out) + glutathione(in) = urate(in) + glutathione(out)
ascorbate to monodehydroascorbate conversion

Catalysed by SLC22A13inner side of the membrane, outer side of the membrane, cytosol

L-cysteineReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
L-serine hydro-lyase (adding hydrogen sulfide, L-cysteine-forming)

Catalysed by TSTD1, CBScytosolOne of 4 routes

xanthineReach from here →

urate(out) + glutathione(in) = urate(in) + glutathione(out)
xanthine + NAD(+) + H2O = urate + NADH + H(+)

Catalysed by SLC22A13, XDHinner side of the membrane, outer side of the membraneOne of 2 routes

fumaric acidReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
transport of fumarate and sulfite (cytosol to mitochondria)

Catalysed by TSTD1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

5-hydroxyisourateReach from here →

urate(out) + glutathione(in) = urate(in) + glutathione(out)
urate:oxygen oxidoreductase

Catalysed by SLC22A13inner side of the membrane, outer side of the membrane, cytosol

hydrogen cyanideReach from here →

thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
thiosulfate:cyanide sulfurtranserase

Catalysed by TSTD1, MPST, TSTmitochondrial matrixOne of 2 routes