(9Z,12Z)-octadecadienoyl-CoA

Two steps

• (S)-methylmalonyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. (S)-methylmalonyl-CoA hydrolase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrix

• 3'-dephospho-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. acid phosphatase 2, lysosomal (CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, lysosomeOne of 2 routes

• (2E)-dodecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. (2E)-dodecenoyl-CoA formation

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrixOne of 3 routes

• 4,8,12-trimethyltridecanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. propanoyl-CoA C-acyltransferase (3-ketopristanoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, peroxisomeOne of 2 routes

• butanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Butanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 9 routes

• dodecanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lauric acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• glutaryl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Production of Glutaryl Carnitine

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 2 routes

• eicosanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (eicosanoate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 13 routes

• itaconyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Itaconate:CoA ligase (GDP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 2 routes

• tetradecanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (myristic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 12 routes

• phytanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. phytanate-CoA ligase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosolOne of 5 routes

• octadecanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 8 morecytosolOne of 16 routes

• (13S)-hydroperoxy-(9Z,11E)-octadecadienoateReach from here →
  1. Linoleoyl-CoA hydrolase
  2. Linoleate:oxygen 13-oxidoreductase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 2 routes

• a 1-acylglycerone 3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

  Catalysed by GNPATcytosol

• a 1,2-diacyl-sn-glycero-3-phosphocholineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by LPGAT1cytosolOne of 2 routes

• an N-acylglycineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + glycine = an N-acylglycine + CoA + H(+)

  Catalysed by GLYATL3, GLYAT, GLYATL2cytosol

• sphing-4-enineReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. acyl-CoA:sphingosine N-acyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol, Golgi apparatusOne of 2 routes

• spermidineReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. diamine N-acetyltransferase (N1-acetylspermidine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 3 routes

• L-methionineReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetylmethionine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA

  Catalysed by LCLAT1, MBOAT7cytosol

• a 1-acyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. sn-glycerol 3-phosphate + an acyl-CoA = a 1-acyl-sn-glycero-3-phosphate + CoA

  Catalysed by GPAT3, GPAT2, GPAT4, GPAMcytosol

• L-alanineReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. amino-acid N-acetyltransferase (N-acetyl-L-alanine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol, mitochondrial matrix

• L-asparagineReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-asparagine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• L,L-cystathionineReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. N-acetylglutamate synthase (N-acetyl-L-cystathionine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol, mitochondrial matrix

• a 1-acyl-sn-glycero-3-phosphocholineReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
  2. 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoate + H(+)

  Catalysed by LPCAT3, PNPLA8

• (3Z)-dodecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. acetyl-CoA C-acyltransferase (3-oxomyrist-5-enoyl-CoA)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, mitochondrial matrixOne of 3 routes

• a 1,2-diacyl-sn-glycero-3-phosphateReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA

  Catalysed by AGPAT2, GPAT3, GPAT2, LCLAT1 and 9 morecytosol

• (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate:CoA ligase (AMP-forming)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol, endoplasmic reticulumOne of 3 routes

• deoxycholoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 4 routes

• (9S)-hydroperoxy-(10E,12Z)-octadecadienoateReach from here →
  1. Linoleoyl-CoA hydrolase
  2. linoleate:oxygen 9-oxidoreductase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 1 morecytosol

• decanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. medium-chain acyl-CoA ligase (decanoic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 7 morecytosolOne of 8 routes

• (2E)-hexadecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 4 routes

• (9Z)-hexadecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (palmitolate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 12 routes

• a cardiolipinReach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + an acyl-CoA = a cardiolipin + CoA

  Catalysed by HADHAcytosol

• (2E)-octenoyl-CoAReach from here →
  1. Beta Oxidation of Fatty Acid
  2. trans-oct-2-enoyl-CoA reductase

  Catalysed by ACADM, ACADS, MECRmitochondrial matrixOne of 5 routes

• 3-hydroxyisovaleryl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. (3-Hydroxyisovalerylcoa->3-Hydroxyisovalerylcarnitine)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosol

• an all-trans-retinyl esterReach from here →
  1. acyl-CoA pool formation and breakdown
  2. all-trans-retinol + an acyl-CoA = an all-trans-retinyl ester + CoA

  Catalysed by DGAT1, PNPLA4, AWAT2, DGAT2cytosol

• CHEBI:63544Reach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (adrenic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 8 routes

• a 1-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
  2. 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + H2O = a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoate + H(+)

  Catalysed by LPCAT3, PNPLA8

• a 1,2-diacyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acyl-CoA pool formation and breakdown
  2. a 1-acyl-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by LPCAT4, LPCAT3, MBOAT1, MBOAT2cytosol

• a triacyl-sn-glycerolReach from here →
  1. acyl-CoA pool formation and breakdown
  2. an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA

  Catalysed by DGAT1, MOGAT2, AWAT2, MOGAT3 and 2 morecytosol

• a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
  1. acyl-CoA pool formation and breakdown
  2. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA

  Catalysed by LCLAT1, LPCAT1, GPAMcytosol

• hexacosanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (cerotic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 6 routes

• tetracosanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (lignocerate)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 11 routes

• docosanoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (behenic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 10 routes

• (2E)-octadecenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. Carnitine O-Palmitoyltransferase

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosolOne of 3 routes

• 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoAReach from here →
  1. fatty acyl-CoA desaturase (N-C18:2CoA -> N-C18:3CoA)
  2. (6Z,9Z,12Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z)-eicosatrienoyl-CoA + CO2 + CoA

  Catalysed by FADS1, FADS2, ELOVL7, ELOVL5cytosol

• (6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoAReach from here →
  1. (6Z,9Z)-octadecadienoyl-CoA hydrolase
  2. long-chain-fatty-acid-CoA ligase (stearidonic acid)

  Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 9 routes

• 1-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z,12Z-octadecadienoyl)-N-acetylsphing-4-enine + 1-hexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LPCAT3, MBOAT2, LPCAT1, PLA2G15One of 5 routes

• 1,2-dihexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. (9Z,12Z)-octadecadienoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA
  2. 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine

  Catalysed by LPCAT3, MBOAT2, LPCAT1, TAFAZZIN